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Literature DB >> 21150935

For better or for worse: the role of Pim oncogenes in tumorigenesis.

Martijn C Nawijn¹, Andrej Alendar, Anton Berns.

Abstract

Pim oncogenes are overexpressed in a wide range of tumours from a haematological and epithelial origin. Pim genes encode serine/threonine kinases that have been shown to counteract the increased sensitivity to apoptosis induction that is associated with MYC-driven tumorigenesis. Recently, considerable progress has been made in characterizing the pathways of PIM-mediated survival signalling. Given the unique structure of their active site and the minimal phenotype of mice mutant for all Pim family members, these oncogenes might be promising targets for highly specific and selective drugs with favourable toxicity profiles. In this Review, we discuss the physiological functions and oncogenic activities of Pim kinases.

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Year: 2010 PMID： 21150935 DOI： 10.1038/nrc2986

Source DB: PubMed Journal: Nat Rev Cancer ISSN： 1474-175X Impact factor: 60.716

173 in total

1. Structure and substrate specificity of the Pim-1 kinase.

Authors: Alex N Bullock; Judit Debreczeni; Ann L Amos; Stefan Knapp; Benjamin E Turk
Journal: J Biol Chem Date: 2005-10-13 Impact factor: 5.157

2. IL-4 selectively inhibits IL-2-triggered Stat5 activation, but not proliferation, in human T cells.

Authors: A Castro; T K Sengupta; D C Ruiz; E Yang; L B Ivashkiv
Journal: J Immunol Date: 1999-02-01 Impact factor: 5.422

3. The 44 kDa Pim-1 kinase directly interacts with tyrosine kinase Etk/BMX and protects human prostate cancer cells from apoptosis induced by chemotherapeutic drugs.

Authors: Y Xie; K Xu; B Dai; Z Guo; T Jiang; H Chen; Y Qiu
Journal: Oncogene Date: 2006-01-05 Impact factor: 9.867

4. Structural basis of constitutive activity and a unique nucleotide binding mode of human Pim-1 kinase.

Authors: Kevin C Qian; Lian Wang; Eugene R Hickey; Joey Studts; Kevin Barringer; Charline Peng; Anthony Kronkaitis; Jun Li; Andre White; Sheenah Mische; Bennett Farmer
Journal: J Biol Chem Date: 2004-11-03 Impact factor: 5.157

5. Control of inducible gene expression by signal-dependent transcriptional elongation.

Authors: Diana C Hargreaves; Tiffany Horng; Ruslan Medzhitov
Journal: Cell Date: 2009-07-10 Impact factor: 41.582

6. Serine/threonine kinase Pim-2 promotes liver tumorigenesis induction through mediating survival and preventing apoptosis of liver cell.

Authors: Jianping Gong; Jinjing Wang; Ke Ren; Chang'an Liu; Bo Li; Yujun Shi
Journal: J Surg Res Date: 2008-04-22 Impact factor: 2.192

7. Growth and survival mechanisms associated with perineural invasion in prostate cancer.

Authors: Gustavo E Ayala; Hong Dai; Michael Ittmann; Rile Li; Michael Powell; Anna Frolov; Thomas M Wheeler; Timothy C Thompson; David Rowley
Journal: Cancer Res Date: 2004-09-01 Impact factor: 12.701

8. Hypoxia-mediated up-regulation of Pim-1 contributes to solid tumor formation.

Authors: Jian Chen; Masanobu Kobayashi; Stephanie Darmanin; Yi Qiao; Christopher Gully; Ruiying Zhao; Satoshi Kondo; Hua Wang; Huamin Wang; Sai-Ching Jim Yeung; Mong-Hong Lee
Journal: Am J Pathol Date: 2009-06-15 Impact factor: 4.307

9. Proviral activation of the putative oncogene Pim-1 in MuLV induced T-cell lymphomas.

Authors: G Selten; H T Cuypers; A Berns
Journal: EMBO J Date: 1985-07 Impact factor: 11.598

10. Constitutive nuclear factor kappaB activity is required for survival of activated B cell-like diffuse large B cell lymphoma cells.

