BACKGROUND: In vivo imaging of the complex cascade of events known to be pivotal elements in the healing of cutaneous wounds is a difficult but essential task. Current techniques are highly invasive, or lack the level of vascular and structural detail required for accurate evaluation, monitoring and treatment. We aimed to use an advanced optical coherence tomography (OCT)-based angiography (OCTA) technique for the non-invasive, high resolution imaging of cutaneous wound healing. METHODS: We used a clinical prototype OCTA to image, identify and track key vascular and structural adaptations known to occur throughout the healing process. Specific vascular parameters, such as diameter and density, were measured to aid our interpretations under a spatiotemporal framework. RESULTS: We identified multiple distinct, yet overlapping stages, hemostasis, inflammation, proliferation, and remodeling, and demonstrated the detailed vascularization and anatomical attributes underlying the multifactorial processes of dermatologic wound healing. CONCLUSIONS: OCTA provides an opportunity to both qualitatively and quantitatively assess the vascular response to acute cutaneous damage and in the future, may help to ascertain wound severity and possible healing outcomes; thus, enabling more effective treatment options.
BACKGROUND: In vivo imaging of the complex cascade of events known to be pivotal elements in the healing of cutaneous wounds is a difficult but essential task. Current techniques are highly invasive, or lack the level of vascular and structural detail required for accurate evaluation, monitoring and treatment. We aimed to use an advanced optical coherence tomography (OCT)-based angiography (OCTA) technique for the non-invasive, high resolution imaging of cutaneous wound healing. METHODS: We used a clinical prototype OCTA to image, identify and track key vascular and structural adaptations known to occur throughout the healing process. Specific vascular parameters, such as diameter and density, were measured to aid our interpretations under a spatiotemporal framework. RESULTS: We identified multiple distinct, yet overlapping stages, hemostasis, inflammation, proliferation, and remodeling, and demonstrated the detailed vascularization and anatomical attributes underlying the multifactorial processes of dermatologic wound healing. CONCLUSIONS: OCTA provides an opportunity to both qualitatively and quantitatively assess the vascular response to acute cutaneous damage and in the future, may help to ascertain wound severity and possible healing outcomes; thus, enabling more effective treatment options.
Authors: Zhijia Yuan; Julia Zakhaleva; Hugang Ren; Jingxuan Liu; Weiliam Chen; Yingtian Pan Journal: Tissue Eng Part C Methods Date: 2010-04 Impact factor: 3.056
Authors: Monika Kuck; Helene Strese; Seyed Arash Alawi; Martina C Meinke; Joachim W Fluhr; Guido J Burbach; Martin Krah; Wolfram Sterry; Jürgen Lademann Journal: Skin Res Technol Date: 2013-06-19 Impact factor: 2.365
Authors: Shuxin Li; Ali H Mohamedi; Jon Senkowsky; Ashwin Nair; Liping Tang Journal: Adv Wound Care (New Rochelle) Date: 2020-03-19 Impact factor: 4.730
Authors: Naidi Sun; Anthony C Bruce; Bo Ning; Rui Cao; Yiming Wang; Fenghe Zhong; Shayn M Peirce; Song Hu Journal: Biomed Opt Express Date: 2022-04-08 Impact factor: 3.562