Literature DB >> 1845902

The E7 gene of human papillomavirus type 16 is sufficient for immortalization of human epithelial cells.

C L Halbert1, G W Demers, D A Galloway.   

Abstract

The contribution of the E6 and E7 open reading frames of human papillomavirus type 6b (HPV6b) and HPV16 to immortalization of human keratinocytes was evaluated by using amphotropic recombinant retroviruses. The HPV16 E7 gene could immortalize primary human keratinocytes without the cooperation of the viral E6 gene; however, E6 was able to contribute significantly to the efficiency of the E7 immortalizing function. Infection of HFE cells with retroviruses carrying the 16E6, 6bE6, or 6bE6E7 open reading frame did not result in immortalization.

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Year:  1991        PMID： 1845902      PMCID： PMC240541     

Source DB:  PubMed          Journal:  J Virol        ISSN： 0022-538X            Impact factor:   5.103


  43 in total

1.  The E6 and E7 genes of the human papillomavirus type 16 together are necessary and sufficient for transformation of primary human keratinocytes.

Authors:  K Münger; W C Phelps; V Bubb; P M Howley; R Schlegel
Journal:  J Virol       Date:  1989-10       Impact factor: 5.103

2.  Immortalization of human foreskin keratinocytes by various human papillomavirus DNAs corresponds to their association with cervical carcinoma.

Authors:  C D Woodworth; J Doniger; J A DiPaolo
Journal:  J Virol       Date:  1989-01       Impact factor: 5.103

3.  Structure and transcription of human papillomavirus sequences in cervical carcinoma cells.

Authors:  E Schwarz; U K Freese; L Gissmann; W Mayer; B Roggenbuck; A Stremlau; H zur Hausen
Journal:  Nature       Date:  1985 Mar 7-13       Impact factor: 49.962

4.  The human papilloma virus-16 E7 oncoprotein is able to bind to the retinoblastoma gene product.

Authors:  N Dyson; P M Howley; K Münger; E Harlow
Journal:  Science       Date:  1989-02-17       Impact factor: 47.728

5.  Papillomavirus genomes in human cervical tumors: analysis of their transcriptional activity.

Authors:  H Lehn; P Krieg; G Sauer
Journal:  Proc Natl Acad Sci U S A       Date:  1985-08       Impact factor: 11.205

6.  Presence and expression of human papillomavirus sequences in human cervical carcinoma cell lines.

Authors:  C Yee; I Krishnan-Hewlett; C C Baker; R Schlegel; P M Howley
Journal:  Am J Pathol       Date:  1985-06       Impact factor: 4.307

7.  Human papillomavirus type 16 DNA sequence.

Authors:  K Seedorf; G Krämmer; M Dürst; S Suhai; W G Röwekamp
Journal:  Virology       Date:  1985-08       Impact factor: 3.616

8.  The physical state of human papillomavirus type 16 DNA in benign and malignant genital tumours.

Authors:  M Dürst; A Kleinheinz; M Hotz; L Gissmann
Journal:  J Gen Virol       Date:  1985-07       Impact factor: 3.891

9.  Identification of the HPV-16 E6 protein from transformed mouse cells and human cervical carcinoma cell lines.

Authors:  E J Androphy; N L Hubbert; J T Schiller; D R Lowy
Journal:  EMBO J       Date:  1987-04       Impact factor: 11.598

10.  Comparison of the in vitro transforming activities of human papillomavirus types.

Authors:  A Storey; D Pim; A Murray; K Osborn; L Banks; L Crawford
Journal:  EMBO J       Date:  1988-06       Impact factor: 11.598
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  207 in total

1.  Immortalization of primary human keratinocytes by the helix-loop-helix protein, Id-1.

Authors:  R M Alani; J Hasskarl; M Grace; M C Hernandez; M A Israel; K Münger
Journal:  Proc Natl Acad Sci U S A       Date:  1999-08-17       Impact factor: 11.205

2.  Papillomavirus type 16 oncogenes downregulate expression of interferon-responsive genes and upregulate proliferation-associated and NF-kappaB-responsive genes in cervical keratinocytes.

Authors:  M Nees; J M Geoghegan; T Hyman; S Frank; L Miller; C D Woodworth
Journal:  J Virol       Date:  2001-05       Impact factor: 5.103

3.  The G(2) checkpoint is maintained by redundant pathways.

Authors:  T M Passalaris; J A Benanti; L Gewin; T Kiyono; D A Galloway
Journal:  Mol Cell Biol       Date:  1999-09       Impact factor: 4.272

4.  Isolation, immortalization, and initial characterization of uterine cell lines: an in vitro model system for the porcine uterus.

Authors:  G Wang; G A Johnson; T E Spencer; F W Bazer
Journal:  In Vitro Cell Dev Biol Anim       Date:  2000 Nov-Dec       Impact factor: 2.416

5.  PIG3V, an immortalized human vitiligo melanocyte cell line, expresses dilated endoplasmic reticulum.

Authors:  I C Le Poole; R E Boissy; R Sarangarajan; J Chen; J J Forristal; P Sheth; W Westerhof; G Babcock; P K Das; C B Saelinger
Journal:  In Vitro Cell Dev Biol Anim       Date:  2000-05       Impact factor: 2.416

6.  Destabilization of the retinoblastoma tumor suppressor by human papillomavirus type 16 E7 is not sufficient to overcome cell cycle arrest in human keratinocytes.

Authors:  A M Helt; D A Galloway
Journal:  J Virol       Date:  2001-08       Impact factor: 5.103

7.  Telomerase activation by human papillomavirus type 16 E6 protein: induction of human telomerase reverse transcriptase expression through Myc and GC-rich Sp1 binding sites.

Authors:  S T Oh; S Kyo; L A Laimins
Journal:  J Virol       Date:  2001-06       Impact factor: 5.103

8.  Both conserved region 1 (CR1) and CR2 of the human papillomavirus type 16 E7 oncogene are required for induction of epidermal hyperplasia and tumor formation in transgenic mice.

Authors:  G A Gulliver; R L Herber; A Liem; P F Lambert
Journal:  J Virol       Date:  1997-08       Impact factor: 5.103

9.  Tissue specificity of a human mitochondrial disease: differentiation-enhanced mis-splicing of the Fe-S scaffold gene ISCU renders patient cells more sensitive to oxidative stress in ISCU myopathy.

Authors:  Daniel R Crooks; Suh Young Jeong; Wing-Hang Tong; Manik C Ghosh; Hayden Olivierre; Ronald G Haller; Tracey A Rouault
Journal:  J Biol Chem       Date:  2012-10-03       Impact factor: 5.157

10.  Inactivation of both the retinoblastoma tumor suppressor and p21 by the human papillomavirus type 16 E7 oncoprotein is necessary to inhibit cell cycle arrest in human epithelial cells.

Authors:  Anna-Marija Helt; Jens Oliver Funk; Denise A Galloway
Journal:  J Virol       Date:  2002-10       Impact factor: 5.103
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