Literature DB >> 29889312

DNA adducts: Formation, biological effects, and new biospecimens for mass spectrometric measurements in humans.

Byeong Hwa Yun1, Jingshu Guo1, Medjda Bellamri1, Robert J Turesky1.   

Abstract

Hazardous chemicals in the environment and diet or their electrophilic metabolites can form adducts with genomic DNA, which can lead to mutations and the initiation of cancer. In addition, reactive intermediates can be generated in the body through oxidative stress and damage the genome. The identification and measurement of DNA adducts are required for understanding exposure and the causal role of a genotoxic chemical in cancer risk. Over the past three decades, 32 P-postlabeling, immunoassays, gas chromatography/mass spectrometry, and liquid chromatography/mass spectrometry (LC/MS) methods have been established to assess exposures to chemicals through measurements of DNA adducts. It is now possible to measure some DNA adducts in human biopsy samples, by LC/MS, with as little as several milligrams of tissue. In this review article, we highlight the formation and biological effects of DNA adducts, and highlight our advances in human biomonitoring by mass spectrometric analysis of formalin-fixed paraffin-embedded tissues, untapped biospecimens for carcinogen DNA adduct biomarker research.
© 2018 Wiley Periodicals, Inc.

Entities:  

Keywords:  DNA adduct; biomarker; biomonitoring; carcinogen; mass spectrometry

Mesh：

Substances：

Year:  2018        PMID： 29889312      PMCID： PMC6289887          DOI： 10.1002/mas.21570

Source DB:  PubMed          Journal:  Mass Spectrom Rev        ISSN： 0277-7037            Impact factor:   10.946


  272 in total

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9.  Immunohistochemical demonstration of carcinogen-DNA adducts in tissues of rats given 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP): detection in paraffin-embedded sections and tissue distribution.

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10.  Detection and Discrimination of DNA Adducts Differing in Size, Regiochemistry, and Functional Group by Nanopore Sequencing.

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