| Literature DB >> 29737194 |
Silvia Ratto-Kim1,2, Alexandra Schuetz1,2,3, Pasiri Sithinamsuwan4, John Barber5, Nicholas Hutchings6, Sukalaya Lerdlum7, James L K Fletcher8, Yuwadee Phuang-Ngern3, Weerawan Chuenarom3, Somporn Tipsuk8, Mantana Pothisri7, Tanate Jadwattanakul9, Supunnee Jirajariyavej10, Chayada Sajjaweerawan3, Siriwat Akapirat3, Thep Chalermchai8, Duanghathai Suttichom8, Boot Kaewboon3, Peeriya Prueksakaew8, Putthachard Karnsomlap8, David Clifford11, Robert H Paul11, Mark S de Souza8, Jerome H Kim12, Jintanat Ananworanich1,2,8, Victor Valcour13.
Abstract
HIV-associated neurocognitive disorder (HAND) remains a challenge despite antiretroviral therapy (ART), and has been linked to monocyte/macrophage (M/M) migration to the brain. Due to the potential impact of T cell effector mechanisms in eliminating activated/HIV-infected M/M, T cell activation may play a role in the development of HAND. We sought to investigate the relationship between cognition and both CD8+ T cell activation (HLA-DR+/CD38+) and HIV-specific CD8+ T cell responses at the time of HIV diagnosis and 12 months postinitiation of ART. CD8+ T cell activation was increased in HAND compared to cognitive normal (NL) individuals and correlated directly with plasma viral load and inversely with the cognitive status. In addition, Gag-specific cytolytic activity (CD107a/b+) was decreased in HAND compared with NL individuals and correlated with their neurological testing, suggesting a potential role of cytotoxic CD8+ T cells in the mechanism of HAND development.Entities:
Keywords: CD8+ T cell activation; HIV-associated neurocognitive disorders; HIV-specific cytolytic T cells
Mesh：
Year: 2018 PMID： 29737194 PMCID： PMC6080108 DOI： 10.1089/AID.2017.0237
Source DB: PubMed Journal: AIDS Res Hum Retroviruses ISSN： 0889-2229 Impact factor: 2.205