Hoi Lun Cheng1,2, Amanda Sainsbury3, Frances Garden4,5, Myuran Sritharan1,2, Karen Paxton6, Georgina Luscombe7, Catherine Hawke7, Katharine Steinbeck1,2. 1. The Children's Hospital at Westmead, Academic Department of Adolescent Medicine, Westmead, New South Wales, Australia. 2. The University of Sydney, Faculty of Medicine and Health, Sydney Medical School, Discipline of Child and Adolescent Health, Westmead, New South Wales, Australia. 3. The University of Sydney, Faculty of Medicine and Health, The Boden Institute of Obesity, Nutrition, Exercise, and Eating Disorders, Charles Perkins Centre, Camperdown, New South Wales, Australia. 4. University of New South Wales, South Western Sydney Clinical School, Liverpool, New South Wales, Australia. 5. Ingham Institute for Applied Medical Research, Liverpool, New South Wales, Australia. 6. The University of Sydney, Faculty of Medicine and Health, School of Rural Health, Dubbo, New South Wales, Australia. 7. The University of Sydney, Faculty of Medicine and Health, School of Rural Health, Orange, New South Wales, Australia.
Abstract
Context: Pubertal adolescents show strong appetites. How this is mediated is unclear, but ghrelin and peptide YY (PYY) play potentially important roles. Objective: To measure ghrelin and PYY change in relation to pubertal growth. Design: Three-year prospective cohort study. Setting: Australian regional community. Participants: Eighty healthy adolescents (26 girls; 54 boys) recruited at 10 to 13 years. Main Outcome Measures: Fasting circulating total ghrelin, total PYY, IGF-1, insulin, leptin (via radioimmunoassay), estradiol and testosterone (via mass spectrometry), anthropometry, and body composition (via bioelectrical impedance). Results: Adolescents exhibited normal developmental change. Mixed models revealed positive associations for ghrelin to age2 (both sexes: P < 0.05), indicating a U-shaped trend over time. Ghrelin was also inversely associated with IGF-1 (both sexes: P < 0.05), leptin in girls (P < 0.01), and insulin in boys (P < 0.05) and negatively correlated with annual height and weight velocity (both sexes: P ≤ 0.01). PYY showed no age-related change in either sex. Neither ghrelin nor PYY were associated with Tanner stage. Weight subgroup analyses showed significant ghrelin associations with age2 in healthy-weight but not overweight and obese adolescents (7 girls; 18 boys). Conclusions: Adolescents showed a U-shaped change in ghrelin corresponding to physical and biochemical markers of growth, and no change in PYY. The overweight and obesity subgroup exhibited an apparent loss of the U-shaped ghrelin trend, but this finding may be attributed to greater maturity and its clinical significance is unclear. Further research on weight-related ghrelin and PYY trends at puberty is needed to understand how these peptides influence growth and long-term metabolic risk.
Context: Pubertal adolescents show strong appetites. How this is mediated is unclear, but ghrelin and peptide YY (PYY) play potentially important roles. Objective: To measure ghrelin and PYY change in relation to pubertal growth. Design: Three-year prospective cohort study. Setting: Australian regional community. Participants: Eighty healthy adolescents (26 girls; 54 boys) recruited at 10 to 13 years. Main Outcome Measures: Fasting circulating total ghrelin, total PYY, IGF-1, insulin, leptin (via radioimmunoassay), estradiol and testosterone (via mass spectrometry), anthropometry, and body composition (via bioelectrical impedance). Results: Adolescents exhibited normal developmental change. Mixed models revealed positive associations for ghrelin to age2 (both sexes: P < 0.05), indicating a U-shaped trend over time. Ghrelin was also inversely associated with IGF-1 (both sexes: P < 0.05), leptin in girls (P < 0.01), and insulin in boys (P < 0.05) and negatively correlated with annual height and weight velocity (both sexes: P ≤ 0.01). PYY showed no age-related change in either sex. Neither ghrelin nor PYY were associated with Tanner stage. Weight subgroup analyses showed significant ghrelin associations with age2 in healthy-weight but not overweight and obese adolescents (7 girls; 18 boys). Conclusions: Adolescents showed a U-shaped change in ghrelin corresponding to physical and biochemical markers of growth, and no change in PYY. The overweight and obesity subgroup exhibited an apparent loss of the U-shaped ghrelin trend, but this finding may be attributed to greater maturity and its clinical significance is unclear. Further research on weight-related ghrelin and PYY trends at puberty is needed to understand how these peptides influence growth and long-term metabolic risk.
Authors: Christopher Mancuso; Alyssa Izquierdo; Meghan Slattery; Kendra R Becker; Franziska Plessow; Jennifer J Thomas; Kamryn T Eddy; Elizabeth A Lawson; Madhusmita Misra Journal: Psychoneuroendocrinology Date: 2019-12-23 Impact factor: 4.905
Authors: N Almasi; H Y Zengin; N Koç; S A Uçakturk; D İskender Mazman; N Heidarzadeh Rad; M Fisunoglu Journal: J Endocrinol Invest Date: 2022-06-28 Impact factor: 5.467