Literature DB >> 29844068

Biased G Protein-Coupled Receptor Signaling: Changing the Paradigm of Drug Discovery.

James W Wisler1, Howard A Rockman1,2,3, Robert J Lefkowitz4,5,6.   

Abstract

Entities:  

Keywords:  GTP-binding proteins; cardiovascular agents; heart failure; ligands; receptor, angiotensin, type 1; receptors, adrenergic

Mesh：

Substances：

Year:  2018        PMID： 29844068      PMCID： PMC5984047          DOI： 10.1161/CIRCULATIONAHA.117.028194

Source DB:  PubMed          Journal:  Circulation        ISSN： 0009-7322            Impact factor:   39.918


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  5 in total

1.  β-Arrestin mediates the Frank-Starling mechanism of cardiac contractility.

Authors:  Dennis M Abraham; Robert T Davis; Chad M Warren; Lan Mao; Beata M Wolska; R John Solaro; Howard A Rockman
Journal:  Proc Natl Acad Sci U S A       Date:  2016-11-28       Impact factor: 11.205

2.  Long-Term Biased β-Arrestin Signaling Improves Cardiac Structure and Function in Dilated Cardiomyopathy.

Authors:  David M Ryba; Jieli Li; Conrad L Cowan; Brenda Russell; Beata M Wolska; R John Solaro
Journal:  Circulation       Date:  2017-01-19       Impact factor: 29.690

3.  Structure-based discovery of opioid analgesics with reduced side effects.

Authors:  Aashish Manglik; Henry Lin; Dipendra K Aryal; John D McCorvy; Daniela Dengler; Gregory Corder; Anat Levit; Ralf C Kling; Viachaslau Bernat; Harald Hübner; Xi-Ping Huang; Maria F Sassano; Patrick M Giguère; Stefan Löber; Grégory Scherrer; Brian K Kobilka; Peter Gmeiner; Bryan L Roth; Brian K Shoichet
Journal:  Nature       Date:  2016-08-17       Impact factor: 49.962

4.  A unique mechanism of beta-blocker action: carvedilol stimulates beta-arrestin signaling.

Authors:  James W Wisler; Scott M DeWire; Erin J Whalen; Jonathan D Violin; Matthew T Drake; Seungkirl Ahn; Sudha K Shenoy; Robert J Lefkowitz
Journal:  Proc Natl Acad Sci U S A       Date:  2007-10-09       Impact factor: 11.205

Review 5.  Recent developments in biased agonism.

Authors:  James W Wisler; Kunhong Xiao; Alex R B Thomsen; Robert J Lefkowitz
Journal:  Curr Opin Cell Biol       Date:  2013-11-20       Impact factor: 8.382
  5 in total
  22 in total

1.  Revealing the Activity of Trimeric G-proteins in Live Cells with a Versatile Biosensor Design.

Authors:  Marcin Maziarz; Jong-Chan Park; Anthony Leyme; Arthur Marivin; Alberto Garcia-Lopez; Prachi P Patel; Mikel Garcia-Marcos
Journal:  Cell       Date:  2020-07-06       Impact factor: 41.582

Review 2.  G-Protein-Coupled Receptors in Heart Disease.

Authors:  Jialu Wang; Clarice Gareri; Howard A Rockman
Journal:  Circ Res       Date:  2018-08-31       Impact factor: 17.367

Review 3.  The structural basis of the arrestin binding to GPCRs.

Authors:  Vsevolod V Gurevich; Eugenia V Gurevich
Journal:  Mol Cell Endocrinol       Date:  2019-01-28       Impact factor: 4.102

4.  Sphingosine 1-phosphate-regulated transcriptomes in heterogenous arterial and lymphatic endothelium of the aorta.

Authors:  Eric Engelbrecht; Michel V Levesque; Liqun He; Michael Vanlandewijck; Anja Nitzsche; Hira Niazi; Andrew Kuo; Sasha A Singh; Masanori Aikawa; Kristina Holton; Richard L Proia; Mari Kono; William T Pu; Eric Camerer; Christer Betsholtz; Timothy Hla
Journal:  Elife       Date:  2020-02-24       Impact factor: 8.140

Review 5.  Induced pluripotent stem cells as a platform to understand patient-specific responses to opioids and anaesthetics.

Authors:  Detlef Obal; Joseph C Wu
Journal:  Br J Pharmacol       Date:  2020-08-27       Impact factor: 8.739

6.  A Non-covalent Ligand Reveals Biased Agonism of the TRPA1 Ion Channel.

Authors:  Chang Liu; Rebecca Reese; Simon Vu; Lionel Rougé; Shannon D Shields; Satoko Kakiuchi-Kiyota; Huifen Chen; Kevin Johnson; Yu Patrick Shi; Tania Chernov-Rogan; Demi Maria Zabala Greiner; Pawan Bir Kohli; David Hackos; Bobby Brillantes; Christine Tam; Tianbo Li; Jianyong Wang; Brian Safina; Steve Magnuson; Matthew Volgraf; Jian Payandeh; Jie Zheng; Alexis Rohou; Jun Chen
Journal:  Neuron       Date:  2020-11-04       Impact factor: 17.173

Review 7.  Trends in application of advancing computational approaches in GPCR ligand discovery.

Authors:  Siyu Zhu; Meixian Wu; Ziwei Huang; Jing An
Journal:  Exp Biol Med (Maywood)       Date:  2021-02-27

8.  The Biased Ligands NGF and NT-3 Differentially Stabilize Trk-A Dimers.

Authors:  Fozia Ahmed; Elmer Zapata-Mercado; Sanim Rahman; Kalina Hristova
Journal:  Biophys J       Date:  2020-12-05       Impact factor: 4.033

9.  β-Arrestin-Biased Allosteric Modulator Potentiates Carvedilol-Stimulated β Adrenergic Receptor Cardioprotection.

Authors:  Jialu Wang; Biswaranjan Pani; Ilhan Gokhan; Xinyu Xiong; Alem W Kahsai; Haoran Jiang; Seungkirl Ahn; Robert J Lefkowitz; Howard A Rockman
Journal:  Mol Pharmacol       Date:  2021-09-24       Impact factor: 4.436

10.  The biophysical basis of receptor tyrosine kinase ligand functional selectivity: Trk-B case study.

Authors:  Fozia Ahmed; Michael D Paul; Kalina Hristova
Journal:  Biochem J       Date:  2020-12-11       Impact factor: 3.857
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