Literature DB >> 29722785

Improved enzyme annotation with EC-specific cutoffs using DETECT v2.

Nirvana Nursimulu1,2, Leon L Xu1, James D Wasmuth3, Ivan Krukov3, John Parkinson1,4,5.   

Abstract

Summary: We present DETECT v2-an enzyme annotation tool which considers the effect of sequence diversity when assigning enzymatic function [as an Enzyme Commission (EC) number] to a protein sequence. In addition to capturing more enzyme classes than the previous version, we now provide EC-specific cutoffs that greatly increase precision and recall of assignments and show its performance in the context of pathways. Availability and implementation: https://github.com/ParkinsonLab/DETECT-v2. Supplementary information: Supplementary data are available at Bioinformatics online.

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Year:  2018        PMID： 29722785      PMCID： PMC6157075          DOI： 10.1093/bioinformatics/bty368

Source DB:  PubMed          Journal:  Bioinformatics        ISSN： 1367-4803            Impact factor:   6.937


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