| Literature DB >> 29852980 |
David J A Jenkins1, J David Spence2, Edward L Giovannucci3, Young-In Kim4, Robert Josse5, Reinhold Vieth6, Sonia Blanco Mejia7, Effie Viguiliouk7, Stephanie Nishi8, Sandhya Sahye-Pudaruth8, Melanie Paquette8, Darshna Patel8, Sandy Mitchell8, Meaghan Kavanagh8, Tom Tsirakis9, Lina Bachiri10, Atherai Maran9, Narmada Umatheva9, Taylor McKay9, Gelaine Trinidad9, Daniel Bernstein9, Awad Chowdhury9, Julieta Correa-Betanzo9, Gabriella Del Principe9, Anisa Hajizadeh9, Rohit Jayaraman9, Amy Jenkins9, Wendy Jenkins9, Ruben Kalaichandran9, Geithayini Kirupaharan9, Preveena Manisekaran9, Tina Qutta9, Ramsha Shahid9, Alexis Silver9, Cleo Villegas9, Jessica White9, Cyril W C Kendall11, Sathish C Pichika12, John L Sievenpiper13.
Abstract
The authors identified individual randomized controlled trials from previous meta-analyses and additional searches, and then performed meta-analyses on cardiovascular disease outcomes and all-cause mortality. The authors assessed publications from 2012, both before and including the U.S. Preventive Service Task Force review. Their systematic reviews and meta-analyses showed generally moderate- or low-quality evidence for preventive benefits (folic acid for total cardiovascular disease, folic acid and B-vitamins for stroke), no effect (multivitamins, vitamins C, D, β-carotene, calcium, and selenium), or increased risk (antioxidant mixtures and niacin [with a statin] for all-cause mortality). Conclusive evidence for the benefit of any supplement across all dietary backgrounds (including deficiency and sufficiency) was not demonstrated; therefore, any benefits seen must be balanced against possible risks.Entities:
Keywords: all-cause mortality; meta-analysis; supplements
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Year: 2018 PMID： 29852980 DOI： 10.1016/j.jacc.2018.04.020
Source DB: PubMed Journal: J Am Coll Cardiol ISSN： 0735-1097 Impact factor: 24.094