Literature DB >> 23035225

Development of neurological disease is associated with increased immune activation in simian immunodeficiency virus-infected macaques.

Que Dang1, Sonya Whitted, Robert M Goeken, Jason M Brenchley, Kenta Matsuda, Charles R Brown, Bernard A P Lafont, Matthew F Starost, Ranjini Iyengar, Ronald J Plishka, Alicia Buckler-White, Vanessa M Hirsch.   

Abstract

Simian immunodeficiency virus (SIV) infection of macaques can result in central nervous system disorders, such as meningitis and encephalitis. We studied 10 animals inoculated with brain-derived virus from animals with SIV encephalitis. Over half of the macaques developed SIV-induced neurologic disease. Elevated levels of systemic immune activation were observed to correlate with viral RNA in the cerebral spinal fluid but not with plasma viral load, consistent with a role for SIV in the pathogenesis of neurologic disease.

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Year:  2012        PMID： 23035225      PMCID： PMC3503031          DOI： 10.1128/JVI.02174-12

Source DB:  PubMed          Journal:  J Virol        ISSN： 0022-538X            Impact factor:   5.103


  14 in total

Review 1.  Neurobiology of simian and feline immunodeficiency virus infections.

Authors:  A A Lackner; S Dandekar; M B Gardner
Journal:  Brain Pathol       Date:  1991-04       Impact factor: 6.508

2.  Pathogenesis of SIV encephalitis. Selection and replication of neurovirulent SIV.

Authors:  M C Zink; A M Amedee; J L Mankowski; L Craig; P Didier; D L Carter; A Muñoz; M Murphey-Corb; J E Clements
Journal:  Am J Pathol       Date:  1997-09       Impact factor: 4.307

3.  Elevated CD38 antigen expression on CD8+ T cells is a stronger marker for the risk of chronic HIV disease progression to AIDS and death in the Multicenter AIDS Cohort Study than CD4+ cell count, soluble immune activation markers, or combinations of HLA-DR and CD38 expression.

Authors:  Z Liu; W G Cumberland; L E Hultin; H E Prince; R Detels; J V Giorgi
Journal:  J Acquir Immune Defic Syndr Hum Retrovirol       Date:  1997-10-01

4.  Immunologic and virologic events in early HIV infection predict subsequent rate of progression.

Authors:  Anuradha Ganesan; Pratip K Chattopadhyay; Tess M Brodie; Jing Qin; Wenjuan Gu; John R Mascola; Nelson L Michael; Dean A Follmann; Mario Roederer
Journal:  J Infect Dis       Date:  2010-01-15       Impact factor: 5.226

5.  Compromised gastrointestinal integrity in pigtail macaques is associated with increased microbial translocation, immune activation, and IL-17 production in the absence of SIV infection.

Authors:  N R Klatt; L D Harris; C L Vinton; H Sung; J A Briant; B Tabb; D Morcock; J W McGinty; J D Lifson; B A Lafont; M A Martin; A D Levine; J D Estes; J M Brenchley
Journal:  Mucosal Immunol       Date:  2010-03-31       Impact factor: 7.313

Review 6.  The brain in AIDS: central nervous system HIV-1 infection and AIDS dementia complex.

Authors:  R W Price; B Brew; J Sidtis; M Rosenblum; A C Scheck; P Cleary
Journal:  Science       Date:  1988-02-05       Impact factor: 47.728

7.  Relationship between T cell activation and CD4+ T cell count in HIV-seropositive individuals with undetectable plasma HIV RNA levels in the absence of therapy.

Authors:  Peter W Hunt; Jason Brenchley; Elizabeth Sinclair; Joseph M McCune; Michelle Roland; Kimberly Page-Shafer; Priscilla Hsue; Brinda Emu; Melissa Krone; Harry Lampiris; Daniel Douek; Jeffrey N Martin; Steven G Deeks
Journal:  J Infect Dis       Date:  2008-01-01       Impact factor: 5.226

8.  Isolation of HTLV-III from cerebrospinal fluid and neural tissues of patients with neurologic syndromes related to the acquired immunodeficiency syndrome.

Authors:  D D Ho; T R Rota; R T Schooley; J C Kaplan; J D Allan; J E Groopman; L Resnick; D Felsenstein; C A Andrews; M S Hirsch
Journal:  N Engl J Med       Date:  1985-12-12       Impact factor: 91.245

9.  Microbial translocation is a cause of systemic immune activation in chronic HIV infection.

Authors:  Jason M Brenchley; David A Price; Timothy W Schacker; Tedi E Asher; Guido Silvestri; Srinivas Rao; Zachary Kazzaz; Ethan Bornstein; Olivier Lambotte; Daniel Altmann; Bruce R Blazar; Benigno Rodriguez; Leia Teixeira-Johnson; Alan Landay; Jeffrey N Martin; Frederick M Hecht; Louis J Picker; Michael M Lederman; Steven G Deeks; Daniel C Douek
Journal:  Nat Med       Date:  2006-11-19       Impact factor: 53.440

10.  Microbial translocation is associated with increased monocyte activation and dementia in AIDS patients.

Authors:  Petronela Ancuta; Anupa Kamat; Kevin J Kunstman; Eun-Young Kim; Patrick Autissier; Alysse Wurcel; Tauheed Zaman; David Stone; Megan Mefford; Susan Morgello; Elyse J Singer; Steven M Wolinsky; Dana Gabuzda
Journal:  PLoS One       Date:  2008-06-25       Impact factor: 3.240
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  10 in total

1.  Characterization of Cellular Immune Responses in Thai Individuals With and Without HIV-Associated Neurocognitive Disorders.

