Christoph P Hornik1, Andrew M Atz2, Catherine Bendel3, Francis Chan4, Kevin Downes5, Robert Grundmeier5, Ben Fogel6, Debbie Gipson7, Matthew Laughon8, Michael Miller9, Michael Smith10,11, Chad Livingston1, Cindy Kluchar1, Anne Heath1, Chanda Jarrett1, Brian McKerlie1, Hetalkumar Patel1, Christina Hunter1. 1. Duke Clinical Research Institute, Duke University School of Medicine, Durham, North Carolina, United States. 2. Department of Pediatrics, Medical University of South Carolina, Charleston, South Carolina, United States. 3. Department of Pediatrics, University of Minnesota Medical School, Minneapolis, Minnesota, United States. 4. Department of Pediatrics, Loma Linda University School of Medicine, Loma Linda, California, United States. 5. Department of Pediatrics, Perelman School of Medicine of the University of Pennsylvania, Philadelphia, Pennsylvania, United States. 6. Department of Pediatrics, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, United States. 7. Department of Pediatrics and Communicable Disease, University of Michigan, Ann Arbor, Michigan, United States. 8. Department of Pediatrics, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States. 9. Department of Pediatrics, Ann & Robert H. Lurie Children's Hospital of Chicago, Chicago, Illinois, United States. 10. Department of Pediatrics, University of Louisville School of Medicine, Louisville, Kentucky, United States. 11. Division of Pediatric Infectious Diseases, Duke University School of Medicine, Durham North Carolina, United States.
Abstract
BACKGROUND: Integration of electronic health records (EHRs) data across sites and access to that data remain limited. OBJECTIVE: We developed an EHR-based pediatric inpatient repository using nine U.S. centers from the National Institute of Child Health and Human Development Pediatric Trials Network. METHODS: A data model encompassing 147 mandatory and 99 optional elements was developed to provide an EHR data extract of all inpatient encounters from patients <17 years of age discharged between January 6, 2013 and June 30, 2017. Sites received instructions on extractions, transformation, testing, and transmission to the coordinating center. RESULTS: We generated 177 staging reports to process all nine sites' 147 mandatory and 99 optional data elements to the repository. Based on 520 prespecified criteria, all sites achieved 0% errors and <2% warnings. The repository includes 386,159 inpatient encounters from 264,709 children to support study design and conduct of future trials in children. CONCLUSION: Our EHR-based data repository of pediatric inpatient encounters utilized a customized data model heavily influenced by the PCORnet format, site-based data mapping, a comprehensive set of data testing rules, and an iterative process of data submission. The common data model, site-based extraction, and technical expertise were key to our success. Data from this repository will be used in support of Pediatric Trials Network studies and the labeling of drugs and devices for children. Georg Thieme Verlag KG Stuttgart · New York.
BACKGROUND: Integration of electronic health records (EHRs) data across sites and access to that data remain limited. OBJECTIVE: We developed an EHR-based pediatric inpatient repository using nine U.S. centers from the National Institute of Child Health and Human Development Pediatric Trials Network. METHODS: A data model encompassing 147 mandatory and 99 optional elements was developed to provide an EHR data extract of all inpatient encounters from patients <17 years of age discharged between January 6, 2013 and June 30, 2017. Sites received instructions on extractions, transformation, testing, and transmission to the coordinating center. RESULTS: We generated 177 staging reports to process all nine sites' 147 mandatory and 99 optional data elements to the repository. Based on 520 prespecified criteria, all sites achieved 0% errors and <2% warnings. The repository includes 386,159 inpatient encounters from 264,709 children to support study design and conduct of future trials in children. CONCLUSION: Our EHR-based data repository of pediatric inpatient encounters utilized a customized data model heavily influenced by the PCORnet format, site-based data mapping, a comprehensive set of data testing rules, and an iterative process of data submission. The common data model, site-based extraction, and technical expertise were key to our success. Data from this repository will be used in support of Pediatric Trials Network studies and the labeling of drugs and devices for children. Georg Thieme Verlag KG Stuttgart · New York.
Authors: Alexander G Fiks; Robert W Grundmeier; Jennifer Steffes; William G Adams; David C Kaelber; Wilson D Pace; Richard C Wasserman Journal: Pediatrics Date: 2015-06-22 Impact factor: 7.124
Authors: Andrea Trembath; Christoph P Hornik; Reese Clark; P Brian Smith; Julie Daniels; Matthew Laughon Journal: J Pediatr Date: 2013-06-12 Impact factor: 4.406
Authors: Kanecia O Zimmerman; Christoph P Hornik; Lawrence Ku; Kevin Watt; Matthew M Laughon; Margarita Bidegain; Reese H Clark; P Brian Smith Journal: J Pediatr Date: 2015-05-23 Impact factor: 6.314
Authors: Jessica E Ericson; Martyn Gostelow; Julie Autmizguine; Christoph P Hornik; Reese H Clark; Daniel K Benjamin; P Brian Smith Journal: Pediatr Infect Dis J Date: 2017-04 Impact factor: 3.806
Authors: Jacqueline G Gerhart; Fernando O Carreño; Andrea N Edginton; Jaydeep Sinha; Eliana M Perrin; Karan R Kumar; Aruna Rikhi; Christoph P Hornik; Vincent Harris; Samit Ganguly; Michael Cohen-Wolkowiez; Daniel Gonzalez Journal: Clin Pharmacokinet Date: 2021-10-07 Impact factor: 5.577
Authors: Jacqueline G Gerhart; Fernando O Carreño; Matthew Shane Loop; Craig R Lee; Andrea N Edginton; Jaydeep Sinha; Karan R Kumar; Carl M Kirkpatrick; Christoph P Hornik; Daniel Gonzalez Journal: Clin Pharmacol Ther Date: 2022-05-18 Impact factor: 6.903
Authors: Svetlana Ostapenko; Melissa Schmatz; Lakshmi Srinivasan; Okan U Elci; Scott L Weiss; Aaron J Masino; Marissa Tremoglie; Mary Catherine Harris; Robert W Grundmeier Journal: Data Brief Date: 2019-11-11
Authors: Kellie M Walters; Anna Jojic; Emily R Pfaff; Marie Rape; Donald C Spencer; Nicholas J Shaheen; Brent Lamm; Timothy S Carey Journal: J Am Med Inform Assoc Date: 2022-03-15 Impact factor: 4.497
Authors: Sarah Jane Commander; Daniel Gonzalez; Karan R Kumar; Tracy Spears; Michael Cohen-Wolkowiez; Kanecia O Zimmerman; Stephen J Balevic; Christoph P Hornik Journal: Cardiol Young Date: 2021-08-05 Impact factor: 1.023