Literature DB >> 3025873

A pancreas specificity results from the combination of polyomavirus and Moloney murine leukemia virus enhancer.

R Rochford, B A Campbell, L P Villarreal.   

Abstract

An infectious recombinant polyomavirus was constructed in which a regulatory region of its genome, the B enhancer region (nucleotides 5128-5265) has been replaced with the 72- or 73-base-pair repeat enhancer from the Moloney murine leukemia virus genome. We show that this recombinant polyomavirus displays a strong tissue specificity for the pancreas of mice. This organ was not permissive for either the parental polyomavirus, which is predominantly kidney and salivary gland specific, or the Moloney murine leukemia virus, which is lymphotropic. This result indicated that tissue specificity can be achieved by a combination of apparently modular elements. Some of the implications of a modular mechanism of tissue specificity are considered.

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Year:  1987        PMID： 3025873      PMCID： PMC304225          DOI： 10.1073/pnas.84.2.449

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  33 in total

1.  A new method for sequencing DNA.

Authors:  A M Maxam; W Gilbert
Journal:  Proc Natl Acad Sci U S A       Date:  1977-02       Impact factor: 11.205

2.  Polyoma virus DNA replication requires an enhancer.

Authors:  J de Villiers; W Schaffner; C Tyndall; S Lupton; R Kamen
Journal:  Nature       Date:  1984 Nov 15-21       Impact factor: 49.962

3.  Two distinct enhancers with different cell specificities coexist in the regulatory region of polyoma.

Authors:  P Herbomel; B Bourachot; M Yaniv
Journal:  Cell       Date:  1984-12       Impact factor: 41.582

4.  A region of the polyoma virus genome between the replication origin and late protein coding sequences is required in cis for both early gene expression and viral DNA replication.

Authors:  C Tyndall; G La Mantia; C M Thacker; J Favaloro; R Kamen
Journal:  Nucleic Acids Res       Date:  1981-12-11       Impact factor: 16.971

5.  The SV40 72 base repair repeat has a striking effect on gene expression both in SV40 and other chimeric recombinants.

Authors:  P Moreau; R Hen; B Wasylyk; R Everett; M P Gaub; P Chambon
Journal:  Nucleic Acids Res       Date:  1981-11-25       Impact factor: 16.971

6.  Expression of a beta-globin gene is enhanced by remote SV40 DNA sequences.

Authors:  J Banerji; S Rusconi; W Schaffner
Journal:  Cell       Date:  1981-12       Impact factor: 41.582

7.  Mutation near the polyoma DNA replication origin permits productive infection of F9 embryonal carcinoma cells.

Authors:  F K Fujimura; P L Deininger; T Friedmann; E Linney
Journal:  Cell       Date:  1981-03       Impact factor: 41.582

8.  The SV40 72 bp repeat preferentially potentiates transcription starting from proximal natural or substitute promoter elements.

Authors:  B Wasylyk; C Wasylyk; P Augereau; P Chambon
Journal:  Cell       Date:  1983-02       Impact factor: 41.582

9.  Isolation of polyomavirus mutants multiadapted to murine embryonal carcinoma cells.

Authors:  F Melin; H Pinon; C Kress; D Blangy
Journal:  J Virol       Date:  1985-03       Impact factor: 5.103

10.  Specific expression of an elastase-human growth hormone fusion gene in pancreatic acinar cells of transgenic mice.

Authors:  D M Ornitz; R D Palmiter; R E Hammer; R L Brinster; G H Swift; R J MacDonald
Journal:  Nature       Date:  1985 Feb 14-20       Impact factor: 49.962
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  21 in total

1.  Induction of lymphomas by the hamster papovavirus correlates with massive replication of nonrandomly deleted extrachromosomal viral genomes.

Authors:  S Scherneck; V Delmas; F Vogel; J Feunteun
Journal:  J Virol       Date:  1987-12       Impact factor: 5.103

2.  Functional heterogeneity of a large family of human LTR-like promoters and enhancers.

Authors:  A Feuchter; D Mager
Journal:  Nucleic Acids Res       Date:  1990-03-11       Impact factor: 16.971

Review 3.  Relationship of eukaryotic DNA replication to committed gene expression: general theory for gene control.

Authors:  L P Villarreal
Journal:  Microbiol Rev       Date:  1991-09

4.  Mapping of functional regions of murine retrovirus long terminal repeat enhancers: enhancer domains interact and are not independent in their contributions to enhancer activity.

Authors:  T Hollon; F K Yoshimura
Journal:  J Virol       Date:  1989-08       Impact factor: 5.103

5.  Systematic binding analysis of the insulin gene transcription control region: insulin and immunoglobulin enhancers utilize similar transactivators.

Authors:  L G Moss; J B Moss; W J Rutter
Journal:  Mol Cell Biol       Date:  1988-06       Impact factor: 4.272

6.  Requirements for species-specific papovavirus DNA replication.

Authors:  E R Bennett; M Naujokas; J A Hassell
Journal:  J Virol       Date:  1989-12       Impact factor: 5.103

7.  Polyomavirus DNA replication in the pancreas and in a transformed pancreas cell line has distinct enhancer requirements.

Authors:  R Rochford; L P Villarreal
Journal:  J Virol       Date:  1991-04       Impact factor: 5.103

Review 8.  The evolution of small DNA viruses of eukaryotes: past and present considerations.

Authors:  F F Shadan; L P Villarreal
Journal:  Virus Genes       Date:  1995       Impact factor: 2.332

9.  E1A represses wild-type and F9-selected polyomavirus DNA replication by a mechanism not requiring depression of large tumor antigen transcription.

Authors:  N J DePolo; L P Villarreal
Journal:  J Virol       Date:  1991-06       Impact factor: 5.103

10.  Adult mouse kidneys become permissive to acute polyomavirus infection and reactivate persistent infections in response to cellular damage and regeneration.

Authors:  I A Atencio; F F Shadan; X J Zhou; N D Vaziri; L P Villarreal
Journal:  J Virol       Date:  1993-03       Impact factor: 5.103
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