Literature DB >> 2983193

Molecular cloning and chromosomal localization of DNA sequences associated with a human DNA repair gene.

J S Rubin, V R Prideaux, H F Willard, A M Dulhanty, G F Whitmore, A Bernstein.   

Abstract

The genes and gene products involved in the mammalian DNA repair processes have yet to be identified. Toward this end we made use of a number of DNA repair-proficient transformants that were generated after transfection of DNA from repair-proficient human cells into a mutant hamster line that is defective in the initial incision step of the excision repair process. In this report, biochemical evidence is presented that demonstrates that these transformants are repair proficient. In addition, we describe the molecular identification and cloning of unique DNA sequences closely associated with the transfected human DNA repair gene and demonstrate the presence of homologous DNA sequences in human cells and in the repair-proficient DNA transformants. The chromosomal location of these sequences was determined by using a panel of rodent-human somatic cell hybrids. Both unique DNA sequences were found to be on human chromosome 19.

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Year:  1985        PMID： 2983193      PMCID： PMC366723          DOI： 10.1128/mcb.5.2.398-405.1985

Source DB:  PubMed          Journal:  Mol Cell Biol        ISSN： 0270-7306            Impact factor:   4.272


  31 in total

1.  Complementation of the defects of DNA synthesis in irradiated and unirradiated ataxia-telangiectasia cells.

Authors:  J P Murnane; R B Painter
Journal:  Proc Natl Acad Sci U S A       Date:  1982-03       Impact factor: 11.205

2.  Genetic diversity of UV-sensitive DNA repair mutants of Chinese hamster ovary cells.

Authors:  L H Thompson; D B Busch; K Brookman; C L Mooney; D A Glaser
Journal:  Proc Natl Acad Sci U S A       Date:  1981-06       Impact factor: 11.205

3.  DNA repair in a UV-sensitive mutant of a mouse cell line.

Authors:  K Sato; R B Setlow
Journal:  Mutat Res       Date:  1981-12       Impact factor: 2.433

4.  Postirradiation properties of a UV-sensitive variant of CHO.

Authors:  R D Wood; M de Veciana; B Presson-Tincknell
Journal:  Photochem Photobiol       Date:  1982-08       Impact factor: 3.421

5.  Isolation of Chinese hamster ovary cells with reduced unscheduled DNA synthesis after UV irradiation.

Authors:  M Stefanini; A Reuser; D Bootsma
Journal:  Somatic Cell Genet       Date:  1982-09

6.  A sensitive and dependable assay for distinguishing hamster and human X-linked steroid sulfatase activity in somatic cell hybrids.

Authors:  H F Willard; M T Holmes
Journal:  Hum Genet       Date:  1984       Impact factor: 4.132

7.  Human chromosome 13 compensates a DNA repair defect in UV-sensitive mouse cells by mouse--human cell hybridization.

Authors:  T Hori; T Shiomi; K Sato
Journal:  Proc Natl Acad Sci U S A       Date:  1983-09       Impact factor: 11.205

8.  Hypersensitivity to mutation and sister-chromatid-exchange induction in CHO cell mutants defective in incising DNA containing UV lesions.

Authors:  L H Thompson; K W Brookman; L E Dillehay; C L Mooney; A V Carrano
Journal:  Somatic Cell Genet       Date:  1982-11

9.  Molecular identification of a human DNA repair gene following DNA-mediated gene transfer.

Authors:  J S Rubin; A L Joyner; A Bernstein; G F Whitmore
Journal:  Nature       Date:  1983 Nov 10-16       Impact factor: 49.962

10.  Genetic heterogeneity of Fanconi's anemia demonstrated by somatic cell hybrids.

Authors:  S Zakrzewski; K Sperling
Journal:  Hum Genet       Date:  1980       Impact factor: 4.132
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  9 in total

1.  Complementation of a DNA repair defect in xeroderma pigmentosum cells by transfer of human chromosome 9.

Authors:  G P Kaur; R S Athwal
Journal:  Proc Natl Acad Sci U S A       Date:  1989-11       Impact factor: 11.205

2.  Abnormal response to DNA crosslinking agents of Fanconi anemia fibroblasts can be corrected by transfection with normal human DNA.

Authors:  C Diatloff-Zito; D Papadopoulo; D Averbeck; E Moustacchi
Journal:  Proc Natl Acad Sci U S A       Date:  1986-09       Impact factor: 11.205

3.  Regional localization of the phosphoglycerate kinase gene and pseudogene on the human X chromosome and assignment of a related DNA sequence to chromosome 19.

Authors:  H F Willard; S J Goss; M T Holmes; D L Munroe
Journal:  Hum Genet       Date:  1985       Impact factor: 4.132

4.  Genomic characterization of the human DNA excision repair gene ERCC-1.

Authors:  M van Duin; M H Koken; J van den Tol; P ten Dijke; H Odijk; A Westerveld; D Bootsma; J H Hoeijmakers
Journal:  Nucleic Acids Res       Date:  1987-11-25       Impact factor: 16.971

Review 5.  Drug resistance and DNA repair.

Authors:  M Fox; J J Roberts
Journal:  Cancer Metastasis Rev       Date:  1987       Impact factor: 9.264

6.  Repair-deficient xeroderma pigmentosum cells made UV light resistant by fusion with X-ray-inactivated Chinese hamster cells.

Authors:  D Karentz; J E Cleaver
Journal:  Mol Cell Biol       Date:  1986-10       Impact factor: 4.272

7.  Transfection of normal human and Chinese hamster DNA corrects diepoxybutane-induced chromosomal hypersensitivity of Fanconi anemia fibroblasts.

Authors:  M Shaham; B Adler; S Ganguly; R S Chaganti
Journal:  Proc Natl Acad Sci U S A       Date:  1987-08       Impact factor: 11.205

8.  Complementation of the UV-sensitive phenotype of a xeroderma pigmentosum human cell line by transfection with a cDNA clone library.

Authors:  T Teitz; T Naiman; S S Avissar; S Bar; H Okayama; D Canaani
Journal:  Proc Natl Acad Sci U S A       Date:  1987-12       Impact factor: 11.205

9.  A yeast DNA repair gene partially complements defective excision repair in mammalian cells.

Authors:  C Lambert; L B Couto; W A Weiss; R A Schultz; L H Thompson; E C Friedberg
Journal:  EMBO J       Date:  1988-10       Impact factor: 11.598
  9 in total

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