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Literature DB >> 2982724

The human thyroglobulin gene: a polymorphic marker localized distal to C-MYC on chromosome 8 band q24.

F Baas, H Bikker, A Geurts van Kessel, R Melsert, P L Pearson, J J de Vijlder, G J van Ommen.

Abstract

The human thyroglobulin (Tg) gene is localized to chromosome 8 and regionally to band q24 as shown independently by both in situ hybridization techniques and Southern blot analysis of human-rodent somatic cell hybrids. Analysis of hybrids derived from a Burkitt lymphoma, with a translocation breakpoint in the oncogene c-myc, shows that the Tg gene is located distal from c-myc, towards the telomere of the long arm of chromosome 8. The finding of two high frequency restriction fragment length polymorphisms (RFLPs) in the 5' part of the Tg gene results in heterozygosity for at least one marker at chromosome 8, band q24, in 50% of a Caucasian population. These RFLPs cannot only be used for the study of inborn errors in Tg synthesis but also for linkage studies in the telomeric region of chromosome 8q.

Entities: Disease Gene Species

Mesh：

Substances：

Year: 1985 PMID： 2982724 DOI： 10.1007/bf00293284

Source DB: PubMed Journal: Hum Genet ISSN： 0340-6717 Impact factor: 4.132

11 in total

1. Control of thyroglobulin synthesis and secretion. (First of two parts).

Authors: A J Van Herle; G Vassart; J E Dumont
Journal: N Engl J Med Date: 1979-08-02 Impact factor: 91.245

2. Detection of specific sequences among DNA fragments separated by gel electrophoresis.

Authors: E M Southern
Journal: J Mol Biol Date: 1975-11-05 Impact factor: 5.469

3. Labeling deoxyribonucleic acid to high specific activity in vitro by nick translation with DNA polymerase I.

Authors: P W Rigby; M Dieckmann; C Rhodes; P Berg
Journal: J Mol Biol Date: 1977-06-15 Impact factor: 5.469

4. Enzyme electrophoresis on cellulose acetate gel: zymogram patterns in mgh-mouse and man--Chinese hamster somatic cell hybrids.

Authors: P Meera Khan
Journal: Arch Biochem Biophys Date: 1971-08 Impact factor: 4.013

5. Characterization of banding patterns of metaphase-prophase G-banded chromosomes and their use in gene mapping.

Authors: J J Yunis; J R Sawyer; D W Ball
Journal: Cytogenet Cell Genet Date: 1978

6. The human thyroglobulin gene contains two 15-17 kb introns near its 3'-end.

Authors: G J van Ommen; A C Arnberg; F Baas; H Brocas; A Sterk; W H Tegelaers; G Vassart; J J de Vijlder
Journal: Nucleic Acids Res Date: 1983-04-25 Impact factor: 16.971

7. Localization of single copy DNA sequences of G-banded human chromosomes by in situ hybridization.

Authors: M E Harper; G F Saunders
Journal: Chromosoma Date: 1981 Impact factor: 4.316

8. Assignment of adenosine deaminase complexing protein (ADCP) gene(s) to human chromosome 2 in rodent-human somatic cell hybrids.

Authors: E Herbschleb-Voogt; K H Grzeschik; P L Pearson; P Meera Khan
Journal: Hum Genet Date: 1981 Impact factor: 4.132

9. Structural organization of the 3' half of the rat thyroglobulin gene.

Authors: V E Avvedimento; A M Musti; S Obici; S Cocozza; R Di Lauro
Journal: Nucleic Acids Res Date: 1984-04-25 Impact factor: 16.971

10. Unusual scarcity of restriction site polymorphism in the human thyroglobulin gene. A linkage study suggesting autosomal dominance of a defective thyroglobulin allele.

Authors: F Baas; H Bikker; G J van Ommen; J J de Vijlder
Journal: Hum Genet Date: 1984 Impact factor: 4.132

19 in total

1. Genetic mapping of thyroglobulin on bovine chromosome 14.

Authors: T E Daskalchuk; S M Schmutz
Journal: Mamm Genome Date: 1997-01 Impact factor: 2.957

Review 2. Human chromosome 8.

Authors: S Wood
Journal: J Med Genet Date: 1988-11 Impact factor: 6.318

The human thyroglobulin gene: a polymorphic marker localized distal to C-MYC on chromosome 8 band q24.

1. Control of thyroglobulin synthesis and secretion. (First of two parts).

2. Detection of specific sequences among DNA fragments separated by gel electrophoresis.

3. Labeling deoxyribonucleic acid to high specific activity in vitro by nick translation with DNA polymerase I.

4. Enzyme electrophoresis on cellulose acetate gel: zymogram patterns in mgh-mouse and man--Chinese hamster somatic cell hybrids.

5. Characterization of banding patterns of metaphase-prophase G-banded chromosomes and their use in gene mapping.

6. The human thyroglobulin gene contains two 15-17 kb introns near its 3'-end.

7. Localization of single copy DNA sequences of G-banded human chromosomes by in situ hybridization.

8. Assignment of adenosine deaminase complexing protein (ADCP) gene(s) to human chromosome 2 in rodent-human somatic cell hybrids.

9. Structural organization of the 3' half of the rat thyroglobulin gene.

10. Unusual scarcity of restriction site polymorphism in the human thyroglobulin gene. A linkage study suggesting autosomal dominance of a defective thyroglobulin allele.

1. Genetic mapping of thyroglobulin on bovine chromosome 14.

Review 2. Human chromosome 8.

3. A non-radioactive in situ hybridization method based on mercurated nucleic acid probes and sulfhydryl-hapten ligands.

4. Merging autosomal dominance and recessivity.

5. Chromosomal localization of the human proenkephalin and prodynorphin genes.

6. RFLP detected at the 8924 locus by a thyroglobulin cDNA probe.

7. Oncogene amplification in breast cancer.

8. A human gene that restores the DNA-repair defect in SCID mice is located on 8p11.1-->q11.1.

9. Retinoic acid inhibits human thyroid peroxidase and thyroglobulin gene expression in cultured human thyrocytes.

10. The congenital goiter mutation is linked to the thyroglobulin gene in the mouse.