Literature DB >> 28115342

Rifampin Enhances the Activity of Amphotericin B against Fusarium solani Species Complex and Aspergillus flavus Species Complex Isolates from Keratitis Patients.

Yi He1, Lutan Zhou2, Chuanwen Gao3, Lei Han4, Yan Xu5.   

Abstract

The in vitro activities of amphotericin B in combination with rifampin were assessed against 95 ocular fungal isolates. The interactions between amphotericin B and rifampin at 4, 8, 16, and 32 μg/ml were synergistic for 11.8%, 51.0%, 90.2%, and 94.1%, respectively, of Fusarium solani species complex isolates and for 13.6%, 45.5%, 93.2%, and 95.5%, respectively, of Aspergillus flavus species complex isolates. Antagonism was never observed for the amphotericin B-rifampin combinations.
Copyright © 2017 American Society for Microbiology.

Entities:  

Keywords:  Aspergillus flavus species complex; Fusarium solani species complex; amphotericin B; fungal keratitis; rifampin; synergistic activity

Mesh：

Substances：

Year:  2017        PMID： 28115342      PMCID： PMC5365659          DOI： 10.1128/AAC.02069-16

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  31 in total

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8.  Bioavailability and penetration of topical amphotericin B in the anterior segment of the rabbit eye.

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9.  International Evaluation of MIC Distributions and Epidemiological Cutoff Value (ECV) Definitions for Fusarium Species Identified by Molecular Methods for the CLSI Broth Microdilution Method.

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1.  Natamycin and Azithromycin Are Synergistic In Vitro against Ocular Pathogenic Aspergillus flavus Species Complex and Fusarium solani Species Complex Isolates.

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4.  Infection of Fungi and Bacteria in Brain Tissue From Elderly Persons and Patients With Alzheimer's Disease.

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Review 5.  Fusarium Keratitis-Review of Current Treatment Possibilities.

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