Literature DB >> 2992942

Proviral activation of the putative oncogene Pim-1 in MuLV induced T-cell lymphomas.

G Selten, H T Cuypers, A Berns.   

Abstract

Proviral integration near the Pim-1 gene is frequently observed in murine leukemia virus induced T-cell lymphomas in mice. Integration in the Pim-1 domain is associated with the presence of enhanced levels of a Pim-1 mRNA, which is normally expressed as a predominant 2.8 kb species at low levels in lymphoid tissues. The majority of integrations occurred in the 3' region of the Pim-1 transcription unit. This resulted in transcripts ranging in size from 2.0 to 2.6 kb, which were terminated in the 5' proviral LTR. Dependent on the site of integration up to 1300 bases of Pim-1 specific sequences were missing from the modified Pim-1 mRNA in these lymphomas.

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Year:  1985        PMID： 2992942      PMCID： PMC554419          DOI： 10.1002/j.1460-2075.1985.tb03852.x

Source DB:  PubMed          Journal:  EMBO J        ISSN： 0261-4189            Impact factor:   11.598


  36 in total

1.  Multiple arrangements of viral DNA and an activated host oncogene in bursal lymphomas.

Authors:  G S Payne; J M Bishop; H E Varmus
Journal:  Nature       Date:  1982-01-21       Impact factor: 49.962

2.  Mechanism of activation of a human oncogene.

Authors:  C J Tabin; S M Bradley; C I Bargmann; R A Weinberg; A G Papageorge; E M Scolnick; R Dhar; D R Lowy; E H Chang
Journal:  Nature       Date:  1982-11-11       Impact factor: 49.962

3.  Differential expression of cellular oncogenes during pre- and postnatal development of the mouse.

Authors:  R Müller; D J Slamon; J M Tremblay; M J Cline; I M Verma
Journal:  Nature       Date:  1982-10-14       Impact factor: 49.962

4.  A point mutation is responsible for the acquisition of transforming properties by the T24 human bladder carcinoma oncogene.

Authors:  E P Reddy; R K Reynolds; E Santos; M Barbacid
Journal:  Nature       Date:  1982-11-11       Impact factor: 49.962

5.  Many tumors induced by the mouse mammary tumor virus contain a provirus integrated in the same region of the host genome.

Authors:  R Nusse; H E Varmus
Journal:  Cell       Date:  1982-11       Impact factor: 41.582

6.  Analysis of the env gene of a molecularly cloned and biologically active Moloney mink cell focus-forming proviral DNA.

Authors:  R A Bosselman; F van Straaten; C Van Beveren; I M Verma; M Vogt
Journal:  J Virol       Date:  1982-10       Impact factor: 5.103

Review 7.  Translocations among antibody genes in human cancer.

Authors:  P Leder; J Battey; G Lenoir; C Moulding; W Murphy; H Potter; T Stewart; R Taub
Journal:  Science       Date:  1983-11-18       Impact factor: 47.728

8.  Activation of the cellular oncogene c-erbB by LTR insertion: molecular basis for induction of erythroblastosis by avian leukosis virus.

Authors:  Y K Fung; W G Lewis; L B Crittenden; H J Kung
Journal:  Cell       Date:  1983-06       Impact factor: 41.582

9.  Tumorigenesis by mouse mammary tumor virus: evidence for a common region for provirus integration in mammary tumors.

Authors:  G Peters; S Brookes; R Smith; C Dickson
Journal:  Cell       Date:  1983-06       Impact factor: 41.582

10.  Involvement of c-myc in MuLV-induced T cell lymphomas in mice: frequency and mechanisms of activation.

Authors:  G Selten; H T Cuypers; M Zijlstra; C Melief; A Berns
Journal:  EMBO J       Date:  1984-12-20       Impact factor: 11.598
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  83 in total

Review 1.  For better or for worse: the role of Pim oncogenes in tumorigenesis.

Authors:  Martijn C Nawijn; Andrej Alendar; Anton Berns
Journal:  Nat Rev Cancer       Date:  2010-12-09       Impact factor: 60.716

2.  p53-dependent induction of prostate cancer cell senescence by the PIM1 protein kinase.

Authors:  Marina Zemskova; Michael B Lilly; Ying-Wei Lin; Jin H Song; Andrew S Kraft
Journal:  Mol Cancer Res       Date:  2010-07-20       Impact factor: 5.852

3.  Comparative molecular genetic analysis of lymphomas from six inbred mouse strains.

Authors:  M L Mucenski; H G Bedigian; M M Shull; N G Copeland; N A Jenkins
Journal:  J Virol       Date:  1988-03       Impact factor: 5.103

4.  Characterization of the testes-specific pim-1 transcript in rat.

Authors:  D Wingett; R Reeves; N S Magnuson
Journal:  Nucleic Acids Res       Date:  1992-06-25       Impact factor: 16.971

5.  SL3-3 enhancer factor 1 transcriptional activators are required for tumor formation by SL3-3 murine leukemia virus.

Authors:  B Hallberg; J Schmidt; A Luz; F S Pedersen; T Grundström
Journal:  J Virol       Date:  1991-08       Impact factor: 5.103

6.  Tumor progression in murine leukemia virus-induced T-cell lymphomas: monitoring clonal selections with viral and cellular probes.

Authors:  H T Cuypers; G C Selten; M Zijlstra; R E de Goede; C J Melief; A J Berns
Journal:  J Virol       Date:  1986-10       Impact factor: 5.103

7.  Synthesis and evaluation of novel inhibitors of Pim-1 and Pim-2 protein kinases.

Authors:  Zuping Xia; Christian Knaak; Jian Ma; Zanna M Beharry; Campbell McInnes; Wenxue Wang; Andrew S Kraft; Charles D Smith
Journal:  J Med Chem       Date:  2009-01-08       Impact factor: 7.446

8.  Radiation leukemia virus common integration at the Kis2 locus: simultaneous overexpression of a novel noncoding RNA and of the proximal Phf6 gene.

Authors:  Séverine Landais; Renaud Quantin; Eric Rassart
Journal:  J Virol       Date:  2005-09       Impact factor: 5.103

9.  A small molecule inhibitor of Pim protein kinases blocks the growth of precursor T-cell lymphoblastic leukemia/lymphoma.

Authors:  Ying-Wei Lin; Zanna M Beharry; Elizabeth G Hill; Jin H Song; Wenxue Wang; Zuping Xia; Zhenhua Zhang; Peter D Aplan; Jon C Aster; Charles D Smith; Andrew S Kraft
Journal:  Blood       Date:  2009-11-23       Impact factor: 22.113

10.  Sequence tags of provirus integration sites in DNAs of tumors induced by the murine retrovirus SL3-3.

Authors:  A B Sørensen; M Duch; H W Amtoft; P Jørgensen; F S Pedersen
Journal:  J Virol       Date:  1996-06       Impact factor: 5.103
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