Literature DB >> 2992943

Common features of polyomavirus mutants selected on PCC4 embryonal carcinoma cells.

F Melin, H Pinon, C Reiss, C Kress, N Montreau, D Blangy.   

Abstract

The genomic rearrangements of six polyomavirus mutants selected on PCC4 embryonal carcinoma cells have been compared and their common characteristics pointed out. All mutants show a duplication which includes at least the adenovirus type 5 (Ad5) E1A-like enhancer core sequence plus a deletion of variable size and location. The presence of the second enhancer core sequence, the SV40-like enhancer, is not required for expression of the PyEC PCC4 phenotype. Two of these mutants are also able to express polyomavirus T antigen on F9 and LT1 cells. Multiadaptation seems to require the duplication of the Ad5 E1A-like core sequence, the maintenance of the SV40-like core sequence and a local change in DNA stability.

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Year:  1985        PMID： 2992943      PMCID： PMC554420          DOI： 10.1002/j.1460-2075.1985.tb03853.x

Source DB:  PubMed          Journal:  EMBO J        ISSN： 0261-4189            Impact factor:   11.598


  33 in total

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Authors:  F Melin; H Pinon; C Kress; D Blangy
Journal:  J Virol       Date:  1985-03       Impact factor: 5.103

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Journal:  Proc Natl Acad Sci U S A       Date:  1973-12       Impact factor: 11.205
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  29 in total

1.  Biological activities of oligonucleotides spanning the F9 point mutation within the enhancer region of polyomavirus DNA.

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Journal:  J Virol       Date:  1988-03       Impact factor: 5.103

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Journal:  Microbiol Rev       Date:  1991-09

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Journal:  Mol Cell Biol       Date:  1989-09       Impact factor: 4.272

5.  Two overlapping sequence motifs within the polyomavirus enhancer are independently the targets of stimulation by both the tumor promoter 12-O-tetradecanoylphorbol-13-acetate and the Ha-ras oncogene.

Authors:  Y Yamaguchi; M Satake; Y Ito
Journal:  J Virol       Date:  1989-03       Impact factor: 5.103

6.  Replicative cis-advantage of polyomavirus regulatory region mutants in different murine cell lines.

Authors:  V De Simone; P Amati
Journal:  J Virol       Date:  1987-05       Impact factor: 5.103

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Authors:  F Hilberg; C Stocking; W Ostertag; M Grez
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9.  Differential regulation of viral and cellular genes in F9 mouse embryonal carcinoma cells.

Authors:  M J Sleigh
Journal:  Nucleic Acids Res       Date:  1987-11-25       Impact factor: 16.971

10.  A pancreas specificity results from the combination of polyomavirus and Moloney murine leukemia virus enhancer.

Authors:  R Rochford; B A Campbell; L P Villarreal
Journal:  Proc Natl Acad Sci U S A       Date:  1987-01       Impact factor: 11.205
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