Literature DB >> 29724526

Vitamin C in Stem Cell Reprogramming and Cancer.

Luisa Cimmino1, Benjamin G Neel2, Iannis Aifantis3.   

Abstract

Vitamin C is an essential dietary requirement for humans. In addition to its known role as an antioxidant, vitamin C is a cofactor for Fe2+- and α-ketoglutarate-dependent dioxygenases (Fe2+/α-KGDDs) which comprise a large number of diverse enzymes, including collagen prolyl hydroxylases and epigenetic regulators of histone and DNA methylation. Vitamin C can modulate embryonic stem cell (ESC) function, enhance reprogramming of fibroblasts to induced pluripotent stem cells (iPSCs), and hinder the aberrant self-renewal of hematopoietic stem cells (HSCs) through its ability to enhance the activity of either Jumonji C (JmjC) domain-containing histone demethylases or ten-eleven translocation (TET) DNA hydroxylases. Given that epigenetic dysregulation is a known driver of malignancy, vitamin C may play a novel role as an epigenetic anticancer agent.
Copyright © 2018. Published by Elsevier Ltd.

Entities:  

Keywords:  TET proteins; cancer; epigenetics; methylation; stem cells; vitamin C

Mesh：

Substances：

Year:  2018        PMID： 29724526      PMCID： PMC6102081          DOI： 10.1016/j.tcb.2018.04.001

Source DB:  PubMed          Journal:  Trends Cell Biol        ISSN： 0962-8924            Impact factor:   20.808


  78 in total

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Journal:  Nat Rev Genet       Date:  2006-09       Impact factor: 53.242

2.  H3K9 methylation is a barrier during somatic cell reprogramming into iPSCs.

Authors:  Jiekai Chen; He Liu; Jing Liu; Jing Qi; Bei Wei; Jiaqi Yang; Hanquan Liang; You Chen; Jing Chen; Yaran Wu; Lin Guo; Jieying Zhu; Xiangjie Zhao; Tianran Peng; Yixin Zhang; Shen Chen; Xuejia Li; Dongwei Li; Tao Wang; Duanqing Pei
Journal:  Nat Genet       Date:  2012-12-02       Impact factor: 38.330

3.  Vitamin C increases viral mimicry induced by 5-aza-2'-deoxycytidine.

Authors:  Minmin Liu; Hitoshi Ohtani; Wanding Zhou; Andreas Due Ørskov; Jessica Charlet; Yang W Zhang; Hui Shen; Stephen B Baylin; Gangning Liang; Kirsten Grønbæk; Peter A Jones
Journal:  Proc Natl Acad Sci U S A       Date:  2016-08-29       Impact factor: 11.205

4.  Early-stage epigenetic modification during somatic cell reprogramming by Parp1 and Tet2.

Authors:  Claudia A Doege; Keiichi Inoue; Toru Yamashita; David B Rhee; Skylar Travis; Ryousuke Fujita; Paolo Guarnieri; Govind Bhagat; William B Vanti; Alan Shih; Ross L Levine; Sara Nik; Emily I Chen; Asa Abeliovich
Journal:  Nature       Date:  2012-08-30       Impact factor: 49.962

5.  FIH-1 is an asparaginyl hydroxylase enzyme that regulates the transcriptional activity of hypoxia-inducible factor.

Authors:  David Lando; Daniel J Peet; Jeffrey J Gorman; Dean A Whelan; Murray L Whitelaw; Richard K Bruick
Journal:  Genes Dev       Date:  2002-06-15       Impact factor: 11.361

Review 6.  Structural studies on 2-oxoglutarate oxygenases and related double-stranded beta-helix fold proteins.

Authors:  Ian J Clifton; Michael A McDonough; Dominic Ehrismann; Nadia J Kershaw; Nicolas Granatino; Christopher J Schofield
Journal:  J Inorg Biochem       Date:  2006-03-02       Impact factor: 4.155

7.  Ascorbic acid serum levels are reduced in patients with hematological malignancies.

Authors:  Mirelle J A J Huijskens; Will K W H Wodzig; Mateusz Walczak; Wilfred T V Germeraad; Gerard M J Bos
Journal:  Results Immunol       Date:  2016-01-12

8.  High-dose ascorbate and arsenic trioxide selectively kill acute myeloid leukemia and acute promyelocytic leukemia blasts in vitro.

