Literature DB >> 2991933

Papillomavirus genomes in human cervical tumors: analysis of their transcriptional activity.

H Lehn, P Krieg, G Sauer.   

Abstract

Four of six human cervical carcinoma biopsies were shown to contain the DNA of the human papillomavirus type 16 (HPV-16) covalently linked with the tumor cell DNA. HPV-16-specific mRNA species were observed in only one of the four tumors. No such sequences were found in the three other specimens in conditions that permitted the detection of less than one mRNA molecule per cell. It is concluded that maintenance of the malignant nature of these cervical tumors does not depend on the continuous transcriptional activity of HPV-16.

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Year:  1985        PMID： 2991933      PMCID： PMC391158          DOI： 10.1073/pnas.82.16.5540

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  37 in total

1.  High incidence area of cattle cancer with a possible interaction between an environmental carcinogen and a papilloma virus.

Authors:  W F Jarrett; P E McNeil; W T Grimshaw; I E Selman; W I McIntyre
Journal:  Nature       Date:  1978-07-20       Impact factor: 49.962

2.  Condylomatous lesions of the cervix. II. Cytologic, colposcopic and histopathologic study.

Authors:  A Meisels; R Fortin; M Roy
Journal:  Acta Cytol       Date:  1977 May-Jun       Impact factor: 2.319

Review 3.  Human papillomavirus and cancer of the uterine cervix.

Authors:  A Meisels; C Morin
Journal:  Gynecol Oncol       Date:  1981-10       Impact factor: 5.482

4.  A new papillomavirus associated with alimentary cancer in cattle.

Authors:  M Saveria Campo; M H Moar; W F Jarrett; H M Laird
Journal:  Nature       Date:  1980-07-10       Impact factor: 49.962

Review 5.  Human papillomavirus infection of the uterine cervix.

Authors:  A Meisels; C Morin; M Casas-Cordero
Journal:  Int J Gynecol Pathol       Date:  1982       Impact factor: 2.762

6.  Properties of a normal mouse cell DNA sequence (sarc) homologous to the src sequence of Moloney sarcoma virus.

Authors:  M Oskarsson; W L McClements; D G Blair; J V Maizel; G F Vande Woude
Journal:  Science       Date:  1980-03-14       Impact factor: 47.728

7.  Definition of precursors.

Authors:  Y S Fu; J W Reagan; R M Richart
Journal:  Gynecol Oncol       Date:  1981-10       Impact factor: 5.482

8.  Partial characterization of viral DNA from human genital warts (Condylomata acuminata).

Authors:  L Gissmann; H zur Hausen
Journal:  Int J Cancer       Date:  1980-05-15       Impact factor: 7.396

9.  Transcriptional organization of bovine papillomavirus type 1.

Authors:  L W Engel; C A Heilman; P M Howley
Journal:  J Virol       Date:  1983-09       Impact factor: 5.103

10.  The transforming function of bovine papillomavirus DNA.

Authors:  Y Nakabayashi; S K Chattopadhyay; D R Lowy
Journal:  Proc Natl Acad Sci U S A       Date:  1983-10       Impact factor: 11.205
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  35 in total

1.  Transcriptional differences of the human papillomavirus type 16 genome between precancerous lesions and invasive carcinomas.

Authors:  H Shirasawa; Y Tomita; K Kubota; T Kasai; S Sekiya; H Takamizawa; B Simizu
Journal:  J Virol       Date:  1988-03       Impact factor: 5.103

2.  Detection of transcripts of human papillomaviruses 16 and 18 in cancer-derived cell lines and cervical biopsies by enzyme immunoassay for DNA-RNA hybrids following solution hybridization.

Authors:  F Coutlée; K V Shah; J S Rader; J L Currie; R P Viscidi
Journal:  J Clin Microbiol       Date:  1991-05       Impact factor: 5.948

3.  Binding of high-risk human papillomavirus E6 oncoproteins to the human homologue of the Drosophila discs large tumor suppressor protein.

Authors:  T Kiyono; A Hiraiwa; M Fujita; Y Hayashi; T Akiyama; M Ishibashi
Journal:  Proc Natl Acad Sci U S A       Date:  1997-10-14       Impact factor: 11.205

4.  Hepatocellular carcinoma and hepatitis B virus infection: molecular evidence for monoclonal origin and expansion of malignantly transformed hepatocytes.

Authors:  H E Blum; W B Offensperger; E Walter; S Offensperger; A Wahl; C Zeschnigk; W Gerok
Journal:  J Cancer Res Clin Oncol       Date:  1987       Impact factor: 4.553

5.  Identification of the E5 open reading frame of human papillomavirus type 16.

Authors:  C L Halbert; D A Galloway
Journal:  J Virol       Date:  1988-03       Impact factor: 5.103

Review 6.  Viral and cellular oncogenes in papillomavirus-associated cancers.

Authors:  M S Campo
Journal:  Br J Cancer Suppl       Date:  1988-12

7.  Alteration of cell cycle kinase complexes in human papillomavirus E6- and E7-expressing fibroblasts precedes neoplastic transformation.

Authors:  Y Xiong; D Kuppuswamy; Y Li; E M Livanos; M Hixon; A White; D Beach; T D Tlsty
Journal:  J Virol       Date:  1996-02       Impact factor: 5.103

8.  Lymphoproliferative response to fusion proteins of human papillomaviruses in patients with cervical intraepithelial neoplasia.

Authors:  H A Cubie; M Norval; L Crawford; L Banks; T Crook
Journal:  Epidemiol Infect       Date:  1989-12       Impact factor: 2.451

9.  The E7 gene of human papillomavirus type 16 is sufficient for immortalization of human epithelial cells.

Authors:  C L Halbert; G W Demers; D A Galloway
Journal:  J Virol       Date:  1991-01       Impact factor: 5.103

10.  Analysis of the physical state of different human papillomavirus DNAs in intraepithelial and invasive cervical neoplasm.

Authors:  A P Cullen; R Reid; M Campion; A T Lörincz
Journal:  J Virol       Date:  1991-02       Impact factor: 5.103
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