Xuhong Hou1,2,3,4, Peizhu Chen1,2,3,5, Gang Hu4, Li Wei1,2,3,5, Lei Jiao6, Hongmei Wang6, Yebei Liang1,2,3,5, Yuqian Bao1,2,3,5, Weiping Jia1,2,3,5. 1. Department of Endocrinology and Metabolism, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, China. 2. Shanghai Diabetes Institute, Shanghai, China. 3. Shanghai Clinical Center for Diabetes, Shanghai, China. 4. Pennington Biomedical Research Center, Baton Rouge, Louisiana, USA. 5. Shanghai Key Clinical Center for Metabolic Disease, Shanghai, China. 6. Department of Radiology, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, China.
Abstract
OBJECTIVE: The objective of this study was to assess the associations of abdominal visceral and subcutaneous adipose tissue with blood glucose and beta-cell function. METHODS: In this study, 11,223 participants without known diabetes were selected for this cross-sectional analysis. Visceral and subcutaneous fat area (VFA and SFA) were measured by magnetic resonance imaging. An oral glucose tolerance test was conducted, and beta-cell function was evaluated. RESULTS: Men had significantly larger VFA but smaller SFA than women. After controlling for age, linear regression showed that SFA was adversely associated with 0-minute, 30-minute, and 2-hour plasma glucose (PG) and early-, first- and second-phase disposition indices (DIs). After further adjustment for BMI and VFA, some associations of SFA with PG indices and DIs disappeared, while the other associations became significantly weaker in men (2-hour PG: 0.05 and DI2nd : -0.05) or were reversed in women (0-minute, 30-minute, and 2-hour PG: from -0.07 to -0.04; DI1st : 0.04, P < 0.05). After adjustment for age, BMI, and SFA, VFA was significantly and adversely associated with PG indices and DIs, with the largest standardized regression coefficients with 2-hour PG. CONCLUSIONS: The associations of SFA with blood glucose and beta-cell function were clinically insignificant in Chinese adults. VFA had the strongest association with 2-hour PG.
OBJECTIVE: The objective of this study was to assess the associations of abdominal visceral and subcutaneous adipose tissue with blood glucose and beta-cell function. METHODS: In this study, 11,223 participants without known diabetes were selected for this cross-sectional analysis. Visceral and subcutaneous fat area (VFA and SFA) were measured by magnetic resonance imaging. An oral glucose tolerance test was conducted, and beta-cell function was evaluated. RESULTS: Men had significantly larger VFA but smaller SFA than women. After controlling for age, linear regression showed that SFA was adversely associated with 0-minute, 30-minute, and 2-hour plasma glucose (PG) and early-, first- and second-phase disposition indices (DIs). After further adjustment for BMI and VFA, some associations of SFA with PG indices and DIs disappeared, while the other associations became significantly weaker in men (2-hour PG: 0.05 and DI2nd : -0.05) or were reversed in women (0-minute, 30-minute, and 2-hour PG: from -0.07 to -0.04; DI1st : 0.04, P < 0.05). After adjustment for age, BMI, and SFA, VFA was significantly and adversely associated with PG indices and DIs, with the largest standardized regression coefficients with 2-hour PG. CONCLUSIONS: The associations of SFA with blood glucose and beta-cell function were clinically insignificant in Chinese adults. VFA had the strongest association with 2-hour PG.
Authors: M Brochu; R D Starling; A Tchernof; D E Matthews; E Garcia-Rubi; E T Poehlman Journal: J Clin Endocrinol Metab Date: 2000-07 Impact factor: 5.958
Authors: Tamara S Hannon; Steven E Kahn; Kristina M Utzschneider; Thomas A Buchanan; Kristen J Nadeau; Philip S Zeitler; David A Ehrmann; Silva A Arslanian; Sonia Caprio; Sharon L Edelstein; Peter J Savage; Kieren J Mather Journal: Diabetes Obes Metab Date: 2017-06-22 Impact factor: 6.577
Authors: Robert Ross; James Aru; Jennifer Freeman; Robert Hudson; Ian Janssen Journal: Am J Physiol Endocrinol Metab Date: 2002-03 Impact factor: 4.310
Authors: Caroline S Fox; Joseph M Massaro; Udo Hoffmann; Karla M Pou; Pal Maurovich-Horvat; Chun-Yu Liu; Ramachandran S Vasan; Joanne M Murabito; James B Meigs; L Adrienne Cupples; Ralph B D'Agostino; Christopher J O'Donnell Journal: Circulation Date: 2007-06-18 Impact factor: 29.690
Authors: Annelotte Philipsen; Marit E Jørgensen; Dorte Vistisen; Annelli Sandbaek; Thomas P Almdal; Jens S Christiansen; Torsten Lauritzen; Daniel R Witte Journal: PLoS One Date: 2015-04-07 Impact factor: 3.240