BACKGROUND: The monitoring of wound-healing processes is indispensable for the therapeutic effectiveness and improved care of chronic wounds. Histological sections provide the best morphological assessment of wound recovery, but cause further tissue destruction and increase the risk of infection. Therefore, it is reasonable to apply a diagnostic tool that allows a non-invasive and reliable observation of morphological changes in wound healing. METHODS: Optical coherence tomography (OCT) is an imaging technique for in vivo evaluation of skin diseases with a resolution close to histopathology. The aim of this study was to investigate whether OCT is suited to display the phases of wound healing. For this purpose, six patients with chronic wounds were objectively characterized by OCT during a period of 2 weeks. RESULTS: Comparable results between histological findings and OCT were achieved. OCT allowed the detection of partial loss of the epidermis, vasoconstriction, vasodilatation and epithelialization. CONCLUSION: Consequently, OCT could be a potential non-invasive diagnostic tool for the characterization and monitoring of cutaneous wound-healing processes over time.
BACKGROUND: The monitoring of wound-healing processes is indispensable for the therapeutic effectiveness and improved care of chronic wounds. Histological sections provide the best morphological assessment of wound recovery, but cause further tissue destruction and increase the risk of infection. Therefore, it is reasonable to apply a diagnostic tool that allows a non-invasive and reliable observation of morphological changes in wound healing. METHODS: Optical coherence tomography (OCT) is an imaging technique for in vivo evaluation of skin diseases with a resolution close to histopathology. The aim of this study was to investigate whether OCT is suited to display the phases of wound healing. For this purpose, six patients with chronic wounds were objectively characterized by OCT during a period of 2 weeks. RESULTS: Comparable results between histological findings and OCT were achieved. OCT allowed the detection of partial loss of the epidermis, vasoconstriction, vasodilatation and epithelialization. CONCLUSION: Consequently, OCT could be a potential non-invasive diagnostic tool for the characterization and monitoring of cutaneous wound-healing processes over time.
Authors: Shuxin Li; Ali H Mohamedi; Jon Senkowsky; Ashwin Nair; Liping Tang Journal: Adv Wound Care (New Rochelle) Date: 2020-03-19 Impact factor: 4.730
Authors: George D Glinos; Sebastian H Verne; Adam S Aldahan; Liang Liang; Keyvan Nouri; Sharon Elliot; Marilyn Glassberg; Delia Cabrera DeBuc; Tulay Koru-Sengul; Marjana Tomic-Canic; Irena Pastar Journal: Wound Repair Regen Date: 2018-02-06 Impact factor: 3.617
Authors: Joanne Li; Yair Pincu; Marina Marjanovic; Andrew J Bower; Eric J Chaney; Tor Jensen; Marni D Boppart; Stephen A Boppart Journal: J Biomed Opt Date: 2016-08-01 Impact factor: 3.170
Authors: Maximillian A Weigelt; Hadar A Lev-Tov; Marjana Tomic-Canic; W David Lee; Ryan Williams; David Strasfeld; Robert S Kirsner; Ira M Herman Journal: Adv Wound Care (New Rochelle) Date: 2021-07-21 Impact factor: 4.730