| Literature DB >> 28284626 |
Baoyuan Liu1, Yani Sun1, Taofeng Du1, Yiyang Chen1, Xinjie Wang1, Baicheng Huang1, Huixia Li1, Yuchen Nan1, Shuqi Xiao1, Gaiping Zhang2, Julian A Hiscox3, En-Min Zhou4, Qin Zhao5.
Abstract
Hepatitis E virus (HEV) has been detected in rabbits, a recently identified natural reservoir. In this study, anti-HEV antibodies and viral RNA were detected in rabbits sourced from a specific-pathogen-free (SPF) rabbit vendor in Shaanxi Province, China. BLAST results of partial HEV ORF2 genes cloned here indicated that two viral strains circulated in the rabbits. Sequence determination of the complete genome (7302bp) of one strain and a partial ORF1 gene (1537bp) of the other strain showed that they shared 90% identity with one another and 78%-94% identity with other known rabbit HEVs. In addition, inoculation with rabbit HEV from SPF rabbits studied here resulted in infection of SPF pigs; this cross-species transmission was evidenced by seroconversion, viremia and faecal virus shedding. These results suggest that to prevent spread of this zoonotic pathogen, rabbits should be tested routinely for HEV RNA in SPF vendor facilities.Entities:
Keywords: Cross-species; HEV; Hepatitis E virus; Rabbit; Zoonosis
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Year: 2017 PMID： 28284626 DOI： 10.1016/j.vetmic.2016.10.029
Source DB: PubMed Journal: Vet Microbiol ISSN： 0378-1135 Impact factor: 3.293