Authors:  Nélida I Noguera; Elvira Pelosi; Daniela F Angelini; Maria Liliana Piredda; Gisella Guerrera; Eleonora Piras; Luca Battistini; Lauretta Massai; Anna Berardi; Gianfranco Catalano; Laura Cicconi; Germana Castelli; Agnese D'Angiò; Luca Pasquini; Grazia Graziani; Giuseppe Fioritoni; Maria Teresa Voso; Domenico Mastrangelo; Ugo Testa; Francesco Lo-Coco
Journal:  Oncotarget       Date:  2017-05-16

9.  Variation in FTO contributes to childhood obesity and severe adult obesity.

Authors:  Christian Dina; David Meyre; Sophie Gallina; Emmanuelle Durand; Antje Körner; Peter Jacobson; Lena M S Carlsson; Wieland Kiess; Vincent Vatin; Cecile Lecoeur; Jérome Delplanque; Emmanuel Vaillant; François Pattou; Juan Ruiz; Jacques Weill; Claire Levy-Marchal; Fritz Horber; Natascha Potoczna; Serge Hercberg; Catherine Le Stunff; Pierre Bougnères; Peter Kovacs; Michel Marre; Beverley Balkau; Stéphane Cauchi; Jean-Claude Chèvre; Philippe Froguel
Journal:  Nat Genet       Date:  2007-05-13       Impact factor: 38.330

10.  Vitamin C induces Tet-dependent DNA demethylation and a blastocyst-like state in ES cells.

Authors:  Kathryn Blaschke; Kevin T Ebata; Mohammad M Karimi; Jorge A Zepeda-Martínez; Preeti Goyal; Sahasransu Mahapatra; Angela Tam; Diana J Laird; Martin Hirst; Anjana Rao; Matthew C Lorincz; Miguel Ramalho-Santos
Journal:  Nature       Date:  2013-06-30       Impact factor: 49.962
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  50 in total

Review 1.  Metabolic Regulation of Tissue Stem Cells.

Authors:  Suzanne N Shapira; Heather R Christofk
Journal:  Trends Cell Biol       Date:  2020-04-28       Impact factor: 20.808

Review 2.  The small members of the JMJD protein family: Enzymatic jewels or jinxes?

Authors:  Sangphil Oh; Sook Shin; Ralf Janknecht
Journal:  Biochim Biophys Acta Rev Cancer       Date:  2019-04-26       Impact factor: 10.680

3.  Dual TGFβ/BMP Pathway Inhibition Enables Expansion and Characterization of Multiple Epithelial Cell Types of the Normal and Cancerous Breast.

Authors:  Mayuri Prasad; Brijesh Kumar; Poornima Bhat-Nakshatri; Manjushree Anjanappa; George Sandusky; Kathy D Miller; Anna Maria Storniolo; Harikrishna Nakshatri
Journal:  Mol Cancer Res       Date:  2019-04-16       Impact factor: 5.852

4.  Ascorbic acid and all-trans retinoic acid promote proliferation of chicken blastoderm cells (cBCs) by mediating DNA demethylation.

Authors:  Yinglin Lu; Haobin Wang; Heng Cao; Xiaolu Chen; Dongfeng Li; Debing Yu; Minli Yu
Journal:  In Vitro Cell Dev Biol Anim       Date:  2022-03-14       Impact factor: 2.416

5.  High-dose VitC plus oncolytic adenoviruses enhance immunogenic tumor cell death and reprogram tumor immune microenvironment.

Authors:  Jinhu Ma; Chunxue Zhang; Gang Shi; Dan Yue; Yongheng Shu; Shichuan Hu; Zhongbing Qi; Yanwei Chen; Bin Zhang; Yong Zhang; Anliang Huang; Chao Su; Yan Zhang; Hongxin Deng; Ping Cheng
Journal:  Mol Ther       Date:  2021-09-20       Impact factor: 11.454

Review 6.  Epigenetic dynamics in cancer stem cell dormancy.

Authors:  Alejandra I Ferrer; Jonathan R Trinidad; Oleta Sandiford; Jean-Pierre Etchegaray; Pranela Rameshwar
Journal:  Cancer Metastasis Rev       Date:  2020-09       Impact factor: 9.264

Review 7.  A guide to plasma membrane solute carrier proteins.

Authors:  Mattia D Pizzagalli; Ariel Bensimon; Giulio Superti-Furga
Journal:  FEBS J       Date:  2020-09-18       Impact factor: 5.542

Review 8.  Metabolic signatures of cancer cells and stem cells.

Authors:  Andrew M Intlekofer; Lydia W S Finley
Journal:  Nat Metab       Date:  2019-02-11

Review 9.  Deciphering the multifaceted roles of TET proteins in T-cell lineage specification and malignant transformation.

Authors:  Ageliki Tsagaratou
Journal:  Immunol Rev       Date:  2021-01-07       Impact factor: 12.988

10.  Global epigenetic alterations of mesenchymal stem cells in obesity: the role of vitamin C reprogramming.

Authors:  Mohsen Afarideh; Roman Thaler; Farzaneh Khani; Hui Tang; Kyra L Jordan; Sabena M Conley; Ishran M Saadiq; Yasin Obeidat; Aditya S Pawar; Alfonso Eirin; Xiang-Yang Zhu; Amir Lerman; Andre J van Wijnen; Lilach O Lerman
Journal:  Epigenetics       Date:  2020-09-20       Impact factor: 4.528
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