Authors:  Silvia Ratto-Kim; Alexandra Schuetz; Pasiri Sithinamsuwan; John Barber; Nicholas Hutchings; Sukalaya Lerdlum; James L K Fletcher; Yuwadee Phuang-Ngern; Weerawan Chuenarom; Somporn Tipsuk; Mantana Pothisri; Tanate Jadwattanakul; Supunnee Jirajariyavej; Chayada Sajjaweerawan; Siriwat Akapirat; Thep Chalermchai; Duanghathai Suttichom; Boot Kaewboon; Peeriya Prueksakaew; Putthachard Karnsomlap; David Clifford; Robert H Paul; Mark S de Souza; Jerome H Kim; Jintanat Ananworanich; Victor Valcour
Journal:  AIDS Res Hum Retroviruses       Date:  2018-06-12       Impact factor: 2.205

Review 2.  Brain PET Imaging: Value for Understanding the Pathophysiology of HIV-associated Neurocognitive Disorder (HAND).

Authors:  Sanhita Sinharay; Dima A Hammoud
Journal:  Curr HIV/AIDS Rep       Date:  2019-02       Impact factor: 5.071

3.  Characterization of simian immunodeficiency virus (SIV) that induces SIV encephalitis in rhesus macaques with high frequency: role of TRIM5 and major histocompatibility complex genotypes and early entry to the brain.

Authors:  Kenta Matsuda; Que Dang; Charles R Brown; Brandon F Keele; Fan Wu; Ilnour Ourmanov; Robert Goeken; Sonya Whitted; Nadeene E Riddick; Alicia Buckler-White; Vanessa M Hirsch
Journal:  J Virol       Date:  2014-09-03       Impact factor: 5.103

4.  Enhanced antagonism of BST-2 by a neurovirulent SIV envelope.

Authors:  Kenta Matsuda; Chia-Yen Chen; Sonya Whitted; Elena Chertova; David J Roser; Fan Wu; Ronald J Plishka; Ilnour Ourmanov; Alicia Buckler-White; Jeffrey D Lifson; Klaus Strebel; Vanessa M Hirsch
Journal:  J Clin Invest       Date:  2016-05-09       Impact factor: 14.808

5.  Tissue myeloid cells in SIV-infected primates acquire viral DNA through phagocytosis of infected T cells.

Authors:  Nina Calantone; Fan Wu; Zachary Klase; Claire Deleage; Molly Perkins; Kenta Matsuda; Elizabeth A Thompson; Alexandra M Ortiz; Carol L Vinton; Ilnour Ourmanov; Karin Loré; Daniel C Douek; Jacob D Estes; Vanessa M Hirsch; Jason M Brenchley
Journal:  Immunity       Date:  2014-09-18       Impact factor: 31.745

Review 6.  Macrophages in Progressive Human Immunodeficiency Virus/Simian Immunodeficiency Virus Infections.

Authors:  Sarah R DiNapoli; Vanessa M Hirsch; Jason M Brenchley
Journal:  J Virol       Date:  2016-08-12       Impact factor: 5.103

7.  Laser capture microdissection assessment of virus compartmentalization in the central nervous systems of macaques infected with neurovirulent simian immunodeficiency virus.

Authors:  Kenta Matsuda; Charles R Brown; Brian Foley; Robert Goeken; Sonya Whitted; Que Dang; Fan Wu; Ronald Plishka; Alicia Buckler-White; Vanessa M Hirsch
Journal:  J Virol       Date:  2013-05-29       Impact factor: 5.103

8.  Modeling HIV-1 Induced Neuroinflammation in Mice: Role of Platelets in Mediating Blood-Brain Barrier Dysfunction.

Authors:  Letitia D Jones; Joseph W Jackson; Sanjay B Maggirwar
Journal:  PLoS One       Date:  2016-03-17       Impact factor: 3.240

9.  A SIV molecular clone that targets the CNS and induces neuroAIDS in rhesus macaques.

Authors:  Kenta Matsuda; Nadeene E Riddick; Cheri A Lee; Sarah B Puryear; Fan Wu; Bernard A P Lafont; Sonya Whitted; Vanessa M Hirsch
Journal:  PLoS Pathog       Date:  2017-08-07       Impact factor: 6.823

10.  Simian Immunodeficiency Virus-Infected Memory CD4+ T Cells Infiltrate to the Site of Infected Macrophages in the Neuroparenchyma of a Chronic Macaque Model of Neurological Complications of AIDS.

Authors:  Cheri A Lee; Erin Beasley; Karthikeyan Sundar; Margery Smelkinson; Carol Vinton; Claire Deleage; Kenta Matsuda; Fan Wu; Jake D Estes; Bernard A P Lafont; Jason M Brenchley; Vanessa M Hirsch
Journal:  mBio       Date:  2020-04-21       Impact factor: 7.867
  10 in total

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