Literature DB >> 31884586

Long-Chain Polyunsaturated Fatty Acids and Age-Related Macular Degeneration.

Dorota Skowronska-Krawczyk1, Daniel L Chao2.   

Abstract

Age-related macular degeneration (AMD) is one of the leading causes of blindness worldwide. Long-chain and very long-chain polyunsaturated fatty acids (LC and VLC-PUFAs) have been linked to AMD pathogenesis through epidemiologic, biochemical, and genetic studies; however, the exact mechanisms of pathogenesis are unknown. Here, we review the scientific and clinical evidence supporting the role of PUFAs in AMD and discuss future directions for elucidating the roles of these fatty acids in AMD pathogenesis.

Entities:  

Keywords:  Age-related macular degeneration (AMD); Elongation of very long-chain fatty acids; Lipids in the retina biology; Long-chain polyunsaturated fatty acids (LC-PUFA); PUFA in clinical trials for AMD

Mesh：

Substances：

Year:  2019        PMID： 31884586      PMCID： PMC7526619          DOI： 10.1007/978-3-030-27378-1_7

Source DB:  PubMed          Journal:  Adv Exp Med Biol        ISSN： 0065-2598            Impact factor:   2.622


  22 in total

1.  Long-chain and very long-chain polyunsaturated fatty acids in ocular aging and age-related macular degeneration.

Authors:  Aihua Liu; James Chang; Yanhua Lin; Zhengqing Shen; Paul S Bernstein
Journal:  J Lipid Res       Date:  2010-08-05       Impact factor: 5.922

2.  Docosahexaenoic acid signalolipidomics in nutrition: significance in aging, neuroinflammation, macular degeneration, Alzheimer's, and other neurodegenerative diseases.

Authors:  Nicolas G Bazan; Miguel F Molina; William C Gordon
Journal:  Annu Rev Nutr       Date:  2011-08-21       Impact factor: 11.848

3.  Dietary ω-3 fatty acid and fish intake and incident age-related macular degeneration in women.

Authors:  William G Christen; Debra A Schaumberg; Robert J Glynn; Julie E Buring
Journal:  Arch Ophthalmol       Date:  2011-03-14

4.  A 5-bp deletion in ELOVL4 is associated with two related forms of autosomal dominant macular dystrophy.

Authors:  K Zhang; M Kniazeva; M Han; W Li; Z Yu; Z Yang; Y Li; M L Metzker; R Allikmets; D J Zack; L E Kakuk; P S Lagali; P W Wong; I M MacDonald; P A Sieving; D J Figueroa; C P Austin; R J Gould; R Ayyagari; K Petrukhin
Journal:  Nat Genet       Date:  2001-01       Impact factor: 38.330

5.  Essential role of ELOVL4 protein in very long chain fatty acid synthesis and retinal function.

Authors:  Richard Harkewicz; Hongjun Du; Zongzhong Tong; Hisham Alkuraya; Matthew Bedell; Woong Sun; Xiaolei Wang; Yuan-Hao Hsu; Julian Esteve-Rudd; Guy Hughes; Zhiguang Su; Ming Zhang; Vanda S Lopes; Robert S Molday; David S Williams; Edward A Dennis; Kang Zhang
Journal:  J Biol Chem       Date:  2011-12-24       Impact factor: 5.157

6.  A novel gene for autosomal dominant Stargardt-like macular dystrophy with homology to the SUR4 protein family.

Authors:  A O Edwards; L A Donoso; R Ritter
Journal:  Invest Ophthalmol Vis Sci       Date:  2001-10       Impact factor: 4.799

7.  The Age-Related Eye Disease Study 2 (AREDS2): study design and baseline characteristics (AREDS2 report number 1).

Authors:  Emily Y Chew; Traci Clemons; John Paul SanGiovanni; Ronald Danis; Amitha Domalpally; Wendy McBee; Robert Sperduto; Frederick L Ferris
Journal:  Ophthalmology       Date:  2012-07-26       Impact factor: 12.079

8.  Human aging and disease: Lessons from age-related macular degeneration.

Authors:  Jennings Luu; Krzysztof Palczewski
Journal:  Proc Natl Acad Sci U S A       Date:  2018-02-26       Impact factor: 11.205

Review 9.  Docosanoids and elovanoids from omega-3 fatty acids are pro-homeostatic modulators of inflammatory responses, cell damage and neuroprotection.

Authors:  Nicolas G Bazan
Journal:  Mol Aspects Med       Date:  2018-10-01

10.  Genetic loci associated with plasma phospholipid n-3 fatty acids: a meta-analysis of genome-wide association studies from the CHARGE Consortium.

Authors:  Rozenn N Lemaitre; Toshiko Tanaka; Weihong Tang; Ani Manichaikul; Millennia Foy; Edmond K Kabagambe; Jennifer A Nettleton; Irena B King; Lu-Chen Weng; Sayanti Bhattacharya; Stefania Bandinelli; Joshua C Bis; Stephen S Rich; David R Jacobs; Antonio Cherubini; Barbara McKnight; Shuang Liang; Xiangjun Gu; Kenneth Rice; Cathy C Laurie; Thomas Lumley; Brian L Browning; Bruce M Psaty; Yii-Der I Chen; Yechiel Friedlander; Luc Djousse; Jason H Y Wu; David S Siscovick; André G Uitterlinden; Donna K Arnett; Luigi Ferrucci; Myriam Fornage; Michael Y Tsai; Dariush Mozaffarian; Lyn M Steffen
Journal:  PLoS Genet       Date:  2011-07-28       Impact factor: 5.917
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  4 in total

1.  Tissue fixation effects on human retinal lipid analysis by MALDI imaging and LC-MS/MS technologies.

Authors:  Ankita Kotnala; David M G Anderson; Nathan Heath Patterson; Lee S Cantrell; Jeffrey D Messinger; Christine A Curcio; Kevin L Schey
Journal:  J Mass Spectrom       Date:  2021-12       Impact factor: 2.394

2.  Elovl2 Is Required for Robust Visual Function in Zebrafish.

Authors:  Manish Dasyani; Fangyuan Gao; Qianlan Xu; Donald Van Fossan; Ellis Zhang; Antonio F M Pinto; Alan Saghatelian; Dorota Skowronska-Krawczyk; Daniel L Chao
Journal:  Cells       Date:  2020-12-02       Impact factor: 6.600

Review 3.  The Aging Stress Response and Its Implication for AMD Pathogenesis.

Authors:  Janusz Blasiak; Elzbieta Pawlowska; Anna Sobczuk; Joanna Szczepanska; Kai Kaarniranta
Journal:  Int J Mol Sci       Date:  2020-11-22       Impact factor: 5.923

Review 4.  Long-Chain Polyunsaturated Fatty Acids and Their Metabolites Regulate Inflammation in Age-Related Macular Degeneration.

Authors:  Jiangbo Ren; Anli Ren; Xizhi Deng; Zhengrong Huang; Ziyu Jiang; Zhi Li; Yan Gong
Journal:  J Inflamm Res       Date:  2022-02-09
  4 in total

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