M Hamer1,2, N Sharma3, G D Batty2. 1. School Sport, Exercise & Health Sciences, Loughborough University, Loughborough, UK. 2. Department of Epidemiology and Public Health, University College London, London, UK. 3. MRC Unit for Lifelong Health and Ageing, University College London, London, UK.
Abstract
BACKGROUND: Physical activity may be beneficial for cognition but mechanisms are unclear. We examined the association between objectively assessed physical activity and brain volume, with a focus on the hippocampus region. METHODS: We used data from UK Biobank (n = 5272; aged 55.4 ± 7.5 years; 45.6% men) collected through 2013-2016. Participants wore the Axivity AX3 wrist-worn triaxial accelerometer for 7 days to assess habitual physical activity. Structural magnetic resonance imaging was performed using a standard Siemens Skyra 3T running VD13A SP4 to obtain images of the brain. RESULTS: There was an association between physical activity (per SD increase) and grey matter volume after adjustment for a range of covariates, although this association was only detected in older adults (>60 years old). We also observed associations of physical activity with both left (B = 0.52, 95% CI, 0.01, 1.03; P = 0.046) and right hippocampal volume (B = 0.59, 95% CI, 0.08, 1.10; P = 0.024) in covariate-adjusted models. CONCLUSION: In summary, physical activity may play a role in the prevention of neurodegenerative diseases.
BACKGROUND: Physical activity may be beneficial for cognition but mechanisms are unclear. We examined the association between objectively assessed physical activity and brain volume, with a focus on the hippocampus region. METHODS: We used data from UK Biobank (n = 5272; aged 55.4 ± 7.5 years; 45.6% men) collected through 2013-2016. Participants wore the Axivity AX3 wrist-worn triaxial accelerometer for 7 days to assess habitual physical activity. Structural magnetic resonance imaging was performed using a standard Siemens Skyra 3T running VD13A SP4 to obtain images of the brain. RESULTS: There was an association between physical activity (per SD increase) and grey matter volume after adjustment for a range of covariates, although this association was only detected in older adults (>60 years old). We also observed associations of physical activity with both left (B = 0.52, 95% CI, 0.01, 1.03; P = 0.046) and right hippocampal volume (B = 0.59, 95% CI, 0.08, 1.10; P = 0.024) in covariate-adjusted models. CONCLUSION: In summary, physical activity may play a role in the prevention of neurodegenerative diseases.
Authors: Benjamin Sinclair; Chris Steward; Vijay Venkatraman; Rowa Aljondi; Kay L Cox; Kathryn A Ellis; David Ames; Colin L Masters; Pramit M Phal; Matthew J Sharman; Elizabeth V Cyarto; Michelle M Y Lai; Cassandra Szoeke; Nicola T Lautenschlager; Patricia M Desmond Journal: Brain Imaging Behav Date: 2021-11-10 Impact factor: 3.978
Authors: Fabienne A U Fox; Kersten Diers; Hweeling Lee; Andreas Mayr; Martin Reuter; Monique M B Breteler; N Ahmad Aziz Journal: Neurology Date: 2022-08-02 Impact factor: 11.800
Authors: Erin E Dooley; Priya Palta; Dana L Wolff-Hughes; Pablo Martinez-Amezcua; John Staudenmayer; Richard P Troiano; Kelley Pettee Gabriel Journal: Med Sci Sports Exerc Date: 2022-04-06
Authors: Amal A Wanigatunga; Hang Wang; Yang An; Eleanor M Simonsick; Qu Tian; Christos Davatzikos; Jacek K Urbanek; Vadim Zipunnikov; Adam P Spira; Luigi Ferrucci; Susan M Resnick; Jennifer A Schrack Journal: J Gerontol A Biol Sci Med Sci Date: 2021-07-13 Impact factor: 6.053
Authors: Priya Palta; A Richey Sharrett; Kelley Pettee Gabriel; Rebecca F Gottesman; Aaron R Folsom; Melinda C Power; Kelly R Evenson; Clifford R Jack; David S Knopman; Thomas H Mosley; Gerardo Heiss Journal: Neurology Date: 2021-01-06 Impact factor: 9.910
Authors: Nicole L Spartano; Kendra L Davis-Plourde; Jayandra J Himali; Charlotte Andersson; Matthew P Pase; Pauline Maillard; Charles DeCarli; Joanne M Murabito; Alexa S Beiser; Ramachandran S Vasan; Sudha Seshadri Journal: JAMA Netw Open Date: 2019-04-05
Authors: Sarah L Aghjayan; Alina Lesnovskaya; Irene Esteban-Cornejo; Jamie C Peven; Chelsea M Stillman; Kirk I Erickson Journal: Hippocampus Date: 2021-06-08 Impact factor: 3.753