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Literature DB >> 29910081

The Role of Xist in X-Chromosome Dosage Compensation.

Anna Sahakyan¹, Yihao Yang¹, Kathrin Plath².

Abstract

In each somatic cell of a female mammal one X chromosome is transcriptionally silenced via X-chromosome inactivation (XCI), initiating early in development. Although XCI events are conserved in mouse and human postimplantation development, regulation of X-chromosome dosage in preimplantation development occurs differently. In preimplantation development, mouse embryos undergo imprinted form of XCI, yet humans lack imprinted XCI and instead regulate gene expression of both X chromosomes by dampening transcription. The long non-coding RNA Xist/XIST is expressed in mouse and human preimplantation and postimplantation development to orchestrate XCI, but its role in dampening is unclear. In this review, we discuss recent advances in our understanding of the role of Xist in X chromosome dosage compensation in mouse and human.

Entities: CellLine Chemical Disease Gene Species

Keywords: X inactivation; Xist; dosage compensation; embryonic stem cells; lncRNAs

Mesh：

Substances：

Year: 2018 PMID： 29910081 PMCID： PMC6249047 DOI： 10.1016/j.tcb.2018.05.005

Source DB: PubMed Journal: Trends Cell Biol ISSN： 0962-8924 Impact factor: 20.808

93 in total

1. Chromosomal silencing and localization are mediated by different domains of Xist RNA.

Authors: Anton Wutz; Theodore P Rasmussen; Rudolf Jaenisch
Journal: Nat Genet Date: 2002-01-07 Impact factor: 38.330

2. Reactivation of the paternal X chromosome in early mouse embryos.

Authors: Winifred Mak; Tatyana B Nesterova; Mariana de Napoles; Ruth Appanah; Shinya Yamanaka; Arie P Otte; Neil Brockdorff
Journal: Science Date: 2004-01-30 Impact factor: 47.728

3. Jpx RNA activates Xist by evicting CTCF.

Authors: Sha Sun; Brian C Del Rosario; Attila Szanto; Yuya Ogawa; Yesu Jeon; Jeannie T Lee
Journal: Cell Date: 2013-06-20 Impact factor: 41.582

4. The Ftx Noncoding Locus Controls X Chromosome Inactivation Independently of Its RNA Products.

Authors: Giulia Furlan; Nancy Gutierrez Hernandez; Christophe Huret; Rafael Galupa; Joke Gerarda van Bemmel; Antonio Romito; Edith Heard; Céline Morey; Claire Rougeulle
Journal: Mol Cell Date: 2018-05-03 Impact factor: 17.970

5. Generalized lacZ expression with the ROSA26 Cre reporter strain.

Authors: P Soriano
Journal: Nat Genet Date: 1999-01 Impact factor: 38.330

6. A long noncoding RNA maintains active chromatin to coordinate homeotic gene expression.

Authors: Kevin C Wang; Yul W Yang; Bo Liu; Amartya Sanyal; Ryan Corces-Zimmerman; Yong Chen; Bryan R Lajoie; Angeline Protacio; Ryan A Flynn; Rajnish A Gupta; Joanna Wysocka; Ming Lei; Job Dekker; Jill A Helms; Howard Y Chang
Journal: Nature Date: 2011-03-20 Impact factor: 49.962

7. Impact of Xist RNA on chromatin modifications and transcriptional silencing maintenance at different stages of imprinted X chromosome inactivation in vole Microtus levis.

Authors: Alexander I Shevchenko; Elena V Grigor'eva; Sergey P Medvedev; Irina S Zakharova; Elena V Dementyeva; Eugeny A Elisaphenko; Anastasia A Malakhova; Sophia V Pavlova; Suren M Zakian
Journal: Chromosoma Date: 2017-11-18 Impact factor: 4.316

8. Erosion of dosage compensation impacts human iPSC disease modeling.

Authors: Shila Mekhoubad; Christoph Bock; A Sophie de Boer; Evangelos Kiskinis; Alexander Meissner; Kevin Eggan
Journal: Cell Stem Cell Date: 2012-05-04 Impact factor: 24.633

9. Human Embryonic Stem Cells Do Not Change Their X Inactivation Status during Differentiation.

Authors: Sanjeet Patel; Giancarlo Bonora; Anna Sahakyan; Rachel Kim; Constantinos Chronis; Justin Langerman; Sorel Fitz-Gibbon; Liudmilla Rubbi; Rhys J P Skelton; Reza Ardehali; Matteo Pellegrini; William E Lowry; Amander T Clark; Kathrin Plath
Journal: Cell Rep Date: 2016-12-16 Impact factor: 9.995

10. A Pooled shRNA Screen Identifies Rbm15, Spen, and Wtap as Factors Required for Xist RNA-Mediated Silencing.

Authors: Benoit Moindrot; Andrea Cerase; Heather Coker; Osamu Masui; Anne Grijzenhout; Greta Pintacuda; Lothar Schermelleh; Tatyana B Nesterova; Neil Brockdorff
Journal: Cell Rep Date: 2015-07-16 Impact factor: 9.423

46 in total

1. No imprinted XIST expression in pigs: biallelic XIST expression in early embryos and random X inactivation in placentas.

Authors: Huiying Zou; Dawei Yu; Xuguang Du; Jing Wang; Lei Chen; Yangyang Wang; Huitao Xu; Yunxuan Zhao; Shanjiang Zhao; Yunwei Pang; Yan Liu; Haisheng Hao; Xueming Zhao; Weihua Du; Yunping Dai; Ning Li; Sen Wu; Huabin Zhu
Journal: Cell Mol Life Sci Date: 2019-05-28 Impact factor: 9.261

Review 2. lncRedibly versatile: biochemical and biological functions of long noncoding RNAs.

Authors: Emily J Shields; Ana F Petracovici; Roberto Bonasio
Journal: Biochem J Date: 2019-04-10 Impact factor: 3.857

Review 3. Multimodal Long Noncoding RNA Interaction Networks: Control Panels for Cell Fate Specification.

Authors: Keriayn N Smith; Sarah C Miller; Gabriele Varani; J Mauro Calabrese; Terry Magnuson
Journal: Genetics Date: 2019-12 Impact factor: 4.562

4. Classification of Long Noncoding RNAs by k-mer Content.

Authors: Jessime M Kirk; Daniel Sprague; J Mauro Calabrese
Journal: Methods Mol Biol Date: 2021

Review 5. The long non-coding road to endogenous cardiac regeneration.

Authors: Abdel Rahman Yousry Afify
Journal: Heart Fail Rev Date: 2019-07 Impact factor: 4.214

6. Genome-Wide Analysis of the FOXA1 Transcriptional Network Identifies Novel Protein-Coding and Long Noncoding RNA Targets in Colorectal Cancer Cells.

Authors: Sarah B Lazar; Lorinc Pongor; Xiao Ling Li; Ioannis Grammatikakis; Bruna R Muys; Emily A Dangelmaier; Christophe E Redon; Sang-Min Jang; Robert L Walker; Wei Tang; Stefan Ambs; Curtis C Harris; Paul S Meltzer; Mirit I Aladjem; Ashish Lal
Journal: Mol Cell Biol Date: 2020-10-13 Impact factor: 4.272

Review 10. Probing RNA structure in vivo.

Authors: David Mitchell; Sarah M Assmann; Philip C Bevilacqua
Journal: Curr Opin Struct Biol Date: 2019-09-13 Impact factor: 6.809