Literature DB >> 29735563

Natamycin and Azithromycin Are Synergistic In Vitro against Ocular Pathogenic Aspergillus flavus Species Complex and Fusarium solani Species Complex Isolates.

Haoyi Guo1, Lutan Zhou2, Yi He1, Chuanwen Gao3, Lei Han1, Yan Xu4.   

Abstract

The interaction of natamycin-azithromycin combination against 60 ocular fungal isolates was tested in vitro The combination produced 100% synergistic interactions when natamycin was added to azithromycin 20, 40, and 50 μg/ml against Aspergillus flavus species complex (AFSC) isolates and to azithromycin 50 μg/ml against Fusarium solani species complex isolates. Addition of 50 μg/ml azithromycin enhanced natamycin's effect against AFSC isolates by reducing natamycin MIC90 from 64 to 0.031 μg/ml. No antagonism was observed.
Copyright © 2018 American Society for Microbiology.

Entities:  

Keywords:  Aspergillus flavus; Fusarium solani; azithromycin; fungal keratitis; natamycin; synergistic activity

Mesh：

Substances：

Year:  2018        PMID： 29735563      PMCID： PMC6021617          DOI： 10.1128/AAC.00077-18

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  22 in total

1.  Determination of natamycin in rabbit cornea by high-performance liquid chromatography-tandem mass spectrometry with protective soaking extraction technology.

Authors:  Zhou Tianyang; Zhu Ling; Xia Huiyun; He Jijun; Zhang Junjie
Journal:  J Chromatogr B Analyt Technol Biomed Life Sci       Date:  2014-08-12       Impact factor: 3.205

Review 2.  Combination treatment of invasive fungal infections.

Authors:  Pranab K Mukherjee; Daniel J Sheehan; Christopher A Hitchcock; Mahmoud A Ghannoum
Journal:  Clin Microbiol Rev       Date:  2005-01       Impact factor: 26.132

3.  Organism, minimum inhibitory concentration, and outcome in a fungal corneal ulcer clinical trial.

Authors:  Prajna Lalitha; N Venkatesh Prajna; Catherine E Oldenburg; Muthiah Srinivasan; Tiruvengada Krishnan; Jeena Mascarenhas; C M Vaitilingam; Stephen D McLeod; Michael E Zegans; Travis C Porco; Nisha R Acharya; Thomas M Lietman
Journal:  Cornea       Date:  2012-06       Impact factor: 2.651

4.  Epidemiology of Aspergillus keratitis at a tertiary care eye hospital in South India and antifungal susceptibilities of the causative agents.

Authors:  Palanisamy Manikandan; János Varga; Sándor Kocsubé; Raghavan Anita; Rajaraman Revathi; Tibor Mihály Németh; Venkatapathy Narendran; Csaba Vágvölgyi; Kanesan Panneer Selvam; Coimbatore Subramanian Shobana; Yendremban Randhir Babu Singh; László Kredics
Journal:  Mycoses       Date:  2012-04-10       Impact factor: 4.377

5.  Rifampin Enhances the Activity of Amphotericin B against Fusarium solani Species Complex and Aspergillus flavus Species Complex Isolates from Keratitis Patients.

Authors:  Yi He; Lutan Zhou; Chuanwen Gao; Lei Han; Yan Xu
Journal:  Antimicrob Agents Chemother       Date:  2017-03-24       Impact factor: 5.191

6.  Corneal pharmacokinetics of topically applied azithromycin and clarithromycin.

Authors:  Jonas J Kuehne; Anna Lisa T Yu; Gary N Holland; Anand Ramaswamy; Ryan Taban; Bartly J Mondino; Fei Yu; Sylvia A Rayner; Michael J Giese
Journal:  Am J Ophthalmol       Date:  2004-10       Impact factor: 5.258

7.  In vitro susceptibility of filamentous fungal isolates from a corneal ulcer clinical trial.

Authors:  Prajna Lalitha; Catherine Q Sun; N Venkatesh Prajna; Rajarathinam Karpagam; Manoharan Geetha; Kieran S O'Brien; Vicky Cevallos; Stephen D McLeod; Nisha R Acharya; Thomas M Lietman
Journal:  Am J Ophthalmol       Date:  2013-10-22       Impact factor: 5.258

Review 8.  Current perspectives on ophthalmic mycoses.

Authors:  Philip A Thomas
Journal:  Clin Microbiol Rev       Date:  2003-10       Impact factor: 26.132

9.  Fusarium keratitis: genotyping, in vitro susceptibility and clinical outcomes.

Authors:  Rafael A Oechsler; Michael R Feilmeier; Darlene Miller; Wei Shi; Ana Luisa Hofling-Lima; Eduardo C Alfonso
Journal:  Cornea       Date:  2013-05       Impact factor: 2.651

10.  Natamycin in the treatment of keratomycosis: correlation of treatment outcome and in vitro susceptibility of fungal isolates.

Authors:  Linu Pradhan; Savitri Sharma; Suma Nalamada; Srikant K Sahu; Sujata Das; Prashant Garg
Journal:  Indian J Ophthalmol       Date:  2011 Nov-Dec       Impact factor: 1.848
View more
  1 in total

1.  Natamycin and Voriconazole Exhibit Synergistic Interactions with Nonantifungal Ophthalmic Agents against Fusarium Species Ocular Isolates.

Authors:  Michael E Zegans; Robert A Cramer; Christiaan A Rees; Ruina Bao
Journal:  Antimicrob Agents Chemother       Date:  2019-06-24       Impact factor: 5.191
  1 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.