Literature DB >> 29914947

External Evaluation of a Gentamicin Infant Population Pharmacokinetic Model Using Data from a National Electronic Health Record Database.

Shufan Ge1, Ryan J Beechinor1, Christoph P Hornik2,3, Joseph F Standing4, Kanecia Zimmerman2,3, Michael Cohen-Wolkowiez2,3, Matthew M Laughon5, Reese Clark6, Daniel Gonzalez7.   

Abstract

Gentamicin is a common antibiotic used in neonates and infants. A recently published population pharmacokinetic (PK) model was developed using data from multiple studies, and the objective of our analyses was to evaluate the feasibility of using a national electronic health record (EHR) database for further external evaluation of this model. Our results suggest that, with proper data capture procedures, EHR data can serve as a potential data source for external evaluation of PK models.
Copyright © 2018 American Society for Microbiology.

Entities:  

Keywords:  EHR; external evaluation; gentamicin; infant; pediatrics; pharmacokinetics

Mesh：

Substances：

Year:  2018        PMID： 29914947      PMCID： PMC6125537          DOI： 10.1128/AAC.00669-18

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.938


  15 in total

1.  Xpose--an S-PLUS based population pharmacokinetic/pharmacodynamic model building aid for NONMEM.

Authors:  E N Jonsson; M O Karlsson
Journal:  Comput Methods Programs Biomed       Date:  1999-01       Impact factor: 5.428

Review 2.  Newborns and gentamicin--how much and how often?

Authors:  B Chattopadhyay
Journal:  J Antimicrob Chemother       Date:  2002-01       Impact factor: 5.790

3.  Population pharmacokinetic study of gentamicin in a large cohort of premature and term neonates.

Authors:  Aline Fuchs; Monia Guidi; Eric Giannoni; Dominique Werner; Thierry Buclin; Nicolas Widmer; Chantal Csajka
Journal:  Br J Clin Pharmacol       Date:  2014-11       Impact factor: 4.335

4.  Population pharmacokinetics of gentamicin in premature newborns.

Authors:  Benito García; Emilia Barcia; Fernando Pérez; Irene T Molina
Journal:  J Antimicrob Chemother       Date:  2006-06-16       Impact factor: 5.790

5.  A multicenter evaluation of gentamicin therapy in the neonatal intensive care unit.

Authors:  M L Glover; C L Shaffer; C M Rubino; C Cuthrell; S Schoening; E Cole; D Potter; J L Ransom; P Gal
Journal:  Pharmacotherapy       Date:  2001-01       Impact factor: 4.705

6.  Population pharmacokinetics of gentamicin and dosing optimization for infants.

Authors:  Susanna E Medellín-Garibay; Aída Rueda-Naharro; Silvia Peña-Cabia; Benito García; Silvia Romano-Moreno; Emilia Barcia
Journal:  Antimicrob Agents Chemother       Date:  2014-11-10       Impact factor: 5.191

7.  The kinetic profile of gentamicin in premature neonates.

Authors:  M J Rocha; A M Almeida; E Afonso; V Martins; J Santos; F Leitão; A C Falcão
Journal:  J Pharm Pharmacol       Date:  2000-09       Impact factor: 3.765

Review 8.  Therapeutic drug monitoring of aminoglycosides in neonates.

Authors:  Daniël J Touw; Elsbeth M Westerman; Arwen J Sprij
Journal:  Clin Pharmacokinet       Date:  2009       Impact factor: 6.447

9.  Development and Evaluation of a Gentamicin Pharmacokinetic Model That Facilitates Opportunistic Gentamicin Therapeutic Drug Monitoring in Neonates and Infants.

Authors:  Eva Germovsek; Alison Kent; Tuuli Metsvaht; Irja Lutsar; Nigel Klein; Mark A Turner; Mike Sharland; Elisabet I Nielsen; Paul T Heath; Joseph F Standing
Journal:  Antimicrob Agents Chemother       Date:  2016-07-22       Impact factor: 5.191

10.  Use of Population Pharmacokinetics and Electronic Health Records to Assess Piperacillin-Tazobactam Safety in Infants.

Authors:  Sara Salerno; Christoph P Hornik; Michael Cohen-Wolkowiez; P Brian Smith; Lawrence C Ku; Matthew S Kelly; Reese Clark; Daniel Gonzalez
Journal:  Pediatr Infect Dis J       Date:  2017-09       Impact factor: 3.806
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  4 in total

1.  Can Population Pharmacokinetics of Antibiotics be Extrapolated? Implications of External Evaluations.

Authors:  Yu Cheng; Chen-Yu Wang; Zi-Ran Li; Yan Pan; Mao-Bai Liu; Zheng Jiao
Journal:  Clin Pharmacokinet       Date:  2021-01       Impact factor: 6.447

2.  Creation of a Multicenter Pediatric Inpatient Data Repository Derived from Electronic Health Records.

Authors:  Christoph P Hornik; Andrew M Atz; Catherine Bendel; Francis Chan; Kevin Downes; Robert Grundmeier; Ben Fogel; Debbie Gipson; Matthew Laughon; Michael Miller; Michael Smith; Chad Livingston; Cindy Kluchar; Anne Heath; Chanda Jarrett; Brian McKerlie; Hetalkumar Patel; Christina Hunter
Journal:  Appl Clin Inform       Date:  2019-05-08       Impact factor: 2.342

3.  A Pharmacoepidemiologic Study of the Safety and Effectiveness of Clindamycin in Infants.

Authors:  Rachel G Greenberg; Huali Wu; Anil Maharaj; Michael Cohen-Wolkowiez; Kay M Tomashek; Blaire L Osborn; Reese H Clark; Emmanuel B Walter
Journal:  Pediatr Infect Dis J       Date:  2020-03       Impact factor: 3.806

4.  Irbesartan Attenuates Gentamicin-induced Nephrotoxicity in Rats through Modulation of Oxidative Stress and Endogenous Antioxidant Capacity.

Authors:  Hayder M Al-Kuraishy; Ali I Al-Gareeb; Marwa S Al-Nami
Journal:  Int J Prev Med       Date:  2020-02-17
  4 in total

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