Literature DB >> 29711251

Chemical Synthesis of a Circular Protein Domain: Evidence for Folding-Assisted Cyclization.

Julio A Camarero1, Joanna Pavel1, Tom W Muir1.   

Abstract

Extremely fast cyclization of the linear polypeptide precursor 1 takes place to form 2. The reaction appears to be assisted by the native fold of 1, which positions the reactive ends in close proximity. The circular topology has no influence on the folding or function of 2. © 1998 WILEY-VCH Verlag GmbH, Weinheim, Fed. Rep. of Germany.

Keywords:  Cyclizations; Peptides; Protein structures; Solid-phase synthesis

Year:  1998        PMID： 29711251     DOI： 10.1002/(SICI)1521-3773(19980216)37:3<347::AID-ANIE347>3.0.CO;2-5

Source DB:  PubMed          Journal:  Angew Chem Int Ed Engl        ISSN： 1433-7851            Impact factor:   15.336


  10 in total

Review 1.  Biological synthesis of circular polypeptides.

Authors:  Teshome L Aboye; Julio A Camarero
Journal:  J Biol Chem       Date:  2012-06-14       Impact factor: 5.157

2.  A straight path to circular proteins.

Authors:  John M Antos; Maximilian Wei-Lin Popp; Robert Ernst; Guo-Liang Chew; Eric Spooner; Hidde L Ploegh
Journal:  J Biol Chem       Date:  2009-04-09       Impact factor: 5.157

3.  Circular permutation of a WW domain: folding still occurs after excising the turn of the folding-nucleating hairpin.

Authors:  Brandon L Kier; Jordan M Anderson; Niels H Andersen
Journal:  J Am Chem Soc       Date:  2014-01-03       Impact factor: 15.419

4.  Backbone dynamics of cyclotide MCoTI-I free and complexed with trypsin.

Authors:  Shadakshara S Puttamadappa; Krishnappa Jagadish; Alexander Shekhtman; Julio A Camarero
Journal:  Angew Chem Int Ed Engl       Date:  2010-09-17       Impact factor: 15.336

5.  Chemical Synthesis of a Potent Antimicrobial Peptide Murepavadin Using a Tandem Native Chemical Ligation/Desulfurization Reaction.

Authors:  Dipankar Chaudhuri; Rajasekaran Ganesan; Alicia Vogelaar; Mansour A Dughbaj; Paul M Beringer; Julio A Camarero
Journal:  J Org Chem       Date:  2021-10-12       Impact factor: 4.354

6.  Solid-phase synthesis of peptidyl thioacids employing a 9-fluorenylmethyl thioester-based linker in conjunction with Boc chemistry.

Authors:  David Crich; Kasinath Sana
Journal:  J Org Chem       Date:  2009-10-02       Impact factor: 4.354

7.  Thermal stabilization of an endoglucanase by cyclization.

Authors:  Johan F T van Lieshout; Odette N Pérez Gutiérrez; Wietse Vroom; Antoni Planas; Willem M de Vos; John van der Oost; Sotirios Koutsopoulos
Journal:  Appl Biochem Biotechnol       Date:  2012-06-01       Impact factor: 2.926

8.  Chemical synthesis of a homoserine-mutant of the antibacterial, head-to-tail cyclized protein AS-48 by α-ketoacid-hydroxylamine (KAHA) ligation.

Authors:  Florian Rohrbacher; André Zwicky; Jeffrey W Bode
Journal:  Chem Sci       Date:  2017-04-24       Impact factor: 9.825

9.  Accelerating chemoselective peptide bond formation using bis(2-selenylethyl)amido peptide selenoester surrogates.

Authors:  Laurent Raibaut; Marine Cargoët; Nathalie Ollivier; Yun Min Chang; Hervé Drobecq; Emmanuelle Boll; Rémi Desmet; Jean-Christophe M Monbaliu; Oleg Melnyk
Journal:  Chem Sci       Date:  2016-01-11       Impact factor: 9.825

Review 10.  Chemical synthesis, backbone cyclization and oxidative folding of cystine-knot peptides: promising scaffolds for applications in drug design.

Authors:  Michael Reinwarth; Daichi Nasu; Harald Kolmar; Olga Avrutina
Journal:  Molecules       Date:  2012-10-24       Impact factor: 4.411
  10 in total

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