N Almasi1, H Y Zengin2, N Koç3, S A Uçakturk3, D İskender Mazman4, N Heidarzadeh Rad1, M Fisunoglu5. 1. Department of Nutrition and Dietetics, Hacettepe University Faculty of Health Sciences, Ankara, Turkey. 2. Department of Biostatistics, Hacettepe University Faculty of Health Sciences, Ankara, Turkey. 3. Department of Child Endocrinology, Ministry of Health Ankara City Hospital, Ankara, Turkey. 4. Department of Child Pediatric, Ministry of Health Ankara City Hospital, Ankara, Turkey. 5. Department of Nutrition and Dietetics, Hacettepe University Faculty of Health Sciences, Ankara, Turkey. fisunogl@hacettepe.edu.tr.
Abstract
PURPOSE: Reducing the mean age of puberty onset in recent years has crucial public health, clinical, and social implications. This study aimed to evaluate the serum levels of appetite-related peptides (leptin, ghrelin, nesfatin-1, and orexin-A) and anthropometric data in girls with premature thelarche (PT). METHODS: We enrolled 44 girls aged 4-8 years diagnosed with PT and 33 age-matched healthy girls as controls. The demographic data of the girls were obtained using a questionnaire. Anthropometric data were measured and fasting blood samples were collected. RESULTS: Body weight, height, body mass index (BMI), body fat mass, and basal metabolic rate (BMR) were higher in the PT group than in the control group (p < 0.05). Serum leptin (p < 0.001), nesfatin-1 (p = 0.001), and orxein-A (p < 0.001) levels were significantly higher in the PT group than in healthy controls. However, there were no significant differences in the serum ghrelin levels between the groups (p > 0.05). The results of multivariate logistic regression revealed that serum leptin level (OR (95% CI): 42.0 (10.91, 173.06), p < 0.001), orexin-A (OR (95% CI): 1.14 (1.04, 1.24), p = 0.006), and BMI for age z-score (OR (95% CI): 6.97 (1.47, 33.4), p = 0.014) elevated the risk of incidence of PT at 4-8 girls. CONCLUSION: These results suggest that in addition to serum leptin levels, serum orexin-A and nesaftin-1 can take part in the initiation of PT. Few studies have investigated the relationship between nesfatin-1 and orexin-A levels and age at onset of puberty; hence, it should be a subject for future studies.
PURPOSE: Reducing the mean age of puberty onset in recent years has crucial public health, clinical, and social implications. This study aimed to evaluate the serum levels of appetite-related peptides (leptin, ghrelin, nesfatin-1, and orexin-A) and anthropometric data in girls with premature thelarche (PT). METHODS: We enrolled 44 girls aged 4-8 years diagnosed with PT and 33 age-matched healthy girls as controls. The demographic data of the girls were obtained using a questionnaire. Anthropometric data were measured and fasting blood samples were collected. RESULTS: Body weight, height, body mass index (BMI), body fat mass, and basal metabolic rate (BMR) were higher in the PT group than in the control group (p < 0.05). Serum leptin (p < 0.001), nesfatin-1 (p = 0.001), and orxein-A (p < 0.001) levels were significantly higher in the PT group than in healthy controls. However, there were no significant differences in the serum ghrelin levels between the groups (p > 0.05). The results of multivariate logistic regression revealed that serum leptin level (OR (95% CI): 42.0 (10.91, 173.06), p < 0.001), orexin-A (OR (95% CI): 1.14 (1.04, 1.24), p = 0.006), and BMI for age z-score (OR (95% CI): 6.97 (1.47, 33.4), p = 0.014) elevated the risk of incidence of PT at 4-8 girls. CONCLUSION: These results suggest that in addition to serum leptin levels, serum orexin-A and nesaftin-1 can take part in the initiation of PT. Few studies have investigated the relationship between nesfatin-1 and orexin-A levels and age at onset of puberty; hence, it should be a subject for future studies.
Authors: S Bellone; A Rapa; D Vivenza; N Castellino; A Petri; J Bellone; E Me; F Broglio; F Prodam; E Ghigo; G Bona Journal: J Endocrinol Invest Date: 2002-05 Impact factor: 4.256
Authors: W F Blum; P Englaro; S Hanitsch; A Juul; N T Hertel; J Müller; N E Skakkebaek; M L Heiman; M Birkett; A M Attanasio; W Kiess; W Rascher Journal: J Clin Endocrinol Metab Date: 1997-09 Impact factor: 5.958
Authors: Frank M Biro; Louise C Greenspan; Maida P Galvez; Susan M Pinney; Susan Teitelbaum; Gayle C Windham; Julianna Deardorff; Robert L Herrick; Paul A Succop; Robert A Hiatt; Lawrence H Kushi; Mary S Wolff Journal: Pediatrics Date: 2013-11-04 Impact factor: 7.124