Literature DB >> 29794058

Cancer metabolism gets physical.

Peter DelNero1, Benjamin D Hopkins2, Lewis C Cantley2, Claudia Fischbach3,4.   

Abstract

Patient-derived culture models enable assessment of drug sensitivity and can connect personalized genomics with therapeutic options. However, their clinical translation is constrained by limited fidelity. We outline how the physical microenvironment regulates cell metabolism and describe how engineered culture systems could enhance the predictive power for precision medicine.
Copyright © 2018 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works.

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Year:  2018        PMID： 29794058      PMCID： PMC5990021          DOI： 10.1126/scitranslmed.aaq1011

Source DB:  PubMed          Journal:  Sci Transl Med        ISSN： 1946-6234            Impact factor:   17.956


  52 in total

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