Literature DB >> 29781479

Substrate mediated redox partner selectivity of cytochrome P450.

Katherine A Gentry1, Meng Zhang, Sang-Choul Im, Lucy Waskell, Ayyalusamy Ramamoorthy.   

Abstract

Investigating the interplay between cytochrome-P450 and its redox partners (CPR and cytochrome-b5) is vital for understanding the metabolism of most hydrophobic drugs. Dynamic structural interactions with the ternary complex, with and without substrates, captured by NMR reveal a gating mechanism for redox partners to promote P450 function.

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Year:  2018        PMID： 29781479      PMCID： PMC5980791          DOI： 10.1039/c8cc02525h

Source DB:  PubMed          Journal:  Chem Commun (Camb)        ISSN： 1359-7345            Impact factor:   6.222


  33 in total

Review 1.  Function of human cytochrome P450s: characterization of the orphans.

Authors:  F Peter Guengerich; Zhong-Liu Wu; Cheryl J Bartleson
Journal:  Biochem Biophys Res Commun       Date:  2005-08-22       Impact factor: 3.575

Review 2.  Cytochrome P450 structure-function: insights from molecular dynamics simulations.

Authors:  Pramod C Nair; Ross A McKinnon; John O Miners
Journal:  Drug Metab Rev       Date:  2016-05-10       Impact factor: 4.518

3.  Identification of the binding site on cytochrome P450 2B4 for cytochrome b5 and cytochrome P450 reductase.

Authors:  A Bridges; L Gruenke; Y T Chang; I A Vakser; G Loew; L Waskell
Journal:  J Biol Chem       Date:  1998-07-03       Impact factor: 5.157

4.  Reconstitution of the Cytb5-CytP450 Complex in Nanodiscs for Structural Studies using NMR Spectroscopy.

Authors:  Meng Zhang; Rui Huang; Rose Ackermann; Sang-Choul Im; Lucy Waskell; Anna Schwendeman; Ayyalusamy Ramamoorthy
Journal:  Angew Chem Int Ed Engl       Date:  2016-02-29       Impact factor: 15.336

Review 5.  The interaction of microsomal cytochrome P450 2B4 with its redox partners, cytochrome P450 reductase and cytochrome b(5).

Authors:  Sang-Choul Im; Lucy Waskell
Journal:  Arch Biochem Biophys       Date:  2010-11-03       Impact factor: 4.013

6.  Effect of redox partner binding on CYP101D1 conformational dynamics.

Authors:  Dipanwita Batabyal; Thomas L Poulos
Journal:  J Inorg Biochem       Date:  2018-03-01       Impact factor: 4.155

Review 7.  The many roles of cytochrome b5.

Authors:  John B Schenkman; Ingela Jansson
Journal:  Pharmacol Ther       Date:  2003-02       Impact factor: 12.310

8.  Cytochrome b5 increases the rate of product formation by cytochrome P450 2B4 and competes with cytochrome P450 reductase for a binding site on cytochrome P450 2B4.

Authors:  Haoming Zhang; Sang-Choul Im; Lucy Waskell
Journal:  J Biol Chem       Date:  2007-08-10       Impact factor: 5.157

Review 9.  Cytochrome p450 and chemical toxicology.

Authors:  F Peter Guengerich
Journal:  Chem Res Toxicol       Date:  2007-12-06       Impact factor: 3.739

Review 10.  The catalytic function of cytochrome P450 is entwined with its membrane-bound nature.

Authors:  Carlo Barnaba; Katherine Gentry; Nirupama Sumangala; Ayyalusamy Ramamoorthy
Journal:  F1000Res       Date:  2017-05-09
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  7 in total

1.  Probing protein-protein and protein-substrate interactions in the dynamic membrane-associated ternary complex of cytochromes P450, b5, and reductase.

Authors:  Katherine A Gentry; G M Anantharamaiah; Ayyalusamy Ramamoorthy
Journal:  Chem Commun (Camb)       Date:  2019-10-22       Impact factor: 6.222

2.  Measurement of Residual Dipolar Couplings Using Magnetically Aligned and Flipped Nanodiscs.

Authors:  Thirupathi Ravula; Ayyalusamy Ramamoorthy
Journal:  Langmuir       Date:  2021-12-29       Impact factor: 4.331

3.  Lipid-exchange in nanodiscs discloses membrane boundaries of cytochrome-P450 reductase.

Authors:  Carlo Barnaba; Thirupathi Ravula; Ilce G Medina-Meza; Sang-Choul Im; G M Anantharamaiah; Lucy Waskell; Ayyalusamy Ramamoorthy
Journal:  Chem Commun (Camb)       Date:  2018-06-14       Impact factor: 6.222

4.  The Role of the FMN-Domain of Human Cytochrome P450 Oxidoreductase in Its Promiscuous Interactions With Structurally Diverse Redox Partners.

Authors:  Francisco Esteves; Diana Campelo; Bruno Costa Gomes; Philippe Urban; Sophie Bozonnet; Thomas Lautier; José Rueff; Gilles Truan; Michel Kranendonk
Journal:  Front Pharmacol       Date:  2020-03-18       Impact factor: 5.810

5.  Differential effects on human cytochromes P450 by CRISPR/Cas9-induced genetic knockout of cytochrome P450 reductase and cytochrome b5 in HepaRG cells.

Authors:  Tamara Heintze; Kathrin Klein; Ute Hofmann; Ulrich M Zanger
Journal:  Sci Rep       Date:  2021-01-13       Impact factor: 4.379

6.  Functional Assembly of Caenorhabditis elegans Cytochrome b-2 (Cecytb-2) into Phospholipid Bilayer Nanodisc with Enhanced Iron Reductase Activity.

Authors:  Hamed A Abosharaf; Yuki Sakamoto; Aliaa M Radwan; Keisuke Yuzu; Mika Fujimura; Thoria Diab; Tarek M Mohamed; Eri Chatani; Tetsunari Kimura; Motonari Tsubaki
Journal:  Biomolecules       Date:  2021-01-13

7.  Structural Dynamics of Cytochrome P450 3A4 in the Presence of Substrates and Cytochrome P450 Reductase.

Authors:  Julie Ducharme; Irina F Sevrioukova; Christopher J Thibodeaux; Karine Auclair
Journal:  Biochemistry       Date:  2021-07-01       Impact factor: 3.321
  7 in total

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