| Literature DB >> 34757564 |
Benjamin Sinclair1,2,3,4, Chris Steward5,6, Vijay Venkatraman5,6, Rowa Aljondi5,6,7, Kay L Cox8, Kathryn A Ellis9,10, David Ames9, Colin L Masters11, Pramit M Phal5,6, Matthew J Sharman12, Elizabeth V Cyarto13,14, Michelle M Y Lai9,15, Cassandra Szoeke6, Nicola T Lautenschlager6,9,16, Patricia M Desmond5,6.
Abstract
Lack of physical activity is a risk factor for dementia, however, the utility of interventional physical activity programs as a protective measure against brain atrophy and cognitive decline is uncertain. Here we present the effect of a randomized controlled trial of a 24-month physical activity intervention on global and regional brain atrophy as characterized by longitudinal voxel-based morphometry with T1-weighted MRI images. The study sample consisted of 98 participants at risk of dementia, with mild cognitive impairment or subjective memory complaints, and having at least one vascular risk factor for dementia, randomized into an exercise group and a control group. Between 0 and 24 months, there was no significant difference detected between groups in the rate of change in global, or regional brain volumes.Entities:
Keywords: Brain volume; Dementia; Mild cognitive impairment; Physical activity; Voxel-based Morphometry
Mesh：
Year: 2021 PMID： 34757564 DOI： 10.1007/s11682-021-00577-7
Source DB: PubMed Journal: Brain Imaging Behav ISSN： 1931-7557 Impact factor: 3.978