BACKGROUND: The applicability of ultra-low-dose computed tomography (CT) for attenuation correction (AC) of single-photon-emission computed tomography myocardial perfusion imaging (SPECT-MPI) remains elusive. METHODS AND RESULTS: One-hundred patients underwent one-day 99mTc-tetrofosmin stress-rest MPI and non-contrast enhanced cardiac CT with 120, 80, and 70 kilovolt peak (kVp) tube voltage and tube current of 200 milliamperes for creation of AC maps. Normalized percent myocardial uptake from SPECT-MPI using 80 kVp scans for AC showed excellent correlation vs AC from 120 kVp scans for stress [intraclass correlation (ICC) = 0.988, 95% CI = 0.986-0.989, P < .001] and rest (ICC = 0.985, 95% CI = 0.983-0.987, P < .001) with narrow Bland-Altman limits of agreement (BA-LA) (- 5.3% to 4.5% and - 5.4% to 4.4%, respectively) and minimal bias (- 0.4% and - 0.5%, respectively). Correlation of AC SPECT-MPI based on 70 vs 120 kVp scans was excellent for stress (ICC = 0.988, 95% CI = 0.986-0.989, P < .001) and rest (ICC = 0.986, 95% CI = 0.984-0.987, P < .001) with narrow BA-LA (- 5.3% to 4.4% and - 5.2% to 4.5%, respectively) and small bias (- 0.4% and - 0.3%, respectively). Mean effective radiation dose for the 120, 80 and 70 kVp scans were 0.58 ± 0.07, 0.19 ± 0.02, and 0.12 ± 0.01 mSv, respectively. CONCLUSIONS: Attenuation maps for MPI obtained from ultra-low radiation dose CT scans are interchangeable with attenuation maps from standard-dose CT while offering a substantial reduction in radiation dose exposure.
BACKGROUND: The applicability of ultra-low-dose computed tomography (CT) for attenuation correction (AC) of single-photon-emission computed tomography myocardial perfusion imaging (SPECT-MPI) remains elusive. METHODS AND RESULTS: One-hundred patients underwent one-day 99mTc-tetrofosmin stress-rest MPI and non-contrast enhanced cardiac CT with 120, 80, and 70 kilovolt peak (kVp) tube voltage and tube current of 200 milliamperes for creation of AC maps. Normalized percent myocardial uptake from SPECT-MPI using 80 kVp scans for AC showed excellent correlation vs AC from 120 kVp scans for stress [intraclass correlation (ICC) = 0.988, 95% CI = 0.986-0.989, P < .001] and rest (ICC = 0.985, 95% CI = 0.983-0.987, P < .001) with narrow Bland-Altman limits of agreement (BA-LA) (- 5.3% to 4.5% and - 5.4% to 4.4%, respectively) and minimal bias (- 0.4% and - 0.5%, respectively). Correlation of AC SPECT-MPI based on 70 vs 120 kVp scans was excellent for stress (ICC = 0.988, 95% CI = 0.986-0.989, P < .001) and rest (ICC = 0.986, 95% CI = 0.984-0.987, P < .001) with narrow BA-LA (- 5.3% to 4.4% and - 5.2% to 4.5%, respectively) and small bias (- 0.4% and - 0.3%, respectively). Mean effective radiation dose for the 120, 80 and 70 kVp scans were 0.58 ± 0.07, 0.19 ± 0.02, and 0.12 ± 0.01 mSv, respectively. CONCLUSIONS: Attenuation maps for MPI obtained from ultra-low radiation dose CT scans are interchangeable with attenuation maps from standard-dose CT while offering a substantial reduction in radiation dose exposure.
Authors: Aju P Pazhenkottil; Jelena-Rima Ghadri; Rene N Nkoulou; Mathias Wolfrum; Ronny R Buechel; Silke M Küest; Lars Husmann; Bernhard A Herzog; Oliver Gaemperli; Philipp A Kaufmann Journal: J Nucl Med Date: 2011-02 Impact factor: 10.057
Authors: Olivier F Clerc; Tobias A Fuchs; Mathias Possner; Jan Vontobel; Fran Mikulicic; Julia Stehli; Riccardo Liga; Dominik C Benz; Christoph Gräni; Aju P Pazhenkottil; Oliver Gaemperli; Ronny R Buechel; Philipp A Kaufmann Journal: Eur Heart J Cardiovasc Imaging Date: 2016-03-16 Impact factor: 6.875
Authors: Bernhard A Herzog; Ronny R Buechel; Lars Husmann; Aju P Pazhenkottil; Irene A Burger; Mathias Wolfrum; Rene N Nkoulou; Ines Valenta; Jelena R Ghadri; Valerie Treyer; Philipp A Kaufmann Journal: J Nucl Med Date: 2010-09-16 Impact factor: 10.057
Authors: Andrew J Einstein; Thomas N B Pascual; Mathew Mercuri; Ganesan Karthikeyan; João V Vitola; John J Mahmarian; Nathan Better; Salah E Bouyoucef; Henry Hee-Seung Bom; Vikram Lele; V Peter C Magboo; Erick Alexánderson; Adel H Allam; Mouaz H Al-Mallah; Albert Flotats; Scott Jerome; Philipp A Kaufmann; Osnat Luxenburg; Leslee J Shaw; S Richard Underwood; Madan M Rehani; Ravi Kashyap; Diana Paez; Maurizio Dondi Journal: Eur Heart J Date: 2015-04-21 Impact factor: 29.983