| Literature DB >> 29691774 |
Sang-Hoon Han1, Byung-Joo Park1, Hee-Seop Ahn1, Yong-Hyun Kim1, Hyeon-Jeong Go1, Dong-Hwi Kim1, Joong-Bok Lee1, Seung-Yong Park1, Chang-Seon Song1, Sang-Won Lee1, In-Soo Choi2.
Abstract
Rabbits are considered a new natural reservoir of hepatitis E virus (HEV). In this study, HEV infection was verified by the detection of partial genomic sequence of HEV and anti-HEV antibodies in specific pathogen-free (SPF) rabbits. HEV RNA was found in 6.4% serum and 13.5% fecal samples from 126 SPF rabbits. Anti-HEV antibodies were also detected in 4.0% of the SPF rabbits. HEV genetic sequences isolated from the rabbits were clustered into a rabbit HEV clade with other rabbit HEV isolates; they were found to be most closely related with a rabbit HEV sequence previously reported in Korea. Therefore, HEV infection should be diagnosed before conducting experiments involving SPF rabbits.Entities:
Keywords: Antibody; Hepatitis E virus; RNA; Specific pathogen-free rabbit
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Year: 2018 PMID： 29691774 DOI： 10.1007/s11262-018-1562-3
Source DB: PubMed Journal: Virus Genes ISSN： 0920-8569 Impact factor: 2.332