Literature DB >> 29926229

The role of the mitochondrial calcium uniporter (MCU) complex in cancer.

Adina Vultur1, Christine S Gibhardt1, Hedwig Stanisz2, Ivan Bogeski3.   

Abstract

The important role of mitochondria in cancer biology is gaining momentum. With their regulation of cell survival, metabolism, basic cell building blocks, and immunity, among other functions, mitochondria affect not only cancer progression but also the response and resistance to current treatments. Calcium ions are constantly shuttled in and out of mitochondria; thus, playing an important role in the regulation of various cellular processes. The mitochondrial calcium uniporter (MCU) channel and its associated regulators transport calcium across the inner mitochondrial membrane to the mitochondrial matrix. Due to this central role and the capacity to affect cell behavior and fate, the MCU complex is being investigated in different cancers and cancer-related conditions. Here, we review current knowledge on the role of the MCU complex in multiple cancer types and models; we also provide a perspective for future research and clinical considerations.

Entities:  

Keywords:  Calcium; Cancer; MCU; MICU; Metabolism; Mitochondria; ROS; Redox

Mesh：

Substances：

Year:  2018        PMID： 29926229     DOI： 10.1007/s00424-018-2162-8

Source DB:  PubMed          Journal:  Pflugers Arch        ISSN： 0031-6768            Impact factor:   3.657


  106 in total

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Journal:  Proc Natl Acad Sci U S A       Date:  2016-03-14       Impact factor: 11.205

Review 7.  Mitochondrial ion channels/transporters as sensors and regulators of cellular redox signaling.

Authors:  Jin O-Uchi; Shin-Young Ryu; Bong Sook Jhun; Stephen Hurst; Shey-Shing Sheu
Journal:  Antioxid Redox Signal       Date:  2014-02-03       Impact factor: 8.401

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Journal:  Mol Biol Cell       Date:  2014-01-15       Impact factor: 4.138
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Review 5.  Mitochondria: Insights into Crucial Features to Overcome Cancer Chemoresistance.

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Review 10.  Membrane Transporters and Channels in Melanoma.

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