Authors: R E Davis; K D Brown; U Siebenlist; L M Staudt
Journal: J Exp Med Date: 2001-12-17 Impact factor: 14.307

177 in total

1. Inhibition of Pim1 kinase activation attenuates allergen-induced airway hyperresponsiveness and inflammation.

Authors: Yoo Seob Shin; Katsuyuki Takeda; Yoshiki Shiraishi; Yi Jia; Meiqin Wang; Leila Jackson; A Dale Wright; Laura Carter; John Robinson; Erik Hicken; Erwin W Gelfand
Journal: Am J Respir Cell Mol Biol Date: 2011-11-10 Impact factor: 6.914

2. Pim1 kinase promotes angiogenesis through phosphorylation of endothelial nitric oxide synthase at Ser-633.

Authors: Ming Chen; Bing Yi; Ni Zhu; Xin Wei; Guan-Xin Zhang; Shengdong Huang; Jianxin Sun
Journal: Cardiovasc Res Date: 2015-11-23 Impact factor: 10.787

3. Pim1 kinase is upregulated in glioblastoma multiforme and mediates tumor cell survival.

Authors: Susann Herzog; Matthias Alexander Fink; Kerstin Weitmann; Claudius Friedel; Stefan Hadlich; Sönke Langner; Katharina Kindermann; Tobias Holm; Andreas Böhm; Eskil Eskilsson; Hrvoje Miletic; Markus Hildner; Michael Fritsch; Silke Vogelgesang; Christoph Havemann; Christoph Alexander Ritter; Henriette Elisabeth Meyer zu Schwabedissen; Bernhard Rauch; Wolfgang Hoffmann; Heyo Klaus Kroemer; Henry Schroeder; Sandra Bien-Möller
Journal: Neuro Oncol Date: 2014-08-25 Impact factor: 12.300

Review 4. PIM1: a promising target in patients with triple-negative breast cancer.

Authors: Wen Zhao; RuiYue Qiu; Pan Li; Jin Yang
Journal: Med Oncol Date: 2017-07-18 Impact factor: 3.064

5. Targeting Pim Kinases and DAPK3 to Control Hypertension.

Authors: David A Carlson; Miriam R Singer; Cindy Sutherland; Clara Redondo; Leila T Alexander; Philip F Hughes; Stefan Knapp; Susan B Gurley; Matthew A Sparks; Justin A MacDonald; Timothy A J Haystead
Journal: Cell Chem Biol Date: 2018-07-19 Impact factor: 8.116

Review 6. Rapamycin-resistant effector T-cell therapy.

Authors: Daniel H Fowler
Journal: Immunol Rev Date: 2014-01 Impact factor: 12.988

7. Expression of PIM-1 in salivary gland adenoid cystic carcinoma: Association with tumor progression and patients' prognosis.

Authors: Xin Zhu; Yunfang Yu; Xiuxiu Hou; Jiajie Xu; Zhuo Tan; Xilin Nie; Zhiqiang Ling; Minghua Ge
Journal: Oncol Lett Date: 2017-11-14 Impact factor: 2.967

8. RNAi screen identifies a synthetic lethal interaction between PIM1 overexpression and PLK1 inhibition.

Authors: Riet van der Meer; Ha Yong Song; Seong-Hoon Park; Sarki A Abdulkadir; Meejeon Roh
Journal: Clin Cancer Res Date: 2014-04-25 Impact factor: 12.531

9. The Pim-1 protein kinase is an important regulator of MET receptor tyrosine kinase levels and signaling.

Authors: Bo Cen; Ying Xiong; Jin H Song; Sandeep Mahajan; Rachel DuPont; Kristen McEachern; Daniel J DeAngelo; Jorge E Cortes; Mark D Minden; Allen Ebens; Alice Mims; Amanda C LaRue; Andrew S Kraft
Journal: Mol Cell Biol Date: 2014-04-28 Impact factor: 4.272

10. Elevation of receptor tyrosine kinases by small molecule AKT inhibitors in prostate cancer is mediated by Pim-1.

Authors: Bo Cen; Sandeep Mahajan; Wenxue Wang; Andrew S Kraft
Journal: Cancer Res Date: 2013-04-12 Impact factor: 12.701