Caroline Subra1,2, Lydie Trautmann3,4. 1. Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, MD, USA. 2. U.S. Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, MD, USA. 3. Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, MD, USA. ltrautmann@hivresearch.org. 4. U.S. Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, MD, USA. ltrautmann@hivresearch.org.
Abstract
PURPOSE OF REVIEW: The purpose of this review is to summarize the current knowledge on the role of CD4+ T lymphocytes leading to HIV assault and persistence in the central nervous system (CNS) and the elimination of HIV-infected CNS resident cells by CD8+ T lymphocytes. RECENT FINDINGS: HIV targets the CNS early in infection, and HIV-infected individuals suffer from mild forms of neurological impairments even under antiretroviral therapy (ART). CD4+ T cells and monocytes mediate HIV entry into the brain and constitute a source for HIV persistence and neuronal damage. HIV-specific CD8+ T cells are also massively recruited in the CNS in acute infection to control viral replication but cannot eliminate HIV-infected cells within the CNS. This review summarizes the involvement of CD4+ T cells in seeding and maintaining HIV infection in the brain and describes the involvement of CD8+ T cells in HIV neuropathogenesis, playing a role still to be deciphered, either beneficial in eliminating HIV-infected cells or deleterious in releasing inflammatory cytokines.
PURPOSE OF REVIEW: The purpose of this review is to summarize the current knowledge on the role of CD4+ T lymphocytes leading to HIV assault and persistence in the central nervous system (CNS) and the elimination of HIV-infected CNS resident cells by CD8+ T lymphocytes. RECENT FINDINGS: HIV targets the CNS early in infection, and HIV-infected individuals suffer from mild forms of neurological impairments even under antiretroviral therapy (ART). CD4+ T cells and monocytes mediate HIV entry into the brain and constitute a source for HIV persistence and neuronal damage. HIV-specific CD8+ T cells are also massively recruited in the CNS in acute infection to control viral replication but cannot eliminate HIV-infected cells within the CNS. This review summarizes the involvement of CD4+ T cells in seeding and maintaining HIV infection in the brain and describes the involvement of CD8+ T cells in HIV neuropathogenesis, playing a role still to be deciphered, either beneficial in eliminating HIV-infected cells or deleterious in releasing inflammatory cytokines.
Entities:
Keywords:
CNS HIV invasion; CNS inflammation; HIV neuropathogenesis; HIV-infected cell killing; T lymphocytes
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