Rebeca Reyes-Garcia1,2, Nicolas Mendoza3, Santiago Palacios4, Nancy Salas4, Miguel Quesada-Charneco1, Antonia Garcia-Martin1, Juristo Fonolla5, Federico Lara-Villoslada6, Manuel Muñoz-Torres1. 1. 1 Bone Metabolic Unit (CIBERFES), UGC Endocrinología y Nutrición, Hospital Universitario San Cecilio, Instituto de Investigación Biosanitario de Granada (Ibs. Granada) , Granada, Spain . 2. 2 Unidad de Endocrinología y Nutrición, Complejo Hospitalario Torrecardenas , Almeria, Spain . 3. 3 Department of Obstetrics and Gynecology, University of Granada , Granada, Spain . 4. 4 Palacios Institute of Women's Health , Madrid, Spain . 5. 5 Nutrition Department, Biosearch S.A., Granada, Spain . 6. 6 Research and Development Department, Lactalis Puleva, Granada, Spain .
Abstract
OBJECTIVE: To determine the effect of the daily intake of calcium and vitamin D-enriched milk (with or without fructooligosaccharides [FOS]) on vitamin D, bone metabolism, and cardiovascular risk factors. MATERIALS AND METHODS: Two-year randomized controlled study, including 500 healthy postmenopausal women, assigned to 500 mL/day of skimmed milk to one of three groups: Low-dose (L): (120 mg/100 mL calcium, vitamin D3 30 UI/100 mL), group A: calcium and vitamin D (180 mg/100 mL and 120 UI/100 mL), and group B: calcium and vitamin D (180 mg/100 mL and 120 UI/100 mL) and FOS (5 g/L). We evaluated serum 25(OH)D, bone mineral density (BMD) by Dual Energy X-ray Absorptiometry, and biochemical data of glucose and lipid metabolism. RESULTS: After 24 months, vitamin D concentrations did not change in the control group, but increased in group A and group B, p < 0.001. We observed an increase in femoral neck BMD and an improvement in fasting plasma glucose, HbA1c, total cholesterol, low-density lipoprotein cholesterol, and apolipoprotein B 100. CONCLUSIONS: Daily intake of milk enriched with calcium and vitamin D in postmenopausal healthy women induces a significant improvement in vitamin D status, a significant increase in BMD at femoral neck, and also favorable effects on glucose and lipid profile.
RCT Entities:
OBJECTIVE: To determine the effect of the daily intake of calcium and vitamin D-enriched milk (with or without fructooligosaccharides [FOS]) on vitamin D, bone metabolism, and cardiovascular risk factors. MATERIALS AND METHODS: Two-year randomized controlled study, including 500 healthy postmenopausal women, assigned to 500 mL/day of skimmed milk to one of three groups: Low-dose (L): (120 mg/100 mL calcium, vitamin D3 30 UI/100 mL), group A: calcium and vitamin D (180 mg/100 mL and 120 UI/100 mL), and group B: calcium and vitamin D (180 mg/100 mL and 120 UI/100 mL) and FOS (5 g/L). We evaluated serum 25(OH)D, bone mineral density (BMD) by Dual Energy X-ray Absorptiometry, and biochemical data of glucose and lipid metabolism. RESULTS: After 24 months, vitamin D concentrations did not change in the control group, but increased in group A and group B, p < 0.001. We observed an increase in femoral neck BMD and an improvement in fasting plasma glucose, HbA1c, total cholesterol, low-density lipoprotein cholesterol, and apolipoprotein B 100. CONCLUSIONS: Daily intake of milk enriched with calcium and vitamin D in postmenopausal healthy women induces a significant improvement in vitamin D status, a significant increase in BMD at femoral neck, and also favorable effects on glucose and lipid profile.
Entities:
Keywords:
calcium; nutritional intervention; postmenopausal; vitamin D
Authors: Payam Sharifan; Elahe Hassanzadeh; Maryam Mohammadi-Bajgiran; Vahid Reza Dabbagh; Elham Aminifar; Hamideh Ghazizadeh; Sara Saffar-Soflaei; Susan Darroudi; Davoud Tanbakouchi; Mohammad Reza Fazl-Mashhadi; Ali Ebrahimi-Dabagh; Mohammad Amin Mohammadi; Anahid Hemmatpur; Gordon A Ferns; Habibollah Esmaily; Ramin Sadeghi; Majid Ghayour-Mobarhan Journal: Arch Bone Jt Surg Date: 2022-07