Literature DB >> 29774342

The distinct structural preferences of tau protein repeat domains.

Xuhua Li1, Xuewei Dong, Guanghong Wei, Martin Margittai, Ruth Nussinov, Buyong Ma.   

Abstract

The tau fibrillar structures from the brain of an Alzheimer's patient have a core with a C-shaped motif of the third and fourth repeat domains (R3-R4). Our simulations indicated that the C-shaped motif is only stable for R3-R4, while R1-R2 tends to be linear in shape. These two structural motifs appear in the most stable K18 protofilament. Heparin can further stabilize the C-shaped R3-R4 motif, but not other repeats.

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Year:  2018        PMID： 29774342      PMCID： PMC5986281          DOI： 10.1039/c8cc01263f

Source DB:  PubMed          Journal:  Chem Commun (Camb)        ISSN： 1359-7345            Impact factor:   6.222


  22 in total

1.  Microtubule-Binding R3 Fragment from Tau Self-Assembles into Giant Multistranded Amyloid Ribbons.

Authors:  Jozef Adamcik; Antoni Sánchez-Ferrer; Nadine Ait-Bouziad; Nicholas P Reynolds; Hilal A Lashuel; Raffaele Mezzenga
Journal:  Angew Chem Int Ed Engl       Date:  2015-12-04       Impact factor: 15.336

2.  Straight and paired helical filaments in Alzheimer disease have a common structural unit.

Authors:  R A Crowther
Journal:  Proc Natl Acad Sci U S A       Date:  1991-03-15       Impact factor: 11.205

3.  Polymerization of tau into filaments in the presence of heparin: the minimal sequence required for tau-tau interaction.

Authors:  M Pérez; J M Valpuesta; M Medina; E Montejo de Garcini; J Avila
Journal:  J Neurochem       Date:  1996-09       Impact factor: 5.372

4.  Structural impact of heparin binding to full-length Tau as studied by NMR spectroscopy.

Authors:  Nathalie Sibille; Alain Sillen; Arnaud Leroy; Jean-Michel Wieruszeski; Barbara Mulloy; Isabelle Landrieu; Guy Lippens
Journal:  Biochemistry       Date:  2006-10-17       Impact factor: 3.162

5.  Molecular insights into the reversible formation of tau protein fibrils.

Authors:  Yin Luo; Paul Dinkel; Xiang Yu; Martin Margittai; Jie Zheng; Ruth Nussinov; Guanghong Wei; Buyong Ma
Journal:  Chem Commun (Camb)       Date:  2013-05-04       Impact factor: 6.222

6.  Structural characterization of the core of the paired helical filament of Alzheimer disease.

Authors:  C M Wischik; M Novak; P C Edwards; A Klug; W Tichelaar; R A Crowther
Journal:  Proc Natl Acad Sci U S A       Date:  1988-07       Impact factor: 11.205

Review 7.  Tau-based therapies in neurodegeneration: opportunities and challenges.

Authors:  Chuanzhou Li; Jürgen Götz
Journal:  Nat Rev Drug Discov       Date:  2017-10-06       Impact factor: 84.694

8.  A complex mechanism for inducer mediated tau polymerization.

Authors:  Shaun W Carlson; Mike Branden; Kellen Voss; Qian Sun; Carolyn A Rankin; T Chris Gamblin
Journal:  Biochemistry       Date:  2007-07-04       Impact factor: 3.162

9.  Synergistic interactions between repeats in tau protein and Aβ amyloids may be responsible for accelerated aggregation via polymorphic states.

Authors:  Yifat Miller; Buyong Ma; Ruth Nussinov
Journal:  Biochemistry       Date:  2011-05-18       Impact factor: 3.162

10.  Conformational basis for asymmetric seeding barrier in filaments of three- and four-repeat tau.

Authors:  Ayisha Siddiqua; Yin Luo; Virginia Meyer; Michael A Swanson; Xiang Yu; Guanghong Wei; Jie Zheng; Gareth R Eaton; Buyong Ma; Ruth Nussinov; Sandra S Eaton; Martin Margittai
Journal:  J Am Chem Soc       Date:  2012-06-12       Impact factor: 15.419
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  4 in total

Review 1.  Amyloid Oligomers: A Joint Experimental/Computational Perspective on Alzheimer's Disease, Parkinson's Disease, Type II Diabetes, and Amyotrophic Lateral Sclerosis.

Authors:  Phuong H Nguyen; Ayyalusamy Ramamoorthy; Bikash R Sahoo; Jie Zheng; Peter Faller; John E Straub; Laura Dominguez; Joan-Emma Shea; Nikolay V Dokholyan; Alfonso De Simone; Buyong Ma; Ruth Nussinov; Saeed Najafi; Son Tung Ngo; Antoine Loquet; Mara Chiricotto; Pritam Ganguly; James McCarty; Mai Suan Li; Carol Hall; Yiming Wang; Yifat Miller; Simone Melchionna; Birgit Habenstein; Stepan Timr; Jiaxing Chen; Brianna Hnath; Birgit Strodel; Rakez Kayed; Sylvain Lesné; Guanghong Wei; Fabio Sterpone; Andrew J Doig; Philippe Derreumaux
Journal:  Chem Rev       Date:  2021-02-05       Impact factor: 60.622

2.  Misfolding and Self-Assembly Dynamics of Microtubule-Binding Repeats of the Alzheimer-Related Protein Tau.

Authors:  Huan He; Yuying Liu; Yunxiang Sun; Feng Ding
Journal:  J Chem Inf Model       Date:  2021-05-25       Impact factor: 6.162

3.  Pre-clinical characterisation of E2814, a high-affinity antibody targeting the microtubule-binding repeat domain of tau for passive immunotherapy in Alzheimer's disease.

Authors:  Malcolm Roberts; Ioanna Sevastou; Yoichi Imaizumi; Kavita Mistry; Sonia Talma; Madhurima Dey; Jane Gartlon; Hiroshi Ochiai; Zhi Zhou; Shigeru Akasofu; Naoki Tokuhara; Makoto Ogo; Muneo Aoyama; Hirofumi Aoyagi; Kate Strand; Ezat Sajedi; Kishan Lal Agarwala; Jared Spidel; Earl Albone; Kanta Horie; James M Staddon; Rohan de Silva
Journal:  Acta Neuropathol Commun       Date:  2020-02-04       Impact factor: 7.801

4.  Insight Into Seeded Tau Fibril Growth From Molecular Dynamics Simulation of the Alzheimer's Disease Protofibril Core.

Authors:  Cass Leonard; Christian Phillips; James McCarty
Journal:  Front Mol Biosci       Date:  2021-03-19
  4 in total

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