| Literature DB >> 26551551 |
Guan-Huei Lee1, Boon-Huan Tan2, Esmeralda Chi-Yuan Teo3, Seng-Gee Lim4, Yock-Young Dan4, Aileen Wee5, Pauline Poh Kim Aw6, Yuan Zhu6, Martin Lloyd Hibberd7, Chee-Kiat Tan8, Michael A Purdy9, Chong-Gee Teo9.
Abstract
There have been increasing reports of food-borne zoonotic transmission of hepatitis E virus (HEV) genotype 3, which causes chronic infections in immunosuppressed patients. We performed phylogenetic analyses of the HEV sequence (partial and full-length) from 1 patient from the Middle East who underwent liver transplantation, and compared it with other orthohepevirus A sequences. We found the patient to be infected by camelid HEV. This patient regularly consumed camel meat and milk, therefore camelid HEV, which is genotype 7, might infect human beings. Our finding links consumption of camel-derived food products to post-transplantation hepatitis E, which, if detected at early stages, can be cured with antiviral therapy and reduced administration of immunosuppressive agents.Entities:
Keywords: Case Study; Liver Disease; Viral Infection; Zoonosis
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Year: 2015 PMID: 26551551 DOI: 10.1053/j.gastro.2015.10.048
Source DB: PubMed Journal: Gastroenterology ISSN: 0016-5085 Impact factor: 22.682