Ilaria Campesi1,2, Maria Marino3, Manuela Cipolletti3, Annalisa Romani4, Flavia Franconi5,6,7. 1. Department of Biomedical Sciences, Via Muroni 23, University of Sassari, Sassari, Italy. icampesi@uniss.it. 2. Laboratory of Sex-Gender Medicine, National Institute of Biostructures and Biosystems, Sassari, Italy. icampesi@uniss.it. 3. Department of Science, University Roma Tre, Rome, Italy. 4. Laboratorio PHYTOLAB (Pharmaceutical, Cosmetic, Food Supplement Technology and Analysis), University of Florence, Sesto F.no, Firenze, Italy. 5. Department of Biomedical Sciences, Via Muroni 23, University of Sassari, Sassari, Italy. 6. Laboratory of Sex-Gender Medicine, National Institute of Biostructures and Biosystems, Sassari, Italy. 7. Assessorato alle Politiche per la Persona of Basilicata Region, Potenza, Italy.
Abstract
INTRODUCTION: The influence of sex and gender is particularly relevant in cardiovascular diseases (CVD) as well as in several aspects of drug pharmacodynamics and pharmacokinetics. Anatomical and physiological differences between the sexes may influence the activity of many drugs, including the possibility of their interaction with other drugs, bioactive compounds, foods and beverages. Phenolic compounds could interact with our organism at organ, cellular, and molecular levels triggering a preventive action against chronic diseases, including CVD. RESULTS: This article will review the role of sex on the activity of these bioactive molecules, considering the existence of sex differences in oxidative stress. It describes the pharmacokinetics of phenolic compounds, their effects on vessels, on cardiovascular system, and during development, including the role of nuclear receptors and microbiota. CONCLUSIONS: Although there is a large gap between the knowledge of the sex differences in the phenolic compounds' activity and safety, and the urgent need for more research, available data underlie the possibility that plant-derived phenolic compounds could differently influence the health of male and female subjects.
INTRODUCTION: The influence of sex and gender is particularly relevant in cardiovascular diseases (CVD) as well as in several aspects of drug pharmacodynamics and pharmacokinetics. Anatomical and physiological differences between the sexes may influence the activity of many drugs, including the possibility of their interaction with other drugs, bioactive compounds, foods and beverages. Phenolic compounds could interact with our organism at organ, cellular, and molecular levels triggering a preventive action against chronic diseases, including CVD. RESULTS: This article will review the role of sex on the activity of these bioactive molecules, considering the existence of sex differences in oxidative stress. It describes the pharmacokinetics of phenolic compounds, their effects on vessels, on cardiovascular system, and during development, including the role of nuclear receptors and microbiota. CONCLUSIONS: Although there is a large gap between the knowledge of the sex differences in the phenolic compounds' activity and safety, and the urgent need for more research, available data underlie the possibility that plant-derived phenolic compounds could differently influence the health of male and female subjects.
Authors: Rebecca H Ritchie; Grant R Drummond; Christopher G Sobey; T Michael De Silva; Barbara K Kemp-Harper Journal: Pharmacol Res Date: 2016-12-15 Impact factor: 7.658
Authors: Emily P Laveriano-Santos; María Marhuenda-Muñoz; Anna Vallverdú-Queralt; Miriam Martínez-Huélamo; Anna Tresserra-Rimbau; Elefterios Miliarakis; Camila Arancibia-Riveros; Olga Jáuregui; Ana María Ruiz-León; Sara Castro-Baquero; Ramón Estruch; Patricia Bodega; Mercedes de Miguel; Amaya de Cos-Gandoy; Jesús Martínez-Gómez; Gloria Santos-Beneit; Juan M Fernández-Alvira; Rodrigo Fernández-Jiménez; Rosa M Lamuela-Raventós Journal: Antioxidants (Basel) Date: 2022-06-14