| Literature DB >> 29729972 |
Elisabeth M van Leeuwen1, Eszter Emri2, Benedicte M J Merle3, Johanna M Colijn1, Eveline Kersten4, Audrey Cougnard-Gregoire3, Sascha Dammeier5, Magda Meester-Smoor1, Frances M Pool6, Eiko K de Jong4, Cécile Delcourt3, Eduardo Rodrigez-Bocanegra7, Marc Biarnés7, Philip J Luthert6, Marius Ueffing5, Caroline C W Klaver8, Everson Nogoceke9, Anneke I den Hollander10, Imre Lengyel11.
Abstract
There is an urgency to find new treatment strategies that could prevent or delay the onset or progression of AMD. Different classes of lipids and lipoproteins metabolism genes have been associated with AMD in a multiple ways, but despite the ever-increasing knowledge base, we still do not understand fully how circulating lipids or local lipid metabolism contribute to AMD. It is essential to clarify whether dietary lipids, systemic or local lipoprotein metabolismtrafficking of lipids in the retina should be targeted in the disease. In this article, we critically evaluate what has been reported in the literature and identify new directions needed to bring about a significant advance in our understanding of the role for lipids in AMD. This may help to develop potential new treatment strategies through targeting the lipid homeostasis.Entities:
Keywords: Age-related macular degeneration (AMD); Circulating lipoproteins; Dietary lipids; Genetics; High-density lipoprotein cholesterol (HDL-C); Retinal lipids
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Year: 2018 PMID： 29729972 DOI： 10.1016/j.preteyeres.2018.04.006
Source DB: PubMed Journal: Prog Retin Eye Res ISSN： 1350-9462 Impact factor: 21.198