Literature DB >> 2991903

Removal of a 67-base-pair sequence in the noncoding region of protooncogene fos converts it to a transforming gene.

F Meijlink, T Curran, A D Miller, I M Verma.   

Abstract

Transformation of fibroblasts by protooncogene fos (c-fos) requires the linkage of viral long terminal repeat (LTR) sequences and interruption of 3'-noncoding sequences. We have identified an A + T-rich stretch of 67 nucleotides, located 627-693 base pairs downstream from the coding domain and 123-189 base pairs upstream from the putative poly(A) addition site, removal of which confers transforming activity to the c-fos gene. A novel regulation of the expression of the c-fos gene is proposed, which may be functional in vivo to prevent the gene from becoming an oncogene.

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Year:  1985        PMID： 2991903      PMCID： PMC390483          DOI： 10.1073/pnas.82.15.4987

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  25 in total

1.  Identification of a 39,000-dalton protein in cells transformed by the FBJ murine osteosarcoma virus.

Authors:  T Curran; N M Teich
Journal:  Virology       Date:  1982-01-15       Impact factor: 3.616

Review 2.  Cellular oncogenes and retroviruses.

Authors:  J M Bishop
Journal:  Annu Rev Biochem       Date:  1983       Impact factor: 23.643

3.  Differential expression of cellular oncogenes during pre- and postnatal development of the mouse.

Authors:  R Müller; D J Slamon; J M Tremblay; M J Cline; I M Verma
Journal:  Nature       Date:  1982-10-14       Impact factor: 49.962

4.  Cell-specific regulation of the c-myc gene by lymphocyte mitogens and platelet-derived growth factor.

Authors:  K Kelly; B H Cochran; C D Stiles; P Leder
Journal:  Cell       Date:  1983-12       Impact factor: 41.582

5.  Complete nucleotide sequence of a human c-onc gene: deduced amino acid sequence of the human c-fos protein.

Authors:  F van Straaten; R Müller; T Curran; C Van Beveren; I M Verma
Journal:  Proc Natl Acad Sci U S A       Date:  1983-06       Impact factor: 11.205

6.  FBJ murine osteosarcoma virus: identification and molecular cloning of biologically active proviral DNA.

Authors:  T Curran; G Peters; C Van Beveren; N M Teich; I M Verma
Journal:  J Virol       Date:  1982-11       Impact factor: 5.103

7.  Virus induction of osteosarcomas in mice.

Authors:  M P Finkel; B O Biskis; P B Jinkins
Journal:  Science       Date:  1966-02-11       Impact factor: 47.728

8.  Rapid induction of the expression of proto-oncogene fos during human monocytic differentiation.

Authors:  R L Mitchell; L Zokas; R D Schreiber; I M Verma
Journal:  Cell       Date:  1985-01       Impact factor: 41.582

9.  Analysis of FBJ-MuSV provirus and c-fos (mouse) gene reveals that viral and cellular fos gene products have different carboxy termini.

Authors:  C Van Beveren; F van Straaten; T Curran; R Müller; I M Verma
Journal:  Cell       Date:  1983-04       Impact factor: 41.582

10.  Expression of c-onc genes: c-fos transcripts accumulate to high levels during development of mouse placenta, yolk sac and amnion.

Authors:  R Müller; I M Verma; E D Adamson
Journal:  EMBO J       Date:  1983       Impact factor: 11.598
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  71 in total

1.  Comparative analysis of the plant mRNA-destabilizing element, DST, in mammalian and tobacco cells.

Authors:  M Feldbrügge; P Arizti; M L Sullivan; P D Zamore; J G Belasco; P J Green
Journal:  Plant Mol Biol       Date:  2002-05       Impact factor: 4.076

Review 2.  MRNA stability and the control of gene expression: implications for human disease.

Authors:  Elysia M Hollams; Keith M Giles; Andrew M Thomson; Peter J Leedman
Journal:  Neurochem Res       Date:  2002-10       Impact factor: 3.996

3.  Activity of a type 1 picornavirus internal ribosomal entry site is determined by sequences within the 3' nontranslated region.

Authors:  Elena Dobrikova; Paola Florez; Shelton Bradrick; Matthias Gromeier
Journal:  Proc Natl Acad Sci U S A       Date:  2003-11-26       Impact factor: 11.205

4.  Genome-wide analysis of mRNA decay in resting and activated primary human T lymphocytes.

Authors:  Arvind Raghavan; Rachel L Ogilvie; Cavan Reilly; Michelle L Abelson; Shalini Raghavan; Jayprakash Vasdewani; Mitchell Krathwohl; Paul R Bohjanen
Journal:  Nucleic Acids Res       Date:  2002-12-15       Impact factor: 16.971

5.  5' untranslated sequences modulate rapid mRNA degradation mediated by 3' AU-rich element in v-/c-fos recombinants.

Authors:  N Roy; G Laflamme; V Raymond
Journal:  Nucleic Acids Res       Date:  1992-11-11       Impact factor: 16.971

6.  An avian transforming retrovirus isolated from a nephroblastoma that carries the fos gene as the oncogene.

Authors:  M Nishizawa; N Goto; S Kawai
Journal:  J Virol       Date:  1987-12       Impact factor: 5.103

7.  Constitutive expression of a gene encoding a polypeptide homologous to biologically active human platelet protein in Rous sarcoma virus-transformed fibroblasts.

Authors:  P A Bedard; D Alcorta; D L Simmons; K C Luk; R L Erikson
Journal:  Proc Natl Acad Sci U S A       Date:  1987-10       Impact factor: 11.205

8.  Biochemical characterization of a virus-induced osteosarcoma-like osseous lesion in vitro.

Authors:  J Schmidt; E I Closs; E Livne; V Erfle; M Silbermann
Journal:  Calcif Tissue Int       Date:  1989-10       Impact factor: 4.333

9.  AUUUA is not sufficient to promote poly(A) shortening and degradation of an mRNA: the functional sequence within AU-rich elements may be UUAUUUA(U/A)(U/A).

Authors:  C A Lagnado; C Y Brown; G J Goodall
Journal:  Mol Cell Biol       Date:  1994-12       Impact factor: 4.272

10.  Antisense rescue defines specialized and generalized functional domains for c-Fos protein.

Authors:  J T Holt
Journal:  Mol Cell Biol       Date:  1993-06       Impact factor: 4.272
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