Literature DB >> 29863198

Lipid-exchange in nanodiscs discloses membrane boundaries of cytochrome-P450 reductase.

Carlo Barnaba1, Thirupathi Ravula, Ilce G Medina-Meza, Sang-Choul Im, G M Anantharamaiah, Lucy Waskell, Ayyalusamy Ramamoorthy.   

Abstract

Lipids are critical for the function of membrane proteins. NADPH-cytochrome-P450-reductase, the sole electron transferase for microsomal oxygenases, possesses a conformational dynamics entwined with its topology. Here, we use peptide-nanodiscs to unveil cytochrome-P450-reductase's lipid boundaries, demonstrating a protein-driven enrichment of ethanolamine lipids (by 25%) which ameliorates by 3-fold CPR's electron-transfer ability.

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Year:  2018        PMID： 29863198      PMCID： PMC6022741          DOI： 10.1039/c8cc02003e

Source DB:  PubMed          Journal:  Chem Commun (Camb)        ISSN： 1359-7345            Impact factor:   6.222


  32 in total

Review 1.  How proteins produce cellular membrane curvature.

Authors:  Joshua Zimmerberg; Michael M Kozlov
Journal:  Nat Rev Mol Cell Biol       Date:  2006-01       Impact factor: 94.444

2.  Detergent-resistant membranes should not be identified with membrane rafts.

Authors:  Dov Lichtenberg; Félix M Goñi; Heiko Heerklotz
Journal:  Trends Biochem Sci       Date:  2005-08       Impact factor: 13.807

3.  Time-resolved fluorescence spectroscopy of NADPH-cytochrome P-450 reductase: demonstration of energy transfer between the two prosthetic groups.

Authors:  P I Bastiaens; P J Bonants; F Müller; A J Visser
Journal:  Biochemistry       Date:  1989-10-17       Impact factor: 3.162

4.  Single-Protein Tracking Reveals That NADPH Mediates the Insertion of Cytochrome P450 Reductase into a Biomimetic of the Endoplasmic Reticulum.

Authors:  Carlo Barnaba; Michael J Martinez; Evan Taylor; Adam O Barden; James A Brozik
Journal:  J Am Chem Soc       Date:  2017-04-06       Impact factor: 15.419

5.  Application of methyl-TROSY to a large paramagnetic membrane protein without perdeuteration: 13C-MMTS-labeled NADPH-cytochrome P450 oxidoreductase.

Authors:  Azamat R Galiakhmetov; Elizaveta A Kovrigina; Chuanwu Xia; Jung-Ja P Kim; Evgenii L Kovrigin
Journal:  J Biomol NMR       Date:  2017-11-22       Impact factor: 2.835

Review 6.  Lipid polymorphism and protein-lipid interactions.

Authors:  R M Epand
Journal:  Biochim Biophys Acta       Date:  1998-11-10

7.  A specific interaction between NADPH-cytochrome reductase and phosphatidylserine and phosphatidylinositol.

Authors:  W G Balvers; M G Boersma; J Vervoort; A Ouwehand; I M Rietjens
Journal:  Eur J Biochem       Date:  1993-12-15

Review 8.  The catalytic function of cytochrome P450 is entwined with its membrane-bound nature.

Authors:  Carlo Barnaba; Katherine Gentry; Nirupama Sumangala; Ayyalusamy Ramamoorthy
Journal:  F1000Res       Date:  2017-05-09

9.  Fast Collisional Lipid Transfer Among Polymer-Bounded Nanodiscs.

Authors:  Rodrigo Cuevas Arenas; Bartholomäus Danielczak; Anne Martel; Lionel Porcar; Cécile Breyton; Christine Ebel; Sandro Keller
Journal:  Sci Rep       Date:  2017-04-05       Impact factor: 4.379

10.  Direct observation of multiple conformational states in Cytochrome P450 oxidoreductase and their modulation by membrane environment and ionic strength.

Authors:  Krutika Bavishi; Darui Li; Stine Eiersholt; Emma N Hooley; Troels C Petersen; Birger Lindberg Møller; Nikos S Hatzakis; Tomas Laursen
Journal:  Sci Rep       Date:  2018-05-01       Impact factor: 4.379
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  4 in total

1.  Measuring Remodeling of the Lipid Environment Surrounding Membrane Proteins with Lipid Exchange and Native Mass Spectrometry.

Authors:  Guozhi Zhang; James E Keener; Michael T Marty
Journal:  Anal Chem       Date:  2020-04-07       Impact factor: 6.986

2.  Detergent-free isolation of CYP450-reductase's FMN-binding domain in E. coli lipid-nanodiscs using a charge-free polymer.

Authors:  Bankala Krishnarjuna; Thirupathi Ravula; Ayyalusamy Ramamoorthy
Journal:  Chem Commun (Camb)       Date:  2022-04-14       Impact factor: 6.065

3.  The apoA-I mimetic peptide 4F protects apolipoprotein A-I from oxidative damage.

Authors:  C Roger White; Geeta Datta; Landon Wilson; Mayakonda N Palgunachari; G M Anantharamaiah
Journal:  Chem Phys Lipids       Date:  2019-01-29       Impact factor: 3.329

4.  Biased cytochrome P450-mediated metabolism via small-molecule ligands binding P450 oxidoreductase.

Authors:  Simon Bo Jensen; Sara Thodberg; Shaheena Parween; Matias E Moses; Cecilie C Hansen; Johannes Thomsen; Magnus B Sletfjerding; Camilla Knudsen; Rita Del Giudice; Philip M Lund; Patricia R Castaño; Yanet G Bustamante; Maria Natalia Rojas Velazquez; Flemming Steen Jørgensen; Amit V Pandey; Tomas Laursen; Birger Lindberg Møller; Nikos S Hatzakis
Journal:  Nat Commun       Date:  2021-04-15       Impact factor: 14.919
  4 in total

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