Kaibao Sun1,2, Jianfei Cui3,4, Bo Wang1, Tao Jiang5, Zhongwei Chen1, Fei Cong1,2, Yan Zhuo1, Shuli Liang6,7, Rong Xue8,9, Xinguang Yu4, Lin Chen1,2. 1. State Key Laboratory of Brain and Cognitive Science, Beijing MRI Center for Brain Research, Institute of Biophysics, Chinese Academy of Sciences, 15 Datun Road, Chaoyang District, Beijing, 100101, China. 2. University of Chinese Academy of Sciences, Beijing, 100049, China. 3. Neurosurgery Department, First Affiliated Hospital of PLA General Hospital, Beijing, 100853, China. 4. Neurosurgery Department, PLA General Hospital, Beijing, 100048, China. 5. Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, 100050, China. 6. Neurosurgery Department, First Affiliated Hospital of PLA General Hospital, Beijing, 100853, China. liangsl_304@sina.com. 7. Neurosurgery Department, PLA General Hospital, Beijing, 100048, China. liangsl_304@sina.com. 8. State Key Laboratory of Brain and Cognitive Science, Beijing MRI Center for Brain Research, Institute of Biophysics, Chinese Academy of Sciences, 15 Datun Road, Chaoyang District, Beijing, 100101, China. rxue@bcslab.ibp.ac.cn. 9. University of Chinese Academy of Sciences, Beijing, 100049, China. rxue@bcslab.ibp.ac.cn.
Abstract
PURPOSE: This study was conducted to determine the benefit of magnetic resonance imaging (MRI) at 7 T in detecting structural lesions and previously unidentified abnormalities in patients with tuberous sclerosis complex (TSC). METHODS: Thirteen patients with TSC (8-36 years, seven males) previously diagnosed by 3 T MRI underwent additional imaging at 7 T, which included T1-weighted magnetization-prepared rapid gradient-echo (MPRAGE), T2-weighted turbo spin echo (TSE), SPACE fluid attenuated inversion recovery (FLAIR), susceptibility weighted imaging (SWI), white matter suppressed (WM-suppressed), and gray-white matter tissue border enhancement (GW-TBE) MPRAGE sequences. Subtle lesions, tuberal morphology, and perituberal cortex abnormalities were examined and compared to those observed at 3 T MRI using standard sequences. RESULTS: Improved visualization of TSC lesions was achieved in all subjects at 7 T compared to 3 T imaging, and three subjects received resective surgery. The 7 T T1- and T2-weighted images had high spatial resolution and provided a clear delineation of the perituberal cortex. SWI revealed abnormal blood vessel morphology. WM-suppressed and GW-TBE protocols, adjusted specifically for TSC imaging, aided in visualizing lesions and uncovered more extensive subtle lesions and abnormalities beyond the conventionally detected tubers. CONCLUSIONS: Due to its high spatial resolution and powerful new imaging protocols, 7 T MRI provided a better evaluation of subtle lesions and perituberal details compared with conventional MRI at 3 T, with potential implications for diagnosis and operative treatment of TSC and its related epilepsy.
PURPOSE: This study was conducted to determine the benefit of magnetic resonance imaging (MRI) at 7 T in detecting structural lesions and previously unidentified abnormalities in patients with tuberous sclerosis complex (TSC). METHODS: Thirteen patients with TSC (8-36 years, seven males) previously diagnosed by 3 T MRI underwent additional imaging at 7 T, which included T1-weighted magnetization-prepared rapid gradient-echo (MPRAGE), T2-weighted turbo spin echo (TSE), SPACE fluid attenuated inversion recovery (FLAIR), susceptibility weighted imaging (SWI), white matter suppressed (WM-suppressed), and gray-white matter tissue border enhancement (GW-TBE) MPRAGE sequences. Subtle lesions, tuberal morphology, and perituberal cortex abnormalities were examined and compared to those observed at 3 T MRI using standard sequences. RESULTS: Improved visualization of TSC lesions was achieved in all subjects at 7 T compared to 3 T imaging, and three subjects received resective surgery. The 7 T T1- and T2-weighted images had high spatial resolution and provided a clear delineation of the perituberal cortex. SWI revealed abnormal blood vessel morphology. WM-suppressed and GW-TBE protocols, adjusted specifically for TSC imaging, aided in visualizing lesions and uncovered more extensive subtle lesions and abnormalities beyond the conventionally detected tubers. CONCLUSIONS: Due to its high spatial resolution and powerful new imaging protocols, 7 T MRI provided a better evaluation of subtle lesions and perituberal details compared with conventional MRI at 3 T, with potential implications for diagnosis and operative treatment of TSC and its related epilepsy.
Authors: Mauro Costagli; Douglas A C Kelley; Mark R Symms; Laura Biagi; Riccardo Stara; Eleonora Maggioni; Gianluigi Tiberi; Carmen Barba; Renzo Guerrini; Mirco Cosottini; Michela Tosetti Journal: Neuroradiology Date: 2014-04-25 Impact factor: 2.804
Authors: Thomas R Henry; Marie Chupin; Stéphane Lehéricy; John P Strupp; Michael A Sikora; Zhiyi Y Sha; Kâmil Ugurbil; Pierre-François Van de Moortele Journal: Radiology Date: 2011-07-11 Impact factor: 11.105
Authors: Alberto J R Leal; Ana I Dias; José P Vieira; Ana Moreira; Luís Távora; Eulália Calado Journal: Clin Neurophysiol Date: 2008-02-21 Impact factor: 3.708
Authors: K Ridler; E T Bullmore; P J De Vries; J Suckling; G J Barker; S J Meara; S C Williams; P F Bolton Journal: Psychol Med Date: 2001-11 Impact factor: 7.723
Authors: Giske Opheim; Anja van der Kolk; Karin Markenroth Bloch; Albert J Colon; Kathryn A Davis; Thomas R Henry; Jacobus F A Jansen; Stephen E Jones; Jullie W Pan; Karl Rössler; Joel M Stein; Maria C Strandberg; Siegfried Trattnig; Pierre-Francois Van de Moortele; Maria Isabel Vargas; Irene Wang; Fabrice Bartolomei; Neda Bernasconi; Andrea Bernasconi; Boris Bernhardt; Isabella Björkman-Burtscher; Mirco Cosottini; Sandhitsu R Das; Lucie Hertz-Pannier; Sara Inati; Michael T Jurkiewicz; Ali R Khan; Shuli Liang; Ruoyun Emily Ma; Srinivasan Mukundan; Heath Pardoe; Lars H Pinborg; Jonathan R Polimeni; Jean-Philippe Ranjeva; Esther Steijvers; Steven Stufflebeam; Tim J Veersema; Alexandre Vignaud; Natalie Voets; Serge Vulliemoz; Christopher J Wiggins; Rong Xue; Renzo Guerrini; Maxime Guye Journal: Neurology Date: 2020-12-22 Impact factor: 9.910