Annukka Holster1, Johanna Teräsjärvi2, Juho Vuononvirta2, Petri Koponen3, Ville Peltola4, Merja Helminen3, Qiushui He2,5, Matti Korppi3, Kirsi Nuolivirta6. 1. Seinäjoki Central Hospital, Hanneksenrinne 7, 60220, Seinäjoki, Finland. 2. Department of Medical Microbiology and Immunology, Turku University, Turku, Finland. 3. Tampere Center for Child Health Research, Tampere University and University Hospital, Tampere, Finland. 4. Department of Pediatrics and Adolescent Medicine, Turku University Hospital and Child and Youth Research Institute, University of Turku, Turku, Finland. 5. Department of Medical Microbiology, Capital Medical University, Beijing, China. 6. Seinäjoki Central Hospital, Hanneksenrinne 7, 60220, Seinäjoki, Finland. kirsi.nuolivirta@fimnet.fi.
Abstract
BACKGROUND: Bronchiolitis is the most common infection leading to hospitalization in infancy. Interleukin-10 (IL-10) is an anti-inflammatory cytokine, and in our previous study, IL10 gene rs1800896 (- 1082A/G) polymorphism was associated with viral etiology of infant bronchiolitis. The objective of this study was to evaluate the associations between IL10 single nucleotide polymorphisms (SNPs) at rs1800890 (- 3575A/T), rs1800871 (- 819C/T) or rs1800872 (- 592C/A) either alone or combined with the SNP at rs1800896 (- 1082G/A), and the etiology and severity of infant bronchiolitis. METHODS: Data on four IL10 SNPs were available from 135 full-term infants, hospitalized for bronchiolitis at age less than 6 months, and from 378 to 400 controls. Viral etiology was studied, and oxygen support, feeding support and the length of stay in hospital were recorded during bronchiolitis hospitalization. RESULTS: Infants with rhinovirus bronchiolitis had the IL10 rs1800890 variant AT or TT genotype less often (18.2%) than controls (63.3%, P = 0.03), and likewise, had the IL10 rs1800896 variant AG or GG genotype less often (27.3%) than controls (65.5%, P = 0.009). Twenty-eight infants with bronchiolitis had the variant-variant Grs1800896Trs1800890 haplotype, and none of them had rhinovirus infection. The IL10 rs1800871 or rs1800872 genotypes showed no associations with viruses. No association was found between any genotypes and bronchiolitis severity measures. CONCLUSION: IL10 rs1800890 and rs1800896 polymorphisms differed between infants with rhinovirus bronchiolitis and controls, but not between infants with respiratory syncytial virus bronchiolitis and controls.
BACKGROUND:Bronchiolitis is the most common infection leading to hospitalization in infancy. Interleukin-10 (IL-10) is an anti-inflammatory cytokine, and in our previous study, IL10 gene rs1800896 (- 1082A/G) polymorphism was associated with viral etiology of infantbronchiolitis. The objective of this study was to evaluate the associations between IL10 single nucleotide polymorphisms (SNPs) at rs1800890 (- 3575A/T), rs1800871 (- 819C/T) or rs1800872 (- 592C/A) either alone or combined with the SNP at rs1800896 (- 1082G/A), and the etiology and severity of infantbronchiolitis. METHODS: Data on four IL10 SNPs were available from 135 full-term infants, hospitalized for bronchiolitis at age less than 6 months, and from 378 to 400 controls. Viral etiology was studied, and oxygen support, feeding support and the length of stay in hospital were recorded during bronchiolitis hospitalization. RESULTS:Infants with rhinovirus bronchiolitis had the IL10 rs1800890 variant AT or TT genotype less often (18.2%) than controls (63.3%, P = 0.03), and likewise, had the IL10 rs1800896 variant AG or GG genotype less often (27.3%) than controls (65.5%, P = 0.009). Twenty-eight infants with bronchiolitis had the variant-variant Grs1800896Trs1800890 haplotype, and none of them had rhinovirus infection. The IL10 rs1800871 or rs1800872 genotypes showed no associations with viruses. No association was found between any genotypes and bronchiolitis severity measures. CONCLUSION:IL10 rs1800890 and rs1800896 polymorphisms differed between infants with rhinovirus bronchiolitis and controls, but not between infants with respiratory syncytial virus bronchiolitis and controls.
Authors: Hai Lee Chung; Woo Taek Kim; Jin Kyung Kim; Eun Jin Choi; Jun Hwa Lee; Gyeong Hoon Lee; Sang Gyung Kim Journal: Ann Allergy Asthma Immunol Date: 2005-02 Impact factor: 6.347
Authors: Berkeley L Bennett; Roberto P Garofalo; Stanley G Cron; Yashoda M Hosakote; Robert L Atmar; Charles G Macias; Pedro A Piedra Journal: J Infect Dis Date: 2007-04-12 Impact factor: 5.226
Authors: Eero Lauhkonen; Petri Koponen; Johanna Teräsjärvi; Kirsi Gröndahl-Yli-Hannuksela; Juho Vuononvirta; Kirsi Nuolivirta; Jyri O Toikka; Merja Helminen; Qiushui He; Matti Korppi Journal: PLoS One Date: 2015-10-16 Impact factor: 3.240
Authors: Anne Kotaniemi-Syrjänen; Raija Vainionpää; Tiina M Reijonen; Matti Waris; Kaj Korhonen; Matti Korppi Journal: J Allergy Clin Immunol Date: 2003-01 Impact factor: 10.793