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Literature DB >> 3684592

Genomic characterization of the human DNA excision repair gene ERCC-1.

M van Duin¹, M H Koken, J van den Tol, P ten Dijke, H Odijk, A Westerveld, D Bootsma, J H Hoeijmakers.

Abstract

In this report the genomic characterization of the human excision repair gene ERCC-1 is presented. The gene consists of 10 exons spread over approximately 15 kb. By means of a transfection assay the ERCC-1 promoter was confined to a region of +/- 170 bp upstream of the transcriptional start site. Classical promoter elements like CAAT, TATA and GC-boxes are absent from this region. Furthermore, ERCC-1 transcription is not UV-inducible. A possible explanation is provided for the previously reported alternative splicing of exon VIII. Analysis of ERCC-1 cDNA clones revealed the occurrence of differential polyadenylation which gives ERCC-1 transcripts of 3.4 and 3.8 kb in addition to the major 1.1 kb mRNA. Apparent evolutionary conservation of differential polyadenylation of ERCC-1 transcripts suggests a possible role for this mode of RNA processing in the ERCC-1 repair function.

Entities: Gene Species

Mesh：

Substances：
DNA

Year: 1987 PMID： 3684592 PMCID： PMC306462 DOI： 10.1093/nar/15.22.9195

Source DB: PubMed Journal: Nucleic Acids Res ISSN： 0305-1048 Impact factor: 16.971

41 in total

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24 in total

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