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Literature DB >> 32767563

Induced pluripotent stem cells as a platform to understand patient-specific responses to opioids and anaesthetics.

Abstract

Recent advances in human induced pluripotent stem cell (iPSC) technology may provide unprecedented opportunities to study patient-specific responses to anaesthetics and opioids. In this review, we will (1) examine the advantages and limitations of iPSC technology, (2) summarize studies using iPSCs that have contributed to our current understanding of anaesthetics and opioid action on the cardiovascular system and central nervous system (CNS), and (3) describe how iPSC technology can be used to further develop personalized analgesic and sedative pharmacotherapies with reduced or minimal detrimental cardiovascular effects.

Entities: Disease Species

Keywords: anaesthetics; brain; cardiomyocyte; iPSC; ketamine; opioids; propofol

Mesh：

Substances：

Year: 2020 PMID： 32767563 PMCID： PMC7520445 DOI： 10.1111/bph.15228

Source DB: PubMed Journal: Br J Pharmacol ISSN： 0007-1188 Impact factor: 8.739

137 in total

1. Single-channel currents recorded from membrane of denervated frog muscle fibres.

Authors: E Neher; B Sakmann
Journal: Nature Date: 1976-04-29 Impact factor: 49.962

2. Functional cortical neurons and astrocytes from human pluripotent stem cells in 3D culture.

Authors: Anca M Paşca; Steven A Sloan; Laura E Clarke; Yuan Tian; Christopher D Makinson; Nina Huber; Chul Hoon Kim; Jin-Young Park; Nancy A O'Rourke; Khoa D Nguyen; Stephen J Smith; John R Huguenard; Daniel H Geschwind; Ben A Barres; Sergiu P Paşca
Journal: Nat Methods Date: 2015-05-25 Impact factor: 28.547

3. Complex Oscillatory Waves Emerging from Cortical Organoids Model Early Human Brain Network Development.

Authors: Cleber A Trujillo; Richard Gao; Priscilla D Negraes; Jing Gu; Justin Buchanan; Sebastian Preissl; Allen Wang; Wei Wu; Gabriel G Haddad; Isaac A Chaim; Alain Domissy; Matthieu Vandenberghe; Anna Devor; Gene W Yeo; Bradley Voytek; Alysson R Muotri
Journal: Cell Stem Cell Date: 2019-08-29 Impact factor: 24.633

Review 4. GABA A receptors: subtypes provide diversity of function and pharmacology.

Authors: Richard W Olsen; Werner Sieghart
Journal: Neuropharmacology Date: 2008-08-08 Impact factor: 5.250

5. A Human iPSC Double-Reporter System Enables Purification of Cardiac Lineage Subpopulations with Distinct Function and Drug Response Profiles.

Authors: Joe Z Zhang; Vittavat Termglinchan; Ning-Yi Shao; Ilanit Itzhaki; Chun Liu; Ning Ma; Lei Tian; Vicky Y Wang; Alex C Y Chang; Hongchao Guo; Tomoya Kitani; Haodi Wu; Chi Keung Lam; Kazuki Kodo; Nazish Sayed; Helen M Blau; Joseph C Wu
Journal: Cell Stem Cell Date: 2019-03-14 Impact factor: 24.633

6. Novel Adult-Onset Systolic Cardiomyopathy Due to MYH7 E848G Mutation in Patient-Derived Induced Pluripotent Stem Cells.

Authors: Kai-Chun Yang; Astrid Breitbart; Willem J De Lange; Peter Hofsteen; Akiko Futakuchi-Tsuchida; Joy Xu; Cody Schopf; Maria V Razumova; Alex Jiao; Robert Boucek; Lil Pabon; Hans Reinecke; Deok-Ho Kim; J Carter Ralphe; Michael Regnier; Charles E Murry
Journal: JACC Basic Transl Sci Date: 2018-12-31

Review 1. Induced pluripotent stem cells as a platform to understand patient-specific responses to opioids and anaesthetics.

Authors: Detlef Obal; Joseph C Wu
Journal: Br J Pharmacol Date: 2020-08-27 Impact factor: 8.739

2. Increased Retention of Cardiac Cells to a Glass Substrate through Streptavidin-Biotin Affinity.

Authors: Kara A Davis; Jensen Z Goh; Andrea H Sebastian; Brooke M Ahern; Christine A Trinkle; Jonathan Satin; Ahmed Abdel-Latif; Brad J Berron
Journal: ACS Omega Date: 2021-07-01

2 in total

Induced pluripotent stem cells as a platform to understand patient-specific responses to opioids and anaesthetics.

1. Single-channel currents recorded from membrane of denervated frog muscle fibres.

2. Functional cortical neurons and astrocytes from human pluripotent stem cells in 3D culture.

3. Complex Oscillatory Waves Emerging from Cortical Organoids Model Early Human Brain Network Development.

Review 4. GABA A receptors: subtypes provide diversity of function and pharmacology.

5. A Human iPSC Double-Reporter System Enables Purification of Cardiac Lineage Subpopulations with Distinct Function and Drug Response Profiles.

6. Novel Adult-Onset Systolic Cardiomyopathy Due to MYH7 E848G Mutation in Patient-Derived Induced Pluripotent Stem Cells.

Review 7. Organs to Cells and Cells to Organoids: The Evolution of in vitro Central Nervous System Modelling.

8. Individual brain organoids reproducibly form cell diversity of the human cerebral cortex.

Review 9. Synaptic versus extrasynaptic NMDA receptor signalling: implications for neurodegenerative disorders.

10. Postoperative delirium in elderly patients is associated with subsequent cognitive impairment.

Review 1. Induced pluripotent stem cells as a platform to understand patient-specific responses to opioids and anaesthetics.

2. Increased Retention of Cardiac Cells to a Glass Substrate through Streptavidin-Biotin Affinity.