Jung Wook Huh1, Seong Hyeon Yun2, Seok Hyung Kim3, Yoon Ah Park1, Yong Beom Cho1, Hee Cheol Kim1, Woo Yong Lee1, Hee Chul Park4, Doo Ho Choi4, Joon Oh Park5, Young Suk Park5, Ho-Kyung Chun6. 1. Department of Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, 81 Irwon-ro, Gangnam-gu, Seoul, 06351, South Korea. 2. Department of Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, 81 Irwon-ro, Gangnam-gu, Seoul, 06351, South Korea. shyunmd@gmail.com. 3. Department of Pathology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea. 4. Department of Radiation Oncology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea. 5. Hematology-Oncology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea. 6. Department of Surgery, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, South Korea.
Abstract
BACKGROUND: The prognostic role of post-chemoradiotherapy (CRT) carcinoembryonic antigen (CEA) level is not clear. We evaluated the prognostic significance of post-CRT CEA level in patients with rectal cancer after preoperative CRT. METHODS: We reviewed 659 consecutive patients who underwent preoperative CRT and total mesorectal excision for non-metastatic rectal cancer. Patients were categorized into two groups according to post-CRT serum CEA level: low CEA (< 5 ng/mL) and high CEA (≥ 5 ng/mL). RESULTS: Median post-CRT CEA level was 1.7 ng/mL (range, 0.1-207.0). A high post-CRT level was significantly associated with ypStage, ypT category, tumor regression grade, and pre-CRT CEA level. The 5-year overall survival rate of the 659 patients was 87.8% with a median follow-up period of 57.0 months (range, 1.4-176.4). When the post-CRT CEA groups were divided into groups according to pre-CRT CEA level, the 5-year overall survival rates were significantly different (P < 0.001 and P = 0.001, respectively). Post-CRT CEA level was an independent prognostic factor for overall survival. Multivariate analysis revealed that operation method, differentiation, perineural invasion, postoperative chemotherapy, tumor regression grade, and post-CRT CEA level were independent prognostic factors for overall survival. CONCLUSION: The level of serum CEA after preoperative CRT was an independent prognostic factor for overall survival in patients with rectal cancer.
BACKGROUND: The prognostic role of post-chemoradiotherapy (CRT) carcinoembryonic antigen (CEA) level is not clear. We evaluated the prognostic significance of post-CRT CEA level in patients with rectal cancer after preoperative CRT. METHODS: We reviewed 659 consecutive patients who underwent preoperative CRT and total mesorectal excision for non-metastatic rectal cancer. Patients were categorized into two groups according to post-CRT serum CEA level: low CEA (< 5 ng/mL) and high CEA (≥ 5 ng/mL). RESULTS: Median post-CRT CEA level was 1.7 ng/mL (range, 0.1-207.0). A high post-CRT level was significantly associated with ypStage, ypT category, tumor regression grade, and pre-CRT CEA level. The 5-year overall survival rate of the 659 patients was 87.8% with a median follow-up period of 57.0 months (range, 1.4-176.4). When the post-CRT CEA groups were divided into groups according to pre-CRT CEA level, the 5-year overall survival rates were significantly different (P < 0.001 and P = 0.001, respectively). Post-CRT CEA level was an independent prognostic factor for overall survival. Multivariate analysis revealed that operation method, differentiation, perineural invasion, postoperative chemotherapy, tumor regression grade, and post-CRT CEA level were independent prognostic factors for overall survival. CONCLUSION: The level of serum CEA after preoperative CRT was an independent prognostic factor for overall survival in patients with rectal cancer.
Entities:
Keywords:
Carcinoembryonic antigen; Preoperative chemoradiotherapy; Prognosis; Rectal cancer
Authors: Chan Wook Kim; Chang Sik Yu; Song-Soo Yang; Kyung Ho Kim; Yong Sik Yoon; Sang Nam Yoon; Seok-Byung Lim; Jin Cheon Kim Journal: Ann Surg Oncol Date: 2011-05-03 Impact factor: 5.344
Authors: Won Kyung Cho; Doo Ho Choi; Hee Chul Park; Won Park; Jeong Il Yu; Young Suk Park; Joon Oh Park; Ho Yeong Lim; Won Ki Kang; Hee Cheol Kim; Yong Beom Cho; Seong Hyeon Yun; Woo Yong Lee Journal: Oncotarget Date: 2017-11-18