Literature DB >> 2986145

Predicted protein sequence of the murine I-E-beta S-polypeptide chain from cDNA and genomic clones.

L Mengle-Gaw, H O McDevitt.   

Abstract

Ia antigens are polymorphic cell-surface glycoprotein complexes, encoded within the I region of the mouse major histocompatibility complex, that control the ability of the organism to mount effective antigen-specific immune responses. We have isolated and determined the nucleotide sequences of cDNA and genomic clones for the I-E beta s gene and we present the predicted protein sequence for most of the E beta s polypeptide chain. The E beta s polypeptide shows 95% protein homology to the other cloned E beta alleles. Comparison of the protein sequences of five E beta alleles from haplotypes that differ in responder phenotype to pigeon cytochrome c suggests that the structure of one of the E beta hypervariable regions may determine responsiveness to this antigen.

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Year:  1985        PMID： 2986145      PMCID： PMC397676          DOI： 10.1073/pnas.82.9.2910

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  33 in total

1.  Organization of the immune response genes.

Authors:  J W Uhr; J D Capra; E S Vitetta; R G Cook
Journal:  Science       Date:  1979-10-19       Impact factor: 47.728

2.  Detection of specific sequences among DNA fragments separated by gel electrophoresis.

Authors:  E M Southern
Journal:  J Mol Biol       Date:  1975-11-05       Impact factor: 5.469

Review 3.  MHC-restricted cytotoxic T cells: studies on the biological role of polymorphic major transplantation antigens determining T-cell restriction-specificity, function, and responsiveness.

Authors:  R M Zinkernagel; P C Doherty
Journal:  Adv Immunol       Date:  1979       Impact factor: 3.543

Review 4.  Empirical predictions of protein conformation.

Authors:  P Y Chou; G D Fasman
Journal:  Annu Rev Biochem       Date:  1978       Impact factor: 23.643

5.  Screening lambdagt recombinant clones by hybridization to single plaques in situ.

Authors:  W D Benton; R W Davis
Journal:  Science       Date:  1977-04-08       Impact factor: 47.728

6.  Lambdoid phages that simplify the recovery of in vitro recombinants.

Authors:  N E Murray; W J Brammar; K Murray
Journal:  Mol Gen Genet       Date:  1977-01-07

7.  Isolation of high-molecular-weight DNA from mammalian cells.

Authors:  M Gross-Bellard; P Oudet; P Chambon
Journal:  Eur J Biochem       Date:  1973-07-02

Review 8.  Determinant selection and macrophage function in genetic control of the immune response.

Authors:  A S Rosenthal
Journal:  Immunol Rev       Date:  1978       Impact factor: 12.988

9.  Two-gene control of the expression of a murine Ia antigen.

Authors:  P P Jones; D B Murphy; H O McDevitt
Journal:  J Exp Med       Date:  1978-10-01       Impact factor: 14.307

10.  Analysis of H-2 and Ia molecules by two-dimensional gel electrophoresis.

Authors:  P P Jones
Journal:  J Exp Med       Date:  1977-11-01       Impact factor: 14.307
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  12 in total

1.  Evolution of major histocompatibility complex class II allelic diversity: direct descent in mice and humans.

Authors:  A S Lundberg; H O McDevitt
Journal:  Proc Natl Acad Sci U S A       Date:  1992-07-15       Impact factor: 11.205

2.  Nonobese diabetic and nonobese nondiabetic mice have unique MHC class II haplotypes.

Authors:  H Acha-Orbea; L Scarpellino
Journal:  Immunogenetics       Date:  1991       Impact factor: 2.846

Review 3.  Evolution of class II genes: role of selection in both the maintenance of polymorphism and the retention of non-expressed alleles.

Authors:  P P Jones; A B Begovich; F M Tacchini-Cottier; T H Vu
Journal:  Immunol Res       Date:  1990       Impact factor: 2.829

4.  Recombination hot spots within the I region of the mouse H-2 complex map to the E beta and E alpha genes.

Authors:  W P Lafuse; C S David
Journal:  Immunogenetics       Date:  1986       Impact factor: 2.846

5.  Sequence analysis and structure-function correlations of murine q, k, u, s, and f haplotype I-A beta cDNA clones.

Authors:  P Estess; A B Begovich; M Koo; P P Jones; H O McDevitt
Journal:  Proc Natl Acad Sci U S A       Date:  1986-06       Impact factor: 11.205

6.  Anti-L3T4 antibody inhibits the lysis of H-2 class II antigen-negative target cells by L3T4+ cytotoxic T lymphocytes.

Authors:  S Macphail; O Stutman
Journal:  Proc Natl Acad Sci U S A       Date:  1988-07       Impact factor: 11.205

7.  A gene in the H-2S:H-2D interval of the major histocompatibility complex which is transcribed in B cells and macrophages.

Authors:  I Tsuge; F W Shen; M Steinmetz; E A Boyse
Journal:  Immunogenetics       Date:  1987       Impact factor: 2.846

8.  Structure and polymorphism of horse MHC class II DRB genes: convergent evolution in the antigen binding site.

Authors:  K Gustafsson; L Andersson
Journal:  Immunogenetics       Date:  1994       Impact factor: 2.846

9.  The paradox of MHC-DRB exon/intron evolution: alpha-helix and beta-sheet encoding regions diverge while hypervariable intronic simple repeats coevolve with beta-sheet codons.

Authors:  F W Schwaiger; E Weyers; C Epplen; J Brün; G Ruff; A Crawford; J T Epplen
Journal:  J Mol Evol       Date:  1993-09       Impact factor: 2.395

10.  Organization of a functional chicken class II B gene.

Authors:  R Zoorob; G Béhar; G Kroemer; C Auffray
Journal:  Immunogenetics       Date:  1990       Impact factor: 2.846
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