BACKGROUND: We evaluated the prognostic value of the preoperative serum carcinoembryonic antigen (CEA) level in patients with colorectal cancer (CRC). PATIENTS AND METHODS: The study group comprised 638 patients. The optimal cutoff value for the preoperative serum CEA level was determined. Predictive factors of recurrence were evaluated using multivariate analyses. The relapse-free time was investigated according to the CEA level. RESULTS: All patients underwent potentially curative resection for CRC without distant metastasis, classified as stage I, II, or III. The optimal cutoff value for preoperative serum CEA level was 10 ng/ml. Elevated preoperative serum CEA level was observed in 92 patients. Multivariate analysis identified tumor-node-metastasis (TNM) stage and preoperative serum CEA level as independent predictive factors of recurrence. The relapse-free survival between CEA levels >10 ng/ml and <10 ng/ml significantly differed in patients with stage II and III. However, there was no significant difference in relapse-free survival between CEA levels >10 ng/ml and <10 ng/ml in patients with stage I. CONCLUSION: Preoperative serum CEA is a reliable predictive factor of recurrence after curative surgery in CRC patients and a useful indicator of the optimal treatment after resection, particularly for cases classified as stage II or stage III.
BACKGROUND: We evaluated the prognostic value of the preoperative serum carcinoembryonic antigen (CEA) level in patients with colorectal cancer (CRC). PATIENTS AND METHODS: The study group comprised 638 patients. The optimal cutoff value for the preoperative serum CEA level was determined. Predictive factors of recurrence were evaluated using multivariate analyses. The relapse-free time was investigated according to the CEA level. RESULTS: All patients underwent potentially curative resection for CRC without distant metastasis, classified as stage I, II, or III. The optimal cutoff value for preoperative serum CEA level was 10 ng/ml. Elevated preoperative serum CEA level was observed in 92 patients. Multivariate analysis identified tumor-node-metastasis (TNM) stage and preoperative serum CEA level as independent predictive factors of recurrence. The relapse-free survival between CEA levels >10 ng/ml and <10 ng/ml significantly differed in patients with stage II and III. However, there was no significant difference in relapse-free survival between CEA levels >10 ng/ml and <10 ng/ml in patients with stage I. CONCLUSION: Preoperative serum CEA is a reliable predictive factor of recurrence after curative surgery in CRC patients and a useful indicator of the optimal treatment after resection, particularly for cases classified as stage II or stage III.
Authors: Soo Young Lee; Jeong Seon Jo; Hun Jin Kim; Chang Hyun Kim; Jae-Kyun Ju; Young Jin Kim; Hyeong Rok Kim Journal: Int J Colorectal Dis Date: 2014-11-01 Impact factor: 2.571
Authors: R Santiago-Arteche; P Muñiz; M Cavia-Saiz; C Garcia-Giron; M García-Gonzalez; Beatriz Llorente-Ayala; M J Coma-Del Corral Journal: Mol Biol Rep Date: 2012-07-08 Impact factor: 2.316
Authors: Judit Kocsis; Balázs Madaras; Eva Katalin Tóth; George Füst; Zoltán Prohászka Journal: Cell Stress Chaperones Date: 2009-07-04 Impact factor: 